WATER-SOLUBLE BIS-DIOXOPIPERAZINE DERIVATIVE

Title:

WATER-SOLUBLE BIS-DIOXOPIPERAZINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1992/000971

Kind Code:

A1

Abstract:

An acid addition salt of a bis-dioxopiperazine derivative represented by general formula (I), wherein R1 represents C1 to C6 alkyl; R2 represents hydrogen or (a); R3 represents hydrogen, C1 to C6 alkyl or -(CH2)n-A, wherein A represents carboxyl, benzyloxycarbonyl, mercapto, amino, benzyloxycarbonylamino or (b), wherein X represents hydrogen, trifluoromethyl, hydroxy, acetoxy or benzyloxy, and n represents an integer of 1 to 4; and R4 represents hydrogen or alternatively R4 and R3 are combined together to represent a 5-membered cyclic group optionally containing sulfur.

Inventors:

TAKASE MUNEAKI (JP)
NARITA TOSHIHARU (JP)
KOMATSU TOSHIHIKO (JP)

Application Number:

PCT/JP1991/000894

Publication Date:

January 23, 1992

Filing Date:

July 03, 1991

Export Citation:

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Assignee:

ZENYAKU KOGYO KK (JP)

International Classes:

A61K31/495; A61K31/496; A61P35/00; C07D241/00; C07D241/08; C07D403/14; C07D417/14; (IPC1-7): C07D241/08; C07D403/14; C07D417/14

Foreign References:

JPS61152660A

1986-07-11

Other References: