Title:
WATER-SOLUBLE EPOTHILONE DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/193757
Kind Code:
A1
Abstract:
Provided are a water-soluble Epothilone derivative represented by formula (I), a preparation method therefor and an intermediate thereof, and an application thereof in preparation of drugs for inhibiting growth of tumor cells.
Inventors:
WANG HAIBO (CN)
KUANG HONGFU (CN)
ZHANG WEI (CN)
ZHENG XIAOHE (CN)
ZHU TIANMIN (CN)
YANG ZHIQING (CN)
KUANG HONGFU (CN)
ZHANG WEI (CN)
ZHENG XIAOHE (CN)
ZHU TIANMIN (CN)
YANG ZHIQING (CN)
Application Number:
PCT/CN2017/080254
Publication Date:
November 16, 2017
Filing Date:
April 12, 2017
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07D493/04; A61K31/427; A61K47/60; A61K47/64; A61P35/00; C07D277/22; C07D413/06; C07D417/06; C07D491/044; C07K5/08
Foreign References:
| CN1217662A | 1999-05-26 |
Other References:
WANG, HAIBO ET AL.: "Synthesis and Anti-tumor Effect of PEG-Epothilone B", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 47, no. 12, 8 December 2016 (2016-12-08), pages 1507 - 1512
WANG, HAIBO ET AL.: "Synthesis and Evaluation of A Water-Soluble Epothilone B Prodrug with Remarkably Decreased Toxicity", LETTERS IN ORGANIC CHEMISTRY, vol. 13, no. 9, 31 December 2016 (2016-12-31), pages 619 - 624, XP055441264
WANG, KUN: "Preparation, Analysis and PEGylation of Epothilone B", CHINA 'S EXCELLENT MASTER'S DEGREE THESIS DATABASE OF MEDICAL AND HEALTH TECHNOLOGY, vol. 13, 15 January 2013 (2013-01-15), pages 39 - 53, XP055441264
ZHANG, HAIYAN ET AL.: "Synthesis and in vitro cytotoxicity of polyethylene glycol-epothilone B conjugates", JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH, vol. 41, no. 1, 28 February 2014 (2014-02-28), pages 90 - 93
WANG, HAIBO ET AL.: "Synthesis and Evaluation of A Water-Soluble Epothilone B Prodrug with Remarkably Decreased Toxicity", LETTERS IN ORGANIC CHEMISTRY, vol. 13, no. 9, 31 December 2016 (2016-12-31), pages 619 - 624, XP055441264
WANG, KUN: "Preparation, Analysis and PEGylation of Epothilone B", CHINA 'S EXCELLENT MASTER'S DEGREE THESIS DATABASE OF MEDICAL AND HEALTH TECHNOLOGY, vol. 13, 15 January 2013 (2013-01-15), pages 39 - 53, XP055441264
ZHANG, HAIYAN ET AL.: "Synthesis and in vitro cytotoxicity of polyethylene glycol-epothilone B conjugates", JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH, vol. 41, no. 1, 28 February 2014 (2014-02-28), pages 90 - 93
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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