Title:
WATER-SOLUBLE FLUORESCENT PROBE AND NANOPARTICLES CAPABLE OF BEING USED FOR OVARIAN CANCER AND HAVING AGGREGATION INDUCED EMISSION EFFECT, AND PREPARATION METHODS AND APPLICATIONS OF WATER-SOLUBLE FLUORESCENT PROBE AND NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2020/007210
Kind Code:
A1
Abstract:
Disclosed are a water-soluble fluorescent probe and nanoparticles having an aggregation induced emission (AIE) effect and preparation methods and applications. A fluorescent probe molecular comprises the characteristics of containing two methoxyphenyl groups and one imidazole ring substituted by a phenyl group, and two quaternary ammonium salt structures, has good dispersion in water, can form micelles, has the characteristics of having the AIE effect and a large Stokes shift, and is applicable to a fluorescence detection. Under the induction of lysophosphatidic acids, the probe can be self-assembled so as to aggregate and generate yellow fluorescence, a quantitative analysis of lysophosphatidic acids can be achieved by measuring the intensity of emitted light. The probe has the advantages of excellent specificity, high sensitivity, and strong anti-interference, and is particularly applicable to the detections of lysophosphatidic acids in environments such as a chemical solution system and biological samples. The probe has a very important practical value in the detection of trace amounts of lysophosphatidic acids, a content measurement of lysophosphatidic acids in blood plasma of an ovarian cancer patient, and an early clinical diagnosis and medication guidance.
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Inventors:
ZENG WENBIN (CN)
LI SHI (CN)
LIU ZUYUAN (CN)
HUANG XUEYAN (CN)
GAO TANG (CN)
LI SHI (CN)
LIU ZUYUAN (CN)
HUANG XUEYAN (CN)
GAO TANG (CN)
Application Number:
PCT/CN2019/092455
Publication Date:
January 09, 2020
Filing Date:
June 24, 2019
Export Citation:
Assignee:
HUNAN TARGETING DETECTION TECH CO LTD (CN)
International Classes:
C07D401/14; C09K11/06; G01N21/64
Foreign References:
| CN106699734A | 2017-05-24 | |||
| CN106632305A | 2017-05-10 |
Other References:
TANG GAO ET AL.: "A self-assembled nanoprobe for long-term cancer cell nucleus-specific staining and two-photon breast cancer imaging", CHEMICAL COMMUNICATIONS, 2 February 2018 (2018-02-02), Cambridge, United Kingdom, XP055673716
TANG GAO ET AL.: "Smart Self-Assembled Organic Nanoprobe for Protein-Specific Detection:Design, Synthesis, Application, and Mechanism Studies", ANALYTICAL CHEMISTRY, vol. 18, no. 89, 22 August 2017 (2017-08-22), Washington, DC, United States, pages 10085 - 10093, XP055673712
TANG GAO ET AL.: "Smart Self-Assembled Organic Nanoprobe for Protein-Specific Detection:Design, Synthesis, Application, and Mechanism Studies", ANALYTICAL CHEMISTRY, vol. 18, no. 89, 22 August 2017 (2017-08-22), Washington, DC, United States, pages 10085 - 10093, XP055673712
Attorney, Agent or Firm:
CHANGSHA ZONEYOUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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