Title:
WNT PATHWAY INHIBITOR COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/143501
Kind Code:
A1
Abstract:
Provided are a compound possessing the structure of formula (I) and having excellent Wnt pathway inhibitory activity, or a pharmaceutically acceptable salt, an isotope derivative, or a stereoisomer thereof. Further provided are a preparation method for the compound and a use thereof in the prevention and/or treatment of a cancer, a tumor, an inflammatory disease, an autoimmune disease, or an immune-mediated disease.
Inventors:
CHEN YUFENG (CN)
WU PENG (CN)
LIU CANFENG (CN)
LI FEIFAN (CN)
SUN ZHAO (CN)
YANG HAN (CN)
LV MENG (CN)
CHENG WANLI (CN)
JIN CHAOFAN (CN)
CHEN KAIXUAN (CN)
CHEN KEKE (CN)
WANG YOUPING (CN)
ZHU XIAOLI (CN)
HE NANHAI (CN)
WU PENG (CN)
LIU CANFENG (CN)
LI FEIFAN (CN)
SUN ZHAO (CN)
YANG HAN (CN)
LV MENG (CN)
CHENG WANLI (CN)
JIN CHAOFAN (CN)
CHEN KAIXUAN (CN)
CHEN KEKE (CN)
WANG YOUPING (CN)
ZHU XIAOLI (CN)
HE NANHAI (CN)
Application Number:
PCT/CN2023/073533
Publication Date:
August 03, 2023
Filing Date:
January 28, 2023
Export Citation:
Assignee:
ADLAI NORTYE BIOPHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/505; A61P35/00; C07D475/04
Domestic Patent References:
| WO2013093508A2 | 2013-06-27 | |||
| WO2020125759A1 | 2020-06-25 |
Foreign References:
| CN112218865A | 2021-01-12 | |||
| CN104379583A | 2015-02-25 | |||
| CN106458983A | 2017-02-22 | |||
| CN109310690A | 2019-02-05 |
Other References:
LIU ZHIQING, WANG PINGYUAN, WOLD ERIC A., SONG QIAOLING, ZHAO CHENYANG, WANG CHANGYUN, ZHOU JIA: "Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 8, 22 April 2021 (2021-04-22), US , pages 4257 - 4288, XP093080990, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01799
ASHIHARA EISHI, TAKADA TETSUYA, MAEKAWA TAIRA: "Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 106, no. 6, 1 June 2015 (2015-06-01), JP , pages 665 - 671, XP093080992, ISSN: 1347-9032, DOI: 10.1111/cas.12655
ASHIHARA EISHI, TAKADA TETSUYA, MAEKAWA TAIRA: "Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 106, no. 6, 1 June 2015 (2015-06-01), JP , pages 665 - 671, XP093080992, ISSN: 1347-9032, DOI: 10.1111/cas.12655
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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