Title:
XENOGRAFT ANIMAL MODEL FOR THE INDUCTION OF PAPILLOMAS, THE PRODUCTION OF PAPILLOMAVIRUS AND THE PROPAGATION THEREOF
Document Type and Number:
WIPO Patent Application WO2000032226
Kind Code:
B1
Abstract:
The present invention relates to an animal model for inducing, producing and propagating papillomavirus and for evaluating candidate therapeutic agents against papillomavirus. The animal model comprises an immuno-deficient animal recipient onto which is grafted excised skin from a xenogeneic donor animal that is free from apparent PV infection and is a host to a host-specific papillomavirus. The grafted skin on the recipient animal supports the propagation of its host-specific papillomavirus. The invention particularly relates to, a recipient animal being a xenograft animal, capable of being a host for propagating a host specific papillomavirus and a means for producing infectious papillomavirus suspension. The invention further relates to the use of the xenograft animal model for evaluating potential therapeutic agents against papillomavirus infection.
Inventors:
DUAN JIANMIN (CA)
Application Number:
PCT/CA1999/001153
Publication Date:
January 11, 2001
Filing Date:
November 30, 1999
Export Citation:
Assignee:
BOEHRINGER INGELHEIM CA LTD (CA)
DUAN JIANMIN (CA)
DUAN JIANMIN (CA)
International Classes:
A01K67/027; A61K39/12; A61P31/12; C12N7/02; (IPC1-7): A01K67/027; A61K49/00
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