Title:
A novel helicase family member and uses thereof
Document Type and Number:
WIPO Patent Application WO2001090320
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 58224 nucleic acid molecules, which encode novel helicase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 58224 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 58224 gene has been introduced or disrupted. The invention still further provides isolated 58224 proteins, fusion proteins, antigenic peptides and anti-58224 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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Inventors:
GLUCKSMANN MARIA ALEXANDRIA (US)
Application Number:
PCT/US2001/016014
Publication Date:
April 25, 2002
Filing Date:
May 18, 2001
Export Citation:
Assignee:
MILLENIUM PHARMACEUTICALS INC (US)
International Classes:
C12N9/90; A61K38/00; (IPC1-7): C12N9/90
Other References:
JARVIS C D ET AL: "A novel putative helicase produced in early murine lymphocytes.", GENE (AMSTERDAM), vol. 169, no. 2, 1996, pages 203 - 207, XP002189623, ISSN: 0378-1119
GEIMAN T M ET AL: "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 477 - 483, XP002189624, ISSN: 0888-7543
DATABASE EMBL EBI; 12 February 2000 (2000-02-12), ISOGAI, T AND OTSUKI, T: "Homo sapiens cDNA FLJ10339 fis, clone NT2RM2000740, weakly similar to POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L", XP002189626
LEE DAVID W ET AL: "Proliferation-associated SNF2-like gene (PASG): A SNF2 family member altered in leukemia.", CANCER RESEARCH, vol. 60, no. 13, 1 July 2000 (2000-07-01), pages 3612 - 3622, XP002189625, ISSN: 0008-5472
EISEN ET AL: "Evoluton of the SNF2 family of proteins:", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 14, 1995, pages 2715 - 2723, XP002056293, ISSN: 0305-1048
GEIMAN T M ET AL: "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 477 - 483, XP002189624, ISSN: 0888-7543
DATABASE EMBL EBI; 12 February 2000 (2000-02-12), ISOGAI, T AND OTSUKI, T: "Homo sapiens cDNA FLJ10339 fis, clone NT2RM2000740, weakly similar to POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L", XP002189626
LEE DAVID W ET AL: "Proliferation-associated SNF2-like gene (PASG): A SNF2 family member altered in leukemia.", CANCER RESEARCH, vol. 60, no. 13, 1 July 2000 (2000-07-01), pages 3612 - 3622, XP002189625, ISSN: 0008-5472
EISEN ET AL: "Evoluton of the SNF2 family of proteins:", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 14, 1995, pages 2715 - 2723, XP002056293, ISSN: 0305-1048
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