Title:
pH-SENSITIVE CARRIER AND METHOD FOR PRODUCTION THEREOF, pH-SENSITIVE MEDICINE AND pH-SENSITIVE PHARMACEUTICAL COMPOSITION EACH CONTAINING SAID CARRIER, AND CULTURE METHOD USING SAID pH-SENSITIVE MEDICINE OR SAID pH-SENSITIVE PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2013/180253
Kind Code:
A1
Abstract:
Provided are: a pH-sensitive carrier which can be used as a carrier for a physiologically active substance and can respond to a weakly acidic environment to exhibit an effect of promoting a membrane-disrupting function; a method for producing the pH-sensitive carrier; a pH-sensitive medicine and a pH-sensitive pharmaceutical composition, each of which contains the carrier; and a culture method using the pH-sensitive medicine or the pH-sensitive pharmaceutical composition. A pH-sensitive carrier which can exhibit an effect of promoting a membrane-disrupting function, said pH-sensitive carrier comprising: at least one pH-sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, a higher bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof; and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan mono-fatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and α-tocopherol.
Inventors:
SAKAGUCHI NAOKI (JP)
Application Number:
PCT/JP2013/065126
Publication Date:
December 05, 2013
Filing Date:
May 24, 2013
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
A61K9/107; A61K47/28; A61K9/127; A61K38/00; A61K47/14; A61K47/22; A61K47/24; C07K17/02
Foreign References:
| JPH04360832A | 1992-12-14 | |||
| JPS63201133A | 1988-08-19 | |||
| JP2007515451A | 2007-06-14 | |||
| JPH11507031A | 1999-06-22 | |||
| JP2001515455A | 2001-09-18 | |||
| JP2006034211A | 2006-02-09 |
Other References:
SERGIO SIMOES ET AL.: "On the formation of pH- sensitive liposomes with long circulation times", ADVANCED DRUG DELIVERY REVIEWS, vol. 56, 2004, pages 947 - 965, XP008109043
OLEG A. ANDREEV ET AL.: "Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo", PNAS, vol. 104, no. 19, 8 May 2007 (2007-05-08), pages 7893 - 7898, XP009094005
S. SIMOES ET AL., ADV. DRUG DELI. REV., vol. 56, 2004, pages 947 - 965
RESHETNYAK ET AL., PNAC, vol. 104, no. 19, 2007, pages 7893 - 7898
SHOUSHICHI NOJIMA; JYUNZOU SUNAMOTO; KEIZOU INOUE: "Liposomes", NANKOUDOU
"Liposomes in Life Science", SPRINGER-VERLAG
K. KONO ET AL., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1040 - 1048
K. KONO ET AL., BIOMATERIALS, vol. 29, 2008, pages 4029 - 4036
VINCENT M. ROTELLO ET AL., J. AM. CHEM. SOC., vol. 132, no. 8, 2010, pages 2642 - 2645
OLEG A. ANDREEV ET AL.: "Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo", PNAS, vol. 104, no. 19, 8 May 2007 (2007-05-08), pages 7893 - 7898, XP009094005
S. SIMOES ET AL., ADV. DRUG DELI. REV., vol. 56, 2004, pages 947 - 965
RESHETNYAK ET AL., PNAC, vol. 104, no. 19, 2007, pages 7893 - 7898
SHOUSHICHI NOJIMA; JYUNZOU SUNAMOTO; KEIZOU INOUE: "Liposomes", NANKOUDOU
"Liposomes in Life Science", SPRINGER-VERLAG
K. KONO ET AL., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1040 - 1048
K. KONO ET AL., BIOMATERIALS, vol. 29, 2008, pages 4029 - 4036
VINCENT M. ROTELLO ET AL., J. AM. CHEM. SOC., vol. 132, no. 8, 2010, pages 2642 - 2645
Attorney, Agent or Firm:
HATTA & ASSOCIATES (JP)
Hatta international patent business corporation (JP)
Hatta international patent business corporation (JP)
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