Title:
sPLA2 IIA POLYMORPHISM ANALYSIS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT
Document Type and Number:
WIPO Patent Application WO/2011/020906
Kind Code:
A3
Abstract:
The invention relates to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising determining, in a sample obtained from said subject, the presence or absence of a variant allele of nucleotide polymorphism (SNP) of the sPLA2 type IIA nucleic acid, wherein the SNP is selected from the group consisting of rs11573156 and rs2236771, wherein the presence of the minor allele (G) of SNP rs11573156 indicates an increased risk of having or being at risk of having or developing a cardiovascular disease and/or cardiovascular event, and the presence of the minor allele (C) of SNP rs2236771 indicates a decreased risk of having or being at risk of having or developing a cardiovascular disease and/or cardiovascular event.
Inventors:
MALLAT ZIAD (FR)
SIMON TABASSOME (FR)
DANCHIN NICOLAS (FR)
SIMON TABASSOME (FR)
DANCHIN NICOLAS (FR)
Application Number:
PCT/EP2010/062144
Publication Date:
April 14, 2011
Filing Date:
August 20, 2010
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
MALLAT ZIAD (FR)
SIMON TABASSOME (FR)
DANCHIN NICOLAS (FR)
MALLAT ZIAD (FR)
SIMON TABASSOME (FR)
DANCHIN NICOLAS (FR)
International Classes:
C12Q1/68
Other References:
WOOTTON PETER T E ET AL: "Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.", HUMAN MOLECULAR GENETICS 15 JAN 2006 LNKD- PUBMED:16368710, vol. 15, no. 2, 15 January 2006 (2006-01-15), pages 355 - 361, XP002607836, ISSN: 0964-6906
DATABASE NCBI Probe [online] 27 December 2005 (2005-12-27), "Sequence-specific oligonucleotide (SSO) probe for Homo sapiens variation rs11573156", XP002607837, Database accession no. Pr001824682
FISCHER MARCUS ET AL: "Genetic variants within the PLA2G2A gene encoding secretory phospholipase A2 group IIA are related to the risk of myocardial infarction", CIRCULATION, October 2006 (2006-10-01), & 79TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; CHICAGO, IL, USA; NOVEMBER 12 -15, 2006, XP002607838, Retrieved from the Internet
WOOTTON PETER T E ET AL: "Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.", HUMAN MOLECULAR GENETICS 15 JUN 2007 LNKD- PUBMED:17545304, vol. 16, no. 12, 15 June 2007 (2007-06-15), pages 1437 - 1444, XP002607839, ISSN: 0964-6906
DIVCHEV DIMITAR ET AL: "The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?", VASCULAR HEALTH AND RISK MANAGEMENT 2008 LNKD- PUBMED:18827909, vol. 4, no. 3, 2008, pages 597 - 604, XP002607840, ISSN: 1176-6344
KOENIG WOLFGANG ET AL: "Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease", EUROPEAN HEART JOURNAL (ONLINE), OXFORD UNIVERSITY PRESS, GB, US, NL LNKD- DOI:10.1093/EURHEARTJ/EHP302, vol. 30, no. 22, 7 August 2009 (2009-08-07), pages 2742 - 2748, XP002565770, ISSN: 1522-9645, [retrieved on 20090807]
SIMON TABASSOME ET AL: "Genetic Determinants of Response to Clopidogrel and Cardiovascular Events", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US LNKD- DOI:10.1056/NEJMOA0808227, vol. 360, no. 4, 22 January 2009 (2009-01-22), pages 363 - 375, XP002603681, ISSN: 0028-4793
SIMON TABASSOME ET AL: "Impact of Secretory PLA2-IIa Gene Polymorphims on sPLA2 Activity and Cardiovascular Events Following an AMI: Results From the French Registry of Acute ST Elevation or Non-ST-elevation Myocardial Infarction (FAST-MI) Registry", CIRCULATION, November 2009 (2009-11-01), & 82ND SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; ORLANDO, FL, USA; NOVEMBER 14 -18, 2009, XP002607841, Retrieved from the Internet
EXETER H ET AL: "FUNCTIONALITY OF PLA2G2A PROMOTER VARIANTS ASSOCIATED WITH SPLA2-IIA LEVELS", ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER, vol. 11, no. 2, MS15, June 2010 (2010-06-01), pages 112, XP027097377, ISSN: 1567-5688, [retrieved on 20100601]
GUARDIOLA M ET AL: "P156 PLA2G2A, PLA2G5 AND PLA2G10 VARIANTS, SPLA2 ACTIVITY AND MASS AND CHD RISK: RESULTS FROM GRACE AND EPIC-NORFOLK", ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER, vol. 11, no. 2, June 2010 (2010-06-01), pages 49, XP027097084, ISSN: 1567-5688, [retrieved on 20100601]
DATABASE NCBI Probe [online] 27 December 2005 (2005-12-27), "Sequence-specific oligonucleotide (SSO) probe for Homo sapiens variation rs11573156", XP002607837, Database accession no. Pr001824682
FISCHER MARCUS ET AL: "Genetic variants within the PLA2G2A gene encoding secretory phospholipase A2 group IIA are related to the risk of myocardial infarction", CIRCULATION, October 2006 (2006-10-01), & 79TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; CHICAGO, IL, USA; NOVEMBER 12 -15, 2006, XP002607838, Retrieved from the Internet
WOOTTON PETER T E ET AL: "Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.", HUMAN MOLECULAR GENETICS 15 JUN 2007 LNKD- PUBMED:17545304, vol. 16, no. 12, 15 June 2007 (2007-06-15), pages 1437 - 1444, XP002607839, ISSN: 0964-6906
DIVCHEV DIMITAR ET AL: "The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?", VASCULAR HEALTH AND RISK MANAGEMENT 2008 LNKD- PUBMED:18827909, vol. 4, no. 3, 2008, pages 597 - 604, XP002607840, ISSN: 1176-6344
KOENIG WOLFGANG ET AL: "Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease", EUROPEAN HEART JOURNAL (ONLINE), OXFORD UNIVERSITY PRESS, GB, US, NL LNKD- DOI:10.1093/EURHEARTJ/EHP302, vol. 30, no. 22, 7 August 2009 (2009-08-07), pages 2742 - 2748, XP002565770, ISSN: 1522-9645, [retrieved on 20090807]
SIMON TABASSOME ET AL: "Genetic Determinants of Response to Clopidogrel and Cardiovascular Events", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US LNKD- DOI:10.1056/NEJMOA0808227, vol. 360, no. 4, 22 January 2009 (2009-01-22), pages 363 - 375, XP002603681, ISSN: 0028-4793
SIMON TABASSOME ET AL: "Impact of Secretory PLA2-IIa Gene Polymorphims on sPLA2 Activity and Cardiovascular Events Following an AMI: Results From the French Registry of Acute ST Elevation or Non-ST-elevation Myocardial Infarction (FAST-MI) Registry", CIRCULATION, November 2009 (2009-11-01), & 82ND SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; ORLANDO, FL, USA; NOVEMBER 14 -18, 2009, XP002607841, Retrieved from the Internet
EXETER H ET AL: "FUNCTIONALITY OF PLA2G2A PROMOTER VARIANTS ASSOCIATED WITH SPLA2-IIA LEVELS", ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER, vol. 11, no. 2, MS15, June 2010 (2010-06-01), pages 112, XP027097377, ISSN: 1567-5688, [retrieved on 20100601]
GUARDIOLA M ET AL: "P156 PLA2G2A, PLA2G5 AND PLA2G10 VARIANTS, SPLA2 ACTIVITY AND MASS AND CHD RISK: RESULTS FROM GRACE AND EPIC-NORFOLK", ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER, vol. 11, no. 2, June 2010 (2010-06-01), pages 49, XP027097084, ISSN: 1567-5688, [retrieved on 20100601]
Attorney, Agent or Firm:
BERNARDI, Céline et al. (52 rue de la Victoire, Paris Cedex 09, FR)
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