Title:
siRNA FOR SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR-2
Document Type and Number:
WIPO Patent Application WO/2023/176862
Kind Code:
A1
Abstract:
For example, the present invention provides a new siRNA that has a gene expression suppressing action and/or an RNA interference action with respect to mRNA encoding TfR2. The present invention pertains to: an oligonucleotide that has a knockdown action with respect to mRNA of transferrin receptor-2 and that includes an antisense strand region including a target corresponding sequence that is substantially complementary to a target sequence in mRNA encoding TfR2, and a sense strand region including a nucleotide sequence substantially complementary to the target corresponding sequence in the antisense strand region; a pharmaceutically acceptable salt of the oligonucleotide; and the like.
Inventors:
KOIZUMI MAKOTO (JP)
SHOJI TAKAO (JP)
FUKUNAGA TAICHI (JP)
SHOJI TAKAO (JP)
FUKUNAGA TAICHI (JP)
Application Number:
PCT/JP2023/009973
Publication Date:
September 21, 2023
Filing Date:
March 15, 2023
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/113; A61K31/712; A61K31/7125; A61K31/713; A61K47/26; A61K47/54; A61K48/00; A61P7/02; A61P43/00; C07H21/04
Domestic Patent References:
| WO2012177921A2 | 2012-12-27 | |||
| WO2010001909A1 | 2010-01-07 | |||
| WO2012074038A1 | 2012-06-07 | |||
| WO2021049504A1 | 2021-03-18 |
Foreign References:
| JP2021533804A | 2021-12-09 |
Other References:
AKINC AKIN; CHAN-DANIELS AMY; SEHGAL ALFICA; FOSTER DON; BETTENCOURT BRIAN R; HETTINGER JULIA; RACIE TIM; AUBIN JUSTIN; KUCHIMANCH: "Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 118, no. 21, 18 November 2011 (2011-11-18), US , pages 688, XP086627662, ISSN: 0006-4971, DOI: 10.1182/blood.V118.21.688.688
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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