tRNA, AMINOACYL-tRNA, POLYPEPTIDE SYNTHESIS REAGENT, UNNATURAL AMINO ACID INCORPORATION METHOD, POLYPEPTIDE PRODUCTION METHOD, NUCLEIC ACID DISPLAY LIBRARY PRODUCTION METHOD, NUCLEIC ACID/POLYPEPTIDE CONJUGATE, AND SCREENING METHOD

Title:

Document Type and Number:

WIPO Patent Application WO/2023/048291

Kind Code:

A1

Abstract:

The present invention provides tRNA produced by modifying the tRNA for tryptophan from Mycoplasma pneumoniae. The anticodon of the tRNA is UUA, and the tRNA pairs with the UAA codon. The present invention also provides a use for the tRNA.

Inventors:

ISHII YUKIKO (JP)
TOMINAGA JO (JP)
KIHARA SHIORI (JP)
HOHSAKA TAKAHIRO (JP)
WATANABE TAKAYOSHI (JP)

Application Number:

PCT/JP2022/035791

Publication Date:

March 30, 2023

Filing Date:

September 26, 2022

Export Citation:

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Assignee:

FUJIFILM CORP (JP)

International Classes:

C12N15/11; C07K1/02; C07K1/14; C12P21/02; C12Q1/6869; C40B40/08; C40B40/10

Domestic Patent References:

WO2007055429A1	2007-05-18
WO2021026506A2	2021-02-11
WO2018174078A1	2018-09-27
WO2007055429A1	2007-05-18
WO2004009709A1	2004-01-29

Foreign References:

JP2008193911A	2008-08-28
JP2012058092A	2012-03-22
JP2012058092A	2012-03-22
JP2021156183A	2021-10-07

Other References:

SIMONEAU PHILIPPE, LI CHENG-MING, LOECHEL STEVE, WENZE RAINER, HERRMANN RICHARD, HU PING-CHUAN: "Codon reading scheme in Mycoplasma pneumoniae revealed by the analysis of the complete set of tRNA genes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 21, no. 21, 25 October 1993 (1993-10-25), GB , pages 4967 - 4974, XP093054265, ISSN: 0305-1048, DOI: 10.1093/nar/21.21.4967
NUCLEIC ACIDS RES, vol. 21, no. 21, 25 October 1993 (1993-10-25), pages 4967 - 4974

Attorney, Agent or Firm:

TAIYO, NAKAJIMA & KATO (JP)

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