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WO/2006/001345A1 |
Disclosed are a crystal of a salt composed of L-lysine and citric acid, a crystal of a salt composed of L-lysine and citric acid whose 5 weight% aqueous solution has a pH of 3-6, a crystal of a salt composed of L-lysine and citric acid w...
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WO/2006/001378A1 |
Disclosed are a crystal of a salt composed of L-ornithine and citric acid, a crystal of a salt composed of L-ornithine and citric acid whose 5 weight% aqueous solution has a pH of 3-6, a crystal of a salt composed of L-ornithine and citr...
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WO/2005/121291A1 |
The invention relates to surfactant compositions made from esters or amides of the betaine glycine, produced by reaction of the glycine betaine with a sulphonic acid and an alcohol or a fatty-chain amine derived from vegetable oils. The ...
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WO/2005/121068A1 |
The present invention relates to a sequence for the preparation of amino acids, for example alpha amino acids, in particular methionine, by making use of an amidocarbonylation reaction in the presence of a cobalt carbonyl catalyst and se...
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WO/2005/121079A1 |
The present invention relates to a sequence for the preparation of amino acids, for example alpha amino acids, in particular methionine, by making use of an amidocarbonylation reaction and reuse of the catalyst.
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WO/2005/118525A1 |
The present invention relates to a process (Mukaiyama Aldol reaction) for thepreparation of compounds of formula (I) wherein R1 is C1-4 alkyl, C3-6 cycloalkyl-C1-4 alkyl or aryl-C1-4 alkyl; R2 is C1-4 alkyl, benzyl, substituted benzyl or...
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WO/2005/117526A2 |
The present invention relates to a process for the purification of Gabapentin with very low content of anions by suspending the Gabapentin acid addition salt in organic solvent and neutralizing with a base at a specified temperature rang...
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WO/2005/115971A1 |
Disclosed is a radioactive tyrosine derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a group selected from the group consisting of -11CH3, -11CH2CH3, -CH218F an...
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WO/2005/113481A1 |
Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising ...
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WO/2005/113471A1 |
A method of labeling one or the two oxygen atoms of the carboxy group of a carboxylated compound with an oxygen isotope which is either oxygen of mass number 17 (17O) or oxygen of mass number 18 (18O). The method is characterized in that...
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WO/2005/113482A1 |
The invention is directed to levalbuterol HC1 Form B and methods of making the same.
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WO/2005/113483A2 |
The invention is directed to processes for making levalbuterol HC1 Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HC1 to the suspension or slurry of the solid (R)-S...
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WO/2005/105730A2 |
The invention relates to a method of preparing an alcohol from a halogenoaromatic compound and an aldehyde, leading to an $g(a)-hydroxyalkylaromatic compound. According to the invention, the method of preparing an $g(a)-hydroxyalkylaroma...
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WO/2005/102988A1 |
A method of separately collecting an optically active amino acid amide and an optically active amino acid from an aqueous solution containing the optically active amino acid amide and the optically active amino acid together with at leas...
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WO/2005/103280A1 |
A process for producing either a 3-benzamido-2-hydroxycarboxylic acid represented by 3-benzamido-2-hydroxy-3-phenylpropionic acid or a salt thereof. The process is safe and suitable for industrial production, and the target compound havi...
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WO/2005/100302A1 |
The present invention relates to the solid state forms &agr , β, &dgr , &epsiv , and &zgr of (-)-(1R,1S)-2-amino-4-methylene-cyclopentanecarboxylic acid, to the processes for their preparation, to pharmaceutical compositions containing ...
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WO/2005/100300A1 |
A 5-aminolevulinic acid salt which is useful in the fields of microorganisms, fermentation, animals, medical science, plants and so on; a process for producing the same; a medicinal composition containing the same; and a plant vitalizer ...
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WO/2005/097713A1 |
A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.
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WO/2005/097733A1 |
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the as...
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WO/2005/097734A1 |
A method of isolating a purified amino acid from an aqueous solution of an alkali metal salt of the amino acid, which includes (1) a cation-exchange step in which the aqueous solution of an amino acid alkali metal salt is subjected to a ...
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WO/2005/095325A1 |
The present invention relates to a method of producing β-aminocarboxylic acids or their derivatives by conversion of compounds of formula (I) with ketene acetals in the presence of a base.
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WO/2005/095360A1 |
Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4,and a hydroxy group at position 8, with one ring being aromatic. Processes for the...
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WO/2005/092837A2 |
The present invention relates to a process for the preparation of gabapentin and, more particularly, it relates to a precipitation process of gabapentin by acidification of an aqueous solution deriving from the Hofmann rearrangement of 1...
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WO/2005/089354A2 |
A method and apparatus for applying a variable localized pressure to a selected portion of the human spine to modify human behavior or treat a human condition or ailment. A flexible and resilient pressure member is brought into engagemen...
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WO/2005/090294A2 |
The present invention is directed to a process of making &agr -aminooxyketone and &agr -hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence ...
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WO/2005/090283A1 |
A method of synthesising a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is ...
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WO/2005/087370A1 |
Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, whic...
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WO/2005/087709A1 |
The present invention relates to compounds cis (Z) and trans (E) stereoisomers of 4-t-butylgapentin of formula (11) and (12) and a process for the preparation of the said stereoisomers.
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WO/2005/087692A2 |
A method for a liquid-liquid extraction of hydrophilic organic compounds from aqueous solutions thereof is described. The method generally includes intermixing a sufficient quantity of a specified glycol ether with the aqueous liquor at ...
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WO/2005/084802A1 |
To enclose a Lewis-acid metal in a polymer and enable the resultant Lewis-acid metal catalyst to be recovered while maintaining the function of the catalyst. The polymer-enclosed Lewis-acid metal catalyst comprises a crosslinked polymer ...
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WO/2005/085178A1 |
A method of preparing L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine or a salt thereof and an immediate obtained in the preparation of the serine derivative are provided. The method includes decomposing an asymmetric aldol condensate of a...
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WO/2005/082840A1 |
[PROBLEMS] To provide a novel process for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained. [MEANS FOR SOLVING PROBLEMS] A process for the production of enantioselectiv...
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WO/2005/073163A1 |
Process for manufacture of 2-(2,6-dichlooranilino)phenyl acetoxy acetic acid is provided. The process comprises of acid hydrolysis 2-tert-butoxy-2-oxoethyl &lcub 2[(2,6-dichlorophenyl) amino]phenyl)acetate in presence of a strong acid ca...
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WO/2005/073196A1 |
A compound of the following formula (I). This compound (I) can be produced by reacting a 1,1'-binaphthyl 2,2'-dimethylenebromide derivative which can be produced through a relatively small number of steps with an easily available seconda...
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WO/2005/070869A1 |
The present invention describes an improved catalyst and process for the selective hydrogenation of nitro aromatics, nitrosoaromatics and aromatic hydroxyl amines to their corresponding amines using gaseous hydrogen, in the presence of s...
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WO2005026106B1 |
The present invention is directed to compositions of specific carboxylic acid, fatty acid or oil derivatives containing nitrile groups and methods of their preparation. The preparation involves a hydrocyanation reaction. A method of hydr...
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WO/2005/063682A1 |
The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical...
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WO/2005/058776A1 |
The present invention relates to a process for the resolution of derivatives of &agr -amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with ...
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WO/2005/058799A1 |
A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature.
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WO/2005/058797A1 |
A process for the preparation of gabapentin comprising the passage of a salt of the same through a ionic exchange resin of strong cationic type, the elution of the gabapentin which has fixed onto the column and the crystallization from o...
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WO/2005/037737A1 |
Disclosed is a method for producing [18F] fluoride-marked aromatic L-amino acids, according to which the marking reaction takes place on an L-enantiomeric aromatic amino acid that is provided with protective groups. Also disclosed is a m...
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WO/2005/033128A1 |
The invention relates to a method for the synthesis of the derivative having formula (I) and to the use thereof for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof.
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WO/2005/033127A1 |
The invention relates to a method for the synthesis of the derivative having formula (I) and to the use thereof for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof.
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WO/2005/030700A2 |
Certain ß-amino acids that bind to the alpha-2-delta (a2S) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other d...
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WO/2005/030701A2 |
Betaine ester quaternary ammonium compounds with reduced toxicity and improved biodegradability are formed by esterification of a haloacetic acid with an alcohol containing at least 4 carbon atoms, followed by quaternization of the haloa...
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WO/2005/028419A2 |
The present invention relates to a process for producing amino acid derivatives such as optically active β-amino acid in short steps with good yield and high optical purity, which comprises reacting a keto acid of the formula (1): where...
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WO/2005/023755A1 |
The invention relates to a method for synthesizing derivatives of formula (I), in which R represents a linear or branched alkyl group (C1-C6). The invention is used for synthesizing perindopril and pharmaceutically acceptable salts thereof.
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WO/2005/023756A1 |
The present invention relates to a new and efficient process for the manufacture of L-Threonine-O-(1,1-dimethylethyl) ester; [H-Thr-(tBu)-O-tBu] of Formula (I). The compound of Formula (I) is a key product for the manufacture of human in...
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WO/2005/021485A2 |
The invention relates to the field of pharmaceutics and more specifically to novel compositions useful in the preparation of cycloalkyaminoacids and oxazolidiones, and processes for making cycloalkylaminoacids optionally partially or ful...
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WO/2005/020930A2 |
The present invention relates to an improved synthesis of alitame (3-L-alpha-aspartyl-D-alanylamido-2,2,4,4-tetramethylthietan
ylamine) in which residual iodine species formed during the deodorization step are eliminated, resulting in an...
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