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WO/2005/019158A1 |
The invention relates to the field of pharmaceutics and more specifically to novel cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids. Formula...
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WO/2005/016866A2 |
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention...
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WO/2005/009928A2 |
The present disclosure provides methods of synthesizing alkylating agents and methods of use.
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WO/2005/007617A1 |
The invention relates to a method for reducing the formaldehyde and/or cyanide contents in technically produced solutions of sarcosine salts. According to said method, the starting solution is subjected to a thermal treatment such that: ...
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WO/2005/005371A1 |
[PROBLEMS] To provide a process for efficient production of optically active β-hydroxy-&agr -aminocarboxylic acid derivatives of anti conformation useful as intermediates of drugs or agricultural chemicals. [MEANS FOR SOLVING PROBLEMS] ...
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WO/2005/000839A1 |
An excellent process for efficiently producing a benzofuran derivative or pyridofuran derivative or a pharmacologically acceptable salt of either, the derivatives being represented by the general formula [I]: [I] (wherein X represents -N...
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WO/2004/113269A1 |
A process for the preparation of gabapentin which comprises the passage of a gabapentin inorganic salt through a strong cationic ionic exchange resin, the elution of gabapentin fixed on the column, the concentration of the resultant solu...
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WO/2004/110342A2 |
The present invention relates to Gabapentin, a useful agent for anti-convulsing. New form of Gabapentin Form-IV, a process for its preparation, and its conversion to Form-II by slurrying it in ethanol at a specified temperature.
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WO/2004/101489A1 |
The present invention relates to the process for the preparation of anhydrous Gabapentin of pharmaceutical grade from the Gabapentin acid addition salts. The process consists of neutralizing the said acid addition salts with an organic b...
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WO/2004/099120A1 |
The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids $g(a) or the derivatives thereof, having general formula (B), wherein: linkage C-O of the 4-position carbon (represe...
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WO/2004/096753A1 |
A compound usable as an asymmetric-synthesis catalyst which can be easily synthesized without using any metal such as a lanthanide group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the a...
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WO/2004/093780A2 |
The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II via a novel intermediate Gabapentin hemisulphate hemihydrate with out forming Gabapentin Form-III by neutralizing the Gabapentin...
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WO/2004/093779A2 |
The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II by converting the Gabapentin hydrochloride salt directly into Form-II without the formation of Form-III by neutralizing the Gaba...
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WO/2004/092119A2 |
The invention relates to an improved method for the production, purification and crystallisation of $g(a)-methylated cysteine or serine derivatives by an acid hydrolysis of corresponding thiazolidine or oxazolidine esters, with the conti...
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WO/2004/085378A1 |
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an ena...
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WO/2004/083163A1 |
3-Amino-3-arylpropionic acid n-alkyl esters represented by the general formula (I); a process for the production of the same; and optical isomers thereof: (I) [wherein Ar1 is optionally substituted aryl exclusive of phenyl and 4-methoxyp...
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WO/2004/075889A1 |
A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), wherein X is chlorine or bromine with compound of ...
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WO/2004/063143A1 |
A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the above formula (I), where Y is as described in the attached descri...
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WO/2004/061114A1 |
In the adsorption step of a process for producing an amino acid or its salt, an amino acid-containing aqueous solution is fed into a pressure tight column and then free amino acid is adsorbed by a carbonate type anion exchange column pac...
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WO/2004/056742A1 |
The present invention relates to an improved process for the preparation of taxol side chain by synthesizing (2R,3S)-2,3-dihydroxy-3-phenylpropionate with greater than 99% enantioselectivity and devoid of osmium even in crude form in a s...
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WO/2004/052939A2 |
One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-ca...
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WO/2004/052836A1 |
The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in c...
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WO/2004/046085A1 |
This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-ami...
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WO/2004/046084A1 |
A process for producing Gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from Gabapentin hydrochloride salt. In the process the Gabapentin hydrochloride is converted to Gabapentin using inorganic base such as Barium hydroxide. Gaba...
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WO/2004/039314A2 |
A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L- -methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclizatio...
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WO/2004/033414A1 |
Peptidomimetic compounds derived from aralkyl substitued 8-amino-3,7- or 3,6-dihydroxy alkenoic or alkanoic acids and compositions including those compounds, as well as methods of using and making the compounds are herein described. The ...
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WO/2004/031126A2 |
A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising: a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexanediacetic acid to yield 3,3-pentame...
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WO/2004/026247A2 |
Diketo- and pyridine-containing chiral crown ligands having at least two chiral bulky groups attached to two different chiral carbon atoms of the crown that are covalently bonded to or coated on suitable solid supports, and further coate...
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WO/2004/024934A1 |
A process which comprises asymmetrically hydrolyzing an N-acylated DL-erythro 3-substituted serine represented by the following general formula (1): (1) (wherein R1 represents C1-10 alkanoyl, benzoyl, C1-5 alkanoyl substituted by halogen...
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WO/2004/020392A1 |
Conversion of a boroxazolidone, a 5-membered cyclic compound derived from an &agr -amino acid, into an &agr -amino acid by an entirely new ring-opening reaction (Umezawa reaction). (I) → (II) (In the formulae, R and R' each means optio...
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WO/2004/016579A1 |
The invention relates to a method for producing 3-amino-4,4,4-trifluorocrotonic acid esters of formula (I) or their E/Z isomers or tautomeric forms, whereby R1 and R2, independent of one another, represent hydrogen, an optionally substit...
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WO/2004/016583A1 |
The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropatho...
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WO/2004/014357A2 |
The compounds of formula (I) are useful in the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain, neuropathological disorders and sleep disorders. Pr...
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WO/2004/014550A2 |
The invention relates to novel monocarbene complexes of nickel, palladium or platinum containing electron-deficient olefin ligands, to their production and to the use thereof in the homogeneous catalysis of organic reactions (Formula II ...
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WO/2004/002938A1 |
The invention relates to a separation process of fractionating a solution comprising betaine and sucrose by subjecting said solution to chromatographic fractionation and nanofiltration and recovering a fraction enriched in betaine and op...
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WO/2004/002939A2 |
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrog...
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WO/2004/003331A2 |
A chloride free amphoteric surfactant obtained by reacting an amine with a carbonyl compound, the amphoteric surfactant being particularly useful as a foamer for treating gas wells to enhance production.
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WO/2004/000784A1 |
The present invention involves a process for preparing protected amino acids. The process produces a di-tert-butyl amino ester or an N-protected di-tert-butyl amino ester by transesterification of an acidic amino acid or an N-protected a...
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WO/2004/000779A1 |
A process for producing a phenyloxocarboxylic ester derivative which comprises reacting an aromatic hydrocarbon with a carboxylic acid anhydride derivative in the presence of an acid catalyst and an alkylating agent. By the process, the ...
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WO2001002075A9 |
A method to prepare new polymorphs of materials which have not been observed or to obtain a known polymorph under different conditions than those in which it is usually made by using a laser to cause nucleation and crystal growth to occu...
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WO/2003/099269A1 |
The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewe...
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WO/2003/099758A1 |
A process of the preparation of a N,N-diamino amino acid-ß-hydroxy-succinic acid as a N,N-diacid salt (I) is described. The process involves reacting epoxy succinic acid with an amino acid having two amino groups as an N-acid salt. The ...
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WO/2003/097582A2 |
Benzonitrites and benzimidates represent important intermediates and starting materials, which are typically not commercially available. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and die...
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WO/2003/097578A1 |
The invention relates to a method for producing 2-(4-N,N-dialkylamino-2-hydroxybenzoyl)benzoates of formula (I), in which the substituents R1 to R3, independently of one another, are defined as cited in the description. Said substances a...
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WO/2003/097622A2 |
The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to des...
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WO/2003/095417A1 |
The present invention concerns a process for preparing 4-fluoro-anthranilic acid by nitration, reduction and hydrolysis of an alkyl 3-chloro-4-fluorobenzoate.
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WO/2003/093220A1 |
The invention relates to a process for preparing highly functionalized &gammad - butyrolactams and &gammad -amino acids by reductive amination of mucohalic acid or its derivatives, and discloses a process for preparing pregabalin or 3-am...
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WO/2003/093215A1 |
Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poiso...
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WO/2003/089403A1 |
The present invention provides compositions and methods of preparing gabapentin that includes (a) subjecting cyclohexanediacetic acid monoamide to a Hofmann rearrangement to yield a solution comprising an isocyanate intermediate; (b) hyd...
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WO/2003/089402A1 |
A process for producing an &agr -fluoro-β-alanine compound represented by the following formula (A) or a salt thereof, which comprises reacting an &agr -fluoroacrylic acid compound with ammonia and/or an amine at about 50 to 150&ring C ...
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