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WO/2016/071303A1 |
The invention relates to a process for the preparation of Levomilnacipran, a compound useful in the treatment of depression, comprising the following steps: a) directly converting the enantiomerically enriched form of alcohol (D) into th...
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WO/2016/071552A2 |
The present invention relates to a group of compounds with autophosphorylation-inhibiting activity and antibacterial activity against different bacteria, such as Staphylococcus aureusy Staphylococcus epidermidis , inter alia, and to the ...
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WO/2016/070712A1 |
Disclosed are amino acid derivatives and applications thereof. The amino acid derivatives contain the oxalyl group, and thus can interfere with energy metabolism of cells and induce apoptosis. Therefore, the amino acid derivatives can be...
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WO/2016/066574A1 |
Disclosed are compounds of formula (I) which possess anthelminthic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or preven...
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WO/2016/066923A1 |
The invention relates to the use of a compound of formula (I'): R'-O-CH2-CH(OH)-[CH2-O-CH2]s-[CH(OH)]p-CH2-O-R" (Ι'), formula (I´), wherein s is equal to 0 or 1, and p is equal to 0, 1, 2 or 3, R' and R", identical or different, repres...
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WO/2016/063990A1 |
The present invention relates to a compound represented by general formula (1). (The definition of each group in the formula is as described in the specification.) The compound is useful as a prophylactic and/or therapeutic agent for KCN...
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WO/2016/062212A1 |
The present invention provides a method for recycling 3-carbamoymethyl-5-methylhexanoic acid from a 3-carbamoymethyl-5-methylhexanoic acid chiral resolution mother liquor. The method comprises the following steps: (a) distilling the 3-ca...
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WO/2016/063301A2 |
The present invention discloses anti-malarial compound of formula (I) Formula (I) wherein, X is selected from O or NH; R1, R2, R3, R4 and R5 is selected from H or OMe or CH3, -CH2-O-CH2- or -CH=CH-CH=CH-; Y is selected from O or NH and R...
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WO/2016/059650A1 |
The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invent...
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WO/2016/061393A1 |
Monomethyl and monoethyl fumarate prodrugs, pharmaceutical compositions comprising the monomethyl and monoethyl fumarate prodrugs, and methods of using monomethyl and monoethyl fumarate prodrugs and pharmaceutical compositions for treati...
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WO/2016/060194A1 |
The present invention pertains to a compound represented by formula (1) (in the formula, the symbols are as described in the specification) or a salt thereof; the present invention makes it possible to provide a compound having exception...
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WO/2016/056533A1 |
The present invention provides a method for producing an aqueous solution including bis(Nε-lauroyllysine)dicarboxylic acid diamide and/or a salt thereof and having a pH of 9-11, the method including a first step for forming bis(Nε-laur...
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WO/2016/057322A1 |
Provided herein are deuterated compounds and compositions useful in increasing PPAR5 activity. The compounds and compositions provided herein are useful for the treatment of PPAR5 related diseases (e.g., muscular diseases, vascular disea...
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WO/2016/057931A1 |
The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alk...
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WO/2016/051024A1 |
The present invention relates to pounds of general formula (I) and pharmaceutically acceptable salts thereof; wherein R1 - R11, L, Z, Y, and Z are as defined in the claims. The invention also relates to said compounds for use as a medica...
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WO/2016/052283A1 |
The present invention provides: an organic semiconductor composition that makes it possible to minimize decreases in mobility and produce an organic thin film transistor having excellent insulating reliability; and an organic thin film t...
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WO/2016/051013A1 |
The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating s...
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WO/2016/053212A1 |
The present invention relates to a process for the preparation of gelling free, flowable and pumpable aqueous betaine solution with a betaine content of < %32 having the general formula (I), in which R is a mixture of C8-C18 alkyl and C8...
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WO/2016/049663A1 |
Novel crystalline Forms of trisodium [3-((1S,3R)-l-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate)
biphenyl-4'-ylmethyl}amino)butyrate] hydrate, methods for their prepa...
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WO/2016/044331A1 |
Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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WO/2016/037552A1 |
Disclosed are a crystalline ARB-NEPi compound and a preparation method therefor and an application thereof. The ARB-NEPi compound refers to [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethyloxycarbonyl-1-butylcarbamoy
l)propionic acid-(S)-3'-met...
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WO/2016/039393A1 |
The purpose of the present invention is to provide a method for high-yield, inexpensive, and safe industrial production of a lacosamide having high optical purity. The present invention addresses said issue by providing a method for high...
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WO/2016/037098A1 |
This invention relates to deuterium substituted analogs of sacubitril and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in me...
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WO/2016/034671A1 |
A compound of formula (la), (lb) or (lc) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2O...
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WO/2016/034327A1 |
Novel 2,2'-diamino biaryls of formula (I), (II) and (III), wherein R1-R10, R1'-R10', X1 - X3 and X1-X3' are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/035328A1 |
Provided are: a dispersant which has excellent solubility in a solvent, excellent adhering power to a colorant and excellent colorant dispersibility, while being reduced in self-coloring; a compound and a polymerizable compound for prepa...
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WO/2016/034330A1 |
Novel 2,2'-diamino biaryls of formula (I), (II) and (III), wherein R1-R10, R1'-R10' and X1-X3 are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/034126A1 |
A compound of formula (I) is disclosed, which has a low toxicity, can significantly inhibit the migration and invasion of tumor cells in vitro, and can inhibit tumor metastasis in vivo in mice at low concentration, while showing notable ...
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WO/2016/034328A1 |
The invention relates to novel 2,2'-diamino biaryls of formula (I), (IIa), (IIb) and (III), wherein R1-R10, R1'-R10' and X1-X3 are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/034882A1 |
The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, ...
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WO/2016/037072A2 |
Described herein are enopeptin analogs of Formula (I) or (II): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, R5, R6, m, X, RXa, and Y are as defined herein. Such compounds...
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WO/2016/032911A1 |
The present invention is directed to a process of making alkanolamides wherein the "aging" time is reduced and the diethanol amide to ester ratio in the finished product is increased. Further provided is an additive composition comprisin...
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WO/2016/029828A1 |
Disclosed are a crystalline form of an NEP inhibitor AHU-377, comprising a crystalline free acid, a hemicalcium salt and α-phenylethylamine salt, as well as a preparation method therefor and an application thereof. The physicochemical p...
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WO/2016/032182A1 |
Disclosed is a novel adamantane derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. In addition, disclosed is a method for preparing the novel ad...
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WO/2016/029136A1 |
Disclosed are novel benzamide compounds and the uses thereof for treating diseases and disorders in a patient in need thereof by increasing cellular levels of A3G and/or other members of the A3 family of proteins in the patient. The disc...
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WO/2016/027282A1 |
The present invention provides a compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. [Formula should be entered here] General formula A where in B ...
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WO/2016/025681A1 |
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region...
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WO/2016/020350A1 |
The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti...
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WO/2016/018553A1 |
Cure accelerators for anaerobic curable compositions, such as adhesives and sealants, are provided, and which are defined with reference to the aromatic amides shown in structure I where R and R" are each independently C1-10 alkyl, and R...
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WO/2016/017713A1 |
Provided is an oil and water separation device that can easily and inexpensively separate and collect the oil component from a mixed fluid comprising water and oil. This oil and water separation device gravity-filters a mixed fluid compr...
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WO/2016/017754A1 |
This filter medium for separating a liquid containing water and oil and having a channel for the liquid also has a substrate constituting the channel, and one or more types of nitrogen-containing fluorine-based compounds present on the s...
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WO/2016/017768A1 |
This hydrophilic oil-repellent complex includes one or more types of nitrogen-containing fluorine compounds, and an inorganic compound that has an electric charge or ionic group. The nitrogen-containing fluorine compound includes, within...
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WO/2016/016276A1 |
Provided herein are methods of improving the dissolution rate in water of a compound of Formula (F) in the form of any one of its stereoisomers or a mixture thereof, and wherein n is an integer from 0 to 2; the dotted line represents a c...
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WO/2016/017686A1 |
This hydrophilic oil repellent agent includes at least one species of nitrogen-containing fluorine compound. The nitrogen-containing fluorine compound includes, in the molecule thereof, any one hydrophilicity-imparting group selected fro...
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WO/2016/017659A1 |
The purpose of the present invention is to provide a medium-chain acyl basic amino acid derivative that, when combined with a liquid cosmetic such as a toilet water or a milky lotion, can preserve a sensation of skin compatibility, etc.,...
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WO/2016/016162A1 |
The present invention relates to a compound of formula (I), wherein L is –C(O)NH-, -NHC(O)-, -S(O)2NH-, -NH- or -NHC(O)NH-; Ar is phenyl, benzyl, naphthyl or heteroaryl, selected from the group consisting of pyridinyl, pyrazolyl, pyrim...
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WO/2016/013033A1 |
The present invention discloses a novel vinylic 3-amino-1,2 diol compounds of formula (I) and a one pot cost-effective process for the synthesis of vinylic-3-amino-1,2-diols of formula (I) which comprises tandem α-amination-benzoyloxyal...
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WO/2016/011535A1 |
Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations compr...
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WO/2016/005407A1 |
The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time c...
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WO/2016/004166A1 |
Boron-based prodrugs of phenol- or aromatic hydroxyl group -containing therapeutic molecules ("original drugs"), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged r...
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