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WO/2012/137152A2 |
The present invention relates to a method for preparing formamide compounds using carbon dioxide, and to the use of said method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticide...
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WO/2012/138706A1 |
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of ma...
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WO/2012/138920A1 |
The disclosure provides a capture system and methods for isolating cysteine-containing peptides from biological fluid and proteolytic mixtures. The disclosure also provides compounds of formulae (II), (III), and (IV), useful in methods o...
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WO/2012/133871A1 |
A polymerizable monomer is provided which is represented by the following formula (1): wherein R1 represents a hydrogen atom or an alkyl group; A represents -CO- or -SO2-; and the moiety represented by the formula (1) is, at the part sho...
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WO/2012/133182A1 |
The objective of the present invention is to provide a polyether compound which is useful as a curing agent and the like, a curing agent which uses the compound, and a method for producing the compound. A polyether compound of the presen...
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WO/2012/126386A1 |
The present invention provides a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof and a pharmaceutical composition containing the same, wherein the mixed crystal mainly contains an agomelatine crystal form VI...
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WO/2012/126385A1 |
The present invention provides a new crystal form VII of agomelatine, the preparation method and use thereof and a pharmaceutical composition containing the same. The new crystal form has a good purity, a stable crystal form and good rep...
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WO/2012/125305A1 |
The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide recep...
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WO/2012/123328A1 |
The invention relates to a novel process for preparing aromatic primary amides. The process involves reacting a compound of formula (II) with liquid ammonia in the presence of a solid Lewis acid catalyst to form a compound of formula (I)...
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WO/2012/121301A1 |
[Problem] To provide a process for producing a fluorine-containing substituted compound, which can produce the fluorine-containing substituted compound under temperature conditions that can be achieved industrially, using a simple appara...
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WO/2012/121248A1 |
A method for highly enantio-selectively producing an optically active spirolactone compound using a iodoarene derivative which can be easily synthesized and scarcely racemized. From 2,6-dihydroxyiodoarene, a flexibly designable hypervale...
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WO/2012/116493A1 |
A chiral hydrogenation H8-BINOL bisphosphine compound is provided, with structural formula (I), wherein R1 and R2 are from halogen, H or C1-C10 fatty group; R3 is H or C1-C10 fatty group; R4 is from halogen, amino, nitro, H, C1-C10 fatty...
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WO/2012/117097A1 |
The invention relates to selective, non-steroidal 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2) inhibitors of formula (I), their production and use, notably for the treatment and prophylaxis of sex steroid deficient diseases l...
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WO/2012/113999A1 |
A process for the industrial synthesis of the compound of formula (I) from the allyl cyanide of formula (II) and a compound of formula (III), wherein Xa is an -S-C(S)-OR group in which R is a linear or branched (C1-C6) alkyl group.
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WO/2012/113891A1 |
The present invention relates to the use of polyaminoisoprenylderivatives in antibiotic or antiseptic treatment of bacteria including those presentingmultiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relate...
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WO/2012/112742A1 |
In one aspect, the invention relates to compounds having the formula: (I) where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity...
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WO/2012/111741A1 |
Provided are: uses of a polymer that includes structural units derived from compounds represented by formula (a), as a surfactant having a superior ability to reduce surface tension or as a surface modifier and coating material for impar...
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WO/2012/108478A1 |
The present invention is a compound represented by formula (I) (in the formula, each of the reference numerals is as recited in the specification) or a salt thereof.
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WO/2012/104793A1 |
The invention provides a compound represented by Formula (I) 5-(4-bromobutyl)-N-(but-3-enyl)dodec-11-enamide or a derivative thereof. Said compound is effective against bacterial and viral pathogens.
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WO/2012/103583A1 |
The present invention relates to compounds of formula (I) with the substituents as described within the specification. The compounds are useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR). The in...
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WO/2012/100865A1 |
The present invention relates to agrochemical compositions comprising certain benzamide compounds and to the use of those benzamide compounds as adjuvants, especially in formulations,in particular in agrochemical formulations and in envi...
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WO/2012/102239A1 |
The present invention provides a process for producing an aromatic amidecarboxylic acid derivative represented by general formula (2), comprising a step of reacting an aromatic amidehalide derivative represented by general formula (1) wi...
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WO/2012/097764A1 |
The invention provides a method for the preparation of chemically and polymorphously stable composition of agomelatine, based on a metastable form of agomelatine represented by the chemical formula (1), as well as a reproducible method o...
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WO/2012/096635A1 |
We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity ...
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WO/2012/093411A2 |
The invention provides a process for resolution of R (±) - 3- (carbamoylmethyl)-5-methylhexanoic acid I to form enantiomerically pure form of compound of formula (I), the said process comprises resolution of racemic mixture of compound ...
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WO/2012/093225A1 |
Process for the industrial synthesis of the compound of formula (I).
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WO/2012/088648A1 |
Disclosed are the deuterated acid salts of oseltamivir, namely, ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohex
ene-1-carboxylate, hydrates thereof and their preparation methods. More specifically, oseltamivir phosphat...
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WO/2012/085586A1 |
The present invention concerns prodrugs of mexiletine (and mexiletine's active metabolite) pharmaceutical compositions containing such prodrugs. Methods for treating myotonic conditions, while reducing the inherent adverse G1 side effect...
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WO/2012/077221A1 |
Provided are: a 3-aminooxalylaminobenzamide derivative for use in an insecticidal and acaricidal agent; and an intermediate thereof. The 3-aminooxalylaminobenzamide derivative is represented by formula [1] [wherein R1 and R2 are each C1-...
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WO/2012/076466A2 |
The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for prod...
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WO/2012/076831A1 |
The present invention pertains generally to the field of coolants and medical therapy. More particularly, the present invention relates to certain anti-nociceptive agents, such as [((1R,2S,5f?)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-a...
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WO/2012/073910A1 |
Provided are a method for producing a sanshool, the method having a short process and being highly stereoselective, and an iron carbonyl complex compound which is a useful intermediate for the method of production. A diene iron complex c...
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WO/2012/070025A1 |
The present invention relates to a process for the manufacture of N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide (Agomelatine) with improved yield and reduced level of N- acetyl-N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide impurity.
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WO/2012/071371A2 |
The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled glycans and glycosphingolipids in microa...
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WO/2012/069605A1 |
The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing infla...
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WO/2012/071102A2 |
A method of buffering a chemical or biological composition, comprising adding to the composition an effective buffering amount of at least one protonated or un-protonated amine-quaternary ammonium compound having a general formula(CI)d w...
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WO/2012/065891A1 |
The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in sub...
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WO/2012/065932A1 |
The present invention relates to decahydro-1,4-methanonaphthalen carboxamide derivatives of formula (Ia) or (Ib); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for t...
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WO/2012/062799A1 |
The invention relates to a compound of the following formula (I): to its method for making it and to its uses for preparing a polymer useful for increasing the heat resistance of polymeric compositions.
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WO/2012/065110A2 |
S-protected cysteine analogs and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).
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WO/2012/060396A1 |
The purpose of the present invention is to provide a novel trans-2-decenoic acid derivative and a pharmaceutically acceptable salt thereof, and a medicament containing the compound described above as an active component and having a neur...
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WO/2012/059443A2 |
The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substitu...
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WO/2012/058866A1 |
Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula ...
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WO/2012/052550A1 |
Disclosed are novel cross-linkable end-cappers for oligo-and polyamides. End-capped oligo-and polyamides comprising such an end-capper may be cured at a lower temperature compared to oligo-and polyamides end-capped with PEPA.
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WO/2012/052163A1 |
Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at leas...
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WO/2012/052829A1 |
The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides novel intermediates used in the preparation ...
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WO/2012/052160A1 |
Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the ...
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WO/2012/052161A1 |
Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic g...
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WO/2012/049338A1 |
The present invention describes vinyl sulfone-derived compounds that comprise a core of PAMAM derivatized with alkyl sulfonyl groups, and the method for production thereof. These compounds form complexes with DNA fragments that are usefu...
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WO/2012/048845A1 |
Disclosed are halogenated diethyltoluenediamines of formula I, wherein either R1 is an amino group and R2 is chlorine or bromine, or R2 is an amino group and R1 is chlorine or bromine, and isomeric mixtures thereof. The halogenated dieth...
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