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JPH09500637A |
The present invention relates to novel 1 alpha -hydroxy vitamin D derivatives in which the 17-position side chain carries an azide or optionally substituted 1,2,3-triazole group, including compounds of general formula (I) where R1 repres...
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JP2571250B2 |
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JP2571230B2 |
A novel process and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula in which R<1> represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl(lower alkyl), aryl, aryl(lower alky...
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JPH0912538A |
To easily obtain a new 9(Z)-retinoic acid derivative important for cancer therapy while minimizing the toxic side effect of free 9(Z)-vitamin A acid. This new compound is expressed by the formula [Y is OCR12- CO-R2 (R1 is H, a 1-20C alky...
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JPH08325226A |
PURPOSE: To obtain a vitamin D3 derivative by a coupling reaction using a palladium catalyst, useful as a medicine. CONSTITUTION: The 1α,24-dihydroxy-22(E)-dehydrovitamin D3 of formula I [R is H, a tri(alkyl)silyl, etc.; R2 and R3 are e...
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JP2557514B2 |
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JPH08301842A |
PURPOSE: To obtain a new fluorinated vitamin D derivative having in vivo Ca controlling action or differentiating-inducing action of tumor cell and useful as a treating medicine for rickets having renal insufficiency, osteoporosis, etc.,...
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JP2550391B2 |
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JP2547581B2 |
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JP2547595B2 |
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JP2543396B2 |
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JP2542667B2 |
Process for the preparation of compounds of the formula in which R<1> denotes hydroxyl or an etherified hydroxyl group, and of zeaxanthine, characterised in that a compound of the formula in which R<1> has the above meaning, is converted...
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JP2536026B2 |
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JPH08239360A |
PURPOSE: To efficiently obtain a new compound, capable of separating various actions of vitamin D and useful as a strong medicine having the persistence by using a well-known starting raw material in a short process. CONSTITUTION: This c...
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JPH08225480A |
PURPOSE: To obtain an ene-yne compound useful as a synthetic intermediate of an active form of a vitamin D3 derivative in an effective manner by reacting an optically active alcohol derivative with an ethylene metal salt and subsequently...
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JP2522954B2 |
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JP2520154B2 |
A process for producing carotenoids and carotenoid intermediates via reduction of sulfonyl polyenes with a dithionite in the presence of ammonia or an aliphatic amine, including novel intermediates in this process, which carotenoids are ...
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JP2505669B2 |
PURPOSE: To obtain a novel compd. useful in a method which does not require photochemical conversion and does not require an isomerization process for vitamin derivatives at the time of a stereoregular synthesis of 24,25- dihydroxycholec...
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JP2505713B2 |
PURPOSE: To provide a novel vitamin D-22-phenylsulfone deriv. which is a compd. useful for induction of differentiation of malignant cells and treatment of tumor diseases and can be used for the synthesis of vitamin D metabolite and the ...
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JP2502931B2 |
PURPOSE: To obtain a new compound useful in the treatment of hyperproliferative skin diseases such as psoriasis and sebaceous gland diseases such as seborrheic eczema. CONSTITUTION: The compound of formula I (R1 and R2 are each H or an a...
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JPH08504746A |
PCT No. PCT/DK93/00196 Sec. 371 Date Sep. 1, 1994 Sec. 102(e) Date Sep. 1, 1994 PCT Filed Jun. 7, 1993 PCT Pub. No. WO94/01398 PCT Pub. Date Jan. 20, 1994The invention relates to vitamin D compounds of formula (I) (I) in which X is hydro...
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JPH08113559A |
PURPOSE: To obtain a vitamin d3 derivative containing a carbonyl group at a part corresponding to 24-position of 22-oxavitamin D3 useful as a medicine, having strongly differentiation-inducing action. CONSTITUTION: This compound is shown...
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JPH08109191A |
To obtain the subject new intermediate used for synthesizing the vitamin D3 analogs, having actions for stimulating the differentiation of human keratinocytes and lowering their proliferation, and useful for treating hyperproliferative s...
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JPH08503700A |
PCT No. PCT/DK93/00351 Sec. 371 Date May 2, 1995 Sec. 102(e) Date May 2, 1995 PCT Filed Nov. 1, 1993 PCT Pub. No. WO94/10139 PCT Pub. Date May 11, 1994The invention relates to 20(S)-vitamin D compounds having the following formula where ...
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JPH0873425A |
PURPOSE: To provide a new fluorinated vitamin D derivative free from side action when used as a remedy for osteoporosis and expected to have an improved bone-quantity improving action compared with conventional active vitamin D derivativ...
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JPH0825993B2 |
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JPH08501531A |
The invention relates to vitamin D derivatives, modified in 20-position, of general formula I I in which X, Y, Z, R1, R2 as well as R3 have the meaning indicated in the description, process for their production and their use as agents fo...
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JPH08501571A |
PCT No. PCT/DK95/00305 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Sep. 23, 1993 PCT Pub. No. WO94/07851 PCT Pub. Date Apr. 14, 1994A compound of formula I I wherein R stands for a straight or branched, saturated o...
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JPH08501572A |
PCT No. PCT/DK93/00311 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Sep. 27, 1993 PCT Pub. No. WO94/07842 PCT Pub. Date Apr. 14, 1994Compounds of formula I wherein Q is a -CH2-, -CH=CH- or -C=C-; U is a C1-C6 alkyle...
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JPH089543B2 |
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JPH085836B2 |
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JPH08793B2 |
4,4,7-trimethyl-3,4,7,8-tetrahydro-2(6H)-naphthalen-one is obtained by an elimination reaction from 3-oxo- alpha -ionol by way of direct addition thereof to a solution of a protonic acid in an inert solvent at an elevated temperature, or...
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JPH07330712A |
PURPOSE: To provide an effective process for producing an active vitamin D3 having excellent differentiation-inducing activity and bone mass-improving activity. CONSTITUTION: A cyclovitamin D3 derivative of formula I is subjected to a pr...
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JPH07116134B2 |
NEW MATERIAL:The compound of formula I [the double line is cis or trans double bond; G<1> is -CO2R<5> (R<5> are H, 1-10C alkyl, etc.), etc.; R<1> is H, methyl, etc.; R<2> is unsubstituted 5-8C alkyl, (substituted) alicyclic group, etc.; ...
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JPH07116092B2 |
A process for the preparation of polyene aldehydes of the formula I …… in which R represents …… where R' has the meaning alkyl, aryl, aralkyl or cycloalkyl and, if desired, can be further substituted and the radicals R'' represen...
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JPH07116133B2 |
Process for preparing vitamin A which is practically free from 2- cis and 6-cis isomers by hydrogenation of vitamin A aldehyde, optionally in the form of a complex with hydroquinone, in the presence of a ruthenium hydride as catalyst.
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JPH07107044B2 |
A process to prepare retinoyl chlorides, e.g., of the following formula (I): under very mild chlorinating conditions by the action of a reagent amount of dimethylchloroformamidinium chloride on a corresponding retinoic acid.
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JPH07103096B2 |
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JPH07100685B2 |
PCT No. PCT/DK86/00081 Sec. 371 Date Mar. 18, 1987 Sec. 102(e) Date Mar. 18, 1987 PCT Filed Jul. 14, 1986 PCT Pub. No. WO87/00834 PCT Pub. Date Feb. 12, 1987.This invention relates to vitamin D analogues represented by the general formul...
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JPH0796497B2 |
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JPH0794451B2 |
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JPH07258207A |
PURPOSE: To provide a new 1 α-lower alkyl vitamin D derivative useful as an agent for the treatment of calcium hypometabolism, dermatic diseases and diseases accompanying cell differentiation function disorder. CONSTITUTION: This compou...
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JPH0791287B2 |
Compounds of the formula (I) wherein R1-R4 is hydrogen or chlorine, R5 is -COOMe or -SO3Me, Me is an alkali metal cation and X is oxygen, sulfur or selenium, photosensitizers for the conversion of tachysterol into previtamin D are descri...
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JPH07508705A |
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 wher...
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JPH07242620A |
PURPOSE: To obtain a vitamin D3 derivative useful as a medicine, having promoting action on osteogenesis. CONSTITUTION: A vitamin D3 derivative is expressed by formula I such as 1a-hydroxy-22[(1-hydroxy-1-methyl)-2-cyclopenten-4-yl-oxyl-...
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JPH0780834B2 |
A process for the recovery of carotenes comprises the steps of transesterification of oil containing carotenes and vacuum distillation, and is characterised in that 0.1% to 50% of edible oil is added to the transesterified oil containing...
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JPH0780865B2 |
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JPH0778031B2 |
PURPOSE:To readily obtain the titled compound useful as a perfume substance in high purity and selectivity, by subjecting cis-gamma-irone to catalytic reducing reaction in an organic solvent in the presence of palladium catalyst. CONSTIT...
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JPH0772170B2 |
This invention relates to a process for making a compound of formula Iin the form of a stereoisomer or mixture thereof, wherein R is hydrogen, lower alkyl; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy l...
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JPH07196604A |
PURPOSE: To provide a method for producing a 1-hydroxylated vitamin D compound, capable of obtaining the compound useful as an important intermediate for physiologically active vitamin D derivatives in a high yield and in a highly stereo...
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