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JPH0662664B2 |
The invention provides new derivatives of vitamin D3 and specifically (22E,24R)-1,24-dihydroxy- DELTA 22-vitamin D3 and (22E,24S)-1,24-dihdroxy- DELTA 22-vitamin D3. The compounds exhibit vitamin D-like activity in their ability to stimu...
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JPH0662559B2 |
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JPH0662558B2 |
The invention relates to ring A-diol units suitable for synthesizing 1 alpha -hydroxyvitamin D compounds by subsequent condensation with appropriate C/D-ring fragments and to methods for preparing such ring A-diol units.
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JPH0655716B2 |
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JPH0655736B2 |
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JPH0655715B2 |
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JPH0653727B2 |
Compounds of the formula wherein A is a 23,24-bisnorsteroid or a 23,24-bisnor-9,10-secosteroid radical, wherein the free valence bond is in the 22-position and wherein any hydroxy groups present are protected; R1 is hydrogen, carboxy, lo...
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JPH0651624B2 |
Novel derivatives of vitamin D2 and more specifically 1alpha,25-dihydroxylated compounds of the vitamin D series. A process for the preparation of such derivatives is also provided as are certain intermediates in such process. The invent...
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JPH0651716B2 |
The invention relates to new coenzyme A and N-hydroxysuccinimidyl esters of all-trans- and 13-cis-retinoic acid and to methods for preparing the same. A new method for preparing all-trans-retinoic acid anhydride is also disclosed.
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JPH0651676B2 |
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JPH06179622A |
PURPOSE: To provide the medicinal agent having an excellent differentiation- inducing action, reduced in the intestinal Ca-absorbing action of vitamin D, and safe even when used for a long period. CONSTITUTION: The differentiation-induci...
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JPH06157498A |
PURPOSE: To obtain a new intermediate having a bone-absorption-suppressing action, bone-forming action and useful in treating bone diseases by using a compound known as Inhoffen-Lythgoe diol as a raw material. CONSTITUTION: A compound ex...
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JPH0641431B2 |
NEW MATERIAL:A compound shown by the formula I [R<1> is 1-10C (substituted) phenyl; Ar is 6-12C (substituted)phenyl; wavy line is single bond and E-form or Z-form based on double bond or a mixture of them]. EXAMPLE:4-p-Fluorophenylmethyl...
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JPH06145085A |
PURPOSE: To provide the new compounds useful as an anti-thrombus agent, an anti-ulcer agent and an anti-tumor agent. CONSTITUTION: The compounds of the formula I or their salts, e.g. 2- decarboxy-2-hydroxymethyl-9β-methyl-carbacyclin. T...
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JPH0637460B2 |
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JPH0635475B2 |
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1 alpha ,25-dihydroxyvitamin D3, the recognized circulating horm...
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JPH0635431B2 |
This invention relates to a process for making a compound of formula Iin the form of a stereoisomer or mixture thereof, wherein R is hydrogen, lower alkyl; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy l...
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JPH0635474B2 |
Production of 26-homo Vitamin D-3 derivatives and intermediates in the production thereof. These compounds express excellent Vitamin-D like activity and could serve in the treatment of various disease states manifesting calcium and phosp...
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JPH06109727A |
PURPOSE: To obtain an immunoassay method for 1,25-dihydroxy vitamin D and a kit used for the method. CONSTITUTION: A competitive binding enzyme immunoassay method for 1,25- dihydroxy vitamin D contained in a sample involving a process in...
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JPH0628724B2 |
Photochemical reactions are conducted using floating polymer beads on the surface of a moving body of water. The polymer bead is impregnated with a reactant, floated on the water in direct sunlight so as to expose the reactant to solar r...
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JPH06107625A |
PURPOSE: To obtain a new 1α,25-dihydroxyvitamin D derivative useful as antiosteoporosis and antiulcer agent. CONSTITUTION: A compound of formula I (R1 and R2 are H or OH-protecting group), e.g. 22-N-2-hydroxy-1α-methylisobutyl-1α,3β-...
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JPH0623184B2 |
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JPH0623185B2 |
A1 alpha -hydroxy vitamin D3 derivative of the formula: where R1 is a hydroxyl group, an amino group or the group: OR min (where R min is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl gro...
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JPH0680626A |
PURPOSE: To obtain a new 22-oxavitamin D derivative having strong differentiating-inducing action, proliferation suppressing action and capable of expecting uses as a antiulcer agent, an antirheumatic agent and 6 treating agent for psori...
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JPH0617331B2 |
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JPH0611752B2 |
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JPH0611721B2 |
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JPH0611751B2 |
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JPH0611753B2 |
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JPH0641058A |
PURPOSE: To provide new compounds useful as a hapten suitable for preparing an antibody in measuring an active type vitamin D metabolite. CONSTITUTION: A compound of formula I (each of R1 and R3 is H or OH; R2 is OH; (n) is 1-5; R4 is a ...
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JPH0610189B2 |
A new class of vitamin D compounds which are characterized by a modified ring A and triene structures are described, especially 7,8-dihydroxy-, 10,19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D3.
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JPH0610188B2 |
Novel derivatives of vitamin D2 and more specifically 1alpha,25-dihydroxylated compounds of the vitamin D series. A process for the preparation of such derivatives is also provided as are certain intermediates in such process. The invent...
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JPH0610187B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0632740A |
PURPOSE: To obtain a medicinal preparation which is effective for treatments, etc., of psoriasis, osteoporosis, precancerosis symptom and ulcer, and consists of 9-cis- or 13-cis-retinoic acid or acytoretins and a vitamin D derivative as ...
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JPH068280B2 |
PCT No. PCT/DE84/00280 Sec. 371 Date Sep. 17, 1985 Sec. 102(e) Date Sep. 17, 1985 PCT Filed Dec. 21, 1984 PCT Pub. No. WO85/02841 PCT Pub. Date Jul. 4, 1985.The invention relates to 9-halo- DELTA 2-prostane derivatives of general Formula...
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JPH068279B2 |
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JPH066569B1 |
A new class of vitamin D compounds which are characterized by a modified ring A and triene structures are described, especially 7,8-dihydroxy-, 10,19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D3.
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JPH066567B2 |
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JPH066568B2 |
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JPH064536B2 |
Novel vitamin D derivatives, analogs of vitamin D2 compounds which lack the 24-methyl substituent and are identified as 1 alpha -hydroxy-28-norvitamin D2 and 1 alpha ,25-dihydroxy-28-norvitamin D2. The compounds of the invention are char...
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JPH064557B2 |
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JPH064556B2 |
1. A process for the preparation of cyclohexanedione derivatives of the general formula see diagramm : EP0124041,P7,F1 where R**1 means one of the following substituents : C2 -C8 -alkyl, C2 -C8 -alkenyl, C3 -C12 -cycloalkyl, C5 -C12 -cyc...
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JPH064552B2 |
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JPH062701B2 |
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JPH062692B2 |
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JPH062704B2 |
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JPH05339230A |
PURPOSE: To enable high-yield production of activated-type vitamin D2 or its derivatives having good differentiation-inducing action and bone mass-improving action through simple process steps. CONSTITUTION: An adduct of ergosterol of fo...
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JPH05331093A |
PURPOSE: To provide the intermediate comprising 1-ethynyl-bicyclo [3,1,0]hexan-2- one and efficiently giving 1,25-dihydroxyvitamin D3 useful for treating chronic renal failure, hypoparathyroidism, osteoporosis, etc. CONSTITUTION: Water-s...
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JPH05320127A |
PURPOSE: To provide a new active-type vitamin D compound excellent in improvement of the bone amount, reduced in side effect and toxicity and useful for improving osteoporosis. CONSTITUTION: An active-type vitamin D derivative represente...
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JPH05508409A |
PCT No. PCT/DK91/00172 Sec. 371 Date Jan. 11, 1993 Sec. 102(e) Date Jan. 11, 1993 PCT Filed Jun. 24, 1991 PCT Pub. No. WO92/01454 PCT Pub. Date Feb. 6, 1992.The present invention relates to the use of 20(R)-22-oxavitamin D analogues for ...
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