Heterocyclic Compounds

Matches 1,351 - 1,400 out of 4,664	< 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 >

Document	Document Title
WO/1997/047602A1	TRICYCLIC AMINE DERIVATIVES Compounds of formula (I) wherein R1 represents a group of formula (A) or (B); R2 represents a hydrogen atom or a C1-4alkyl group; R3 represents a substituent selected from: a hydrogen or halogen atom, a hydroxy, cyano, trifluoromethyl, t...
WO/1997/046528A1	STERICALLY HINDERED 4-AMINO-PIPERIDINE WITH A LOW DIMER CONTENT, ITS PRODUCTION AND USE A process for reducing the dimerisation of piperidine of formula (I) in which R1 to R4 are C1 to C6 alkyl, R1 and R2 and/or R3 and R4 together are a CH2 chain with 2 to 5 C atoms. Said process is characterised in that to the piperidine i...
WO/1997/046533A1	PROCESS FOR PRODUCING PERYLENE-3,4-DICARBOXYLIC ACID IMIDES The production of perylene-3,4-dicarboxylic acid imines of formula (I) (R1 is hydrogen, C1-C8 alkyl, C5-C8 cycloalkyl, possibly substituted phenyl or naphthyl; the radicals R2 are mutually independently hydrogen, C1-C18 alkyl, possibly s...
WO/1997/046529A1	PROCESS FOR PURIFYING STERICALLY HINDERED 4-AMINO PIPERIDINES A process for purifying raw piperidines of formula (I), where R1 to R4 are C1 to C6 alkyl, R1 and R2 and/or R3 and R4 together are a CH2 chain with 2 to 5 C atoms. Said process is characterized in that in an initial step high-boiling-poi...
WO/1997/045403A1	ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of structural Formula (I) where X and Y are at the 5, 6, or 7 position wherein...
WO/1997/045415A1	POLYAMIDE DERIVATIVES OR ORNITHINE, LYSINE AND ANALOGOUS SUBSTANCES WITH CCK-B AND GASTRIN-ANTAGONISTIC ACTIVITY Compounds are described which may be represented by general formula (I) in which: R1 is a simple phenyl group or a phenyl grup mono- or di- substituted with chlorine; R2 is H or CH3; R3 is a heterocyclic spiro ring group represented by (...
WO/1997/044030A1	USE OF SUBSTITUTED AZASPIRANE IN THE TREATMENT OF ASTHMA Invented is a method of treating asthma, in mammals, including humans, which comprises administering to such human an effective amount of a substituted azaspirane.
WO/1997/043290A1	CAMPTOTHECIN-SKELETON COMPOUNDS ISOLATED FROM MAPPIA FOETIDA AND THE USE THEREOF AS SYNTONES FOR NOVEL MEDICAMENTS AS WELL AS THERAPEUTICAL AGENTS The present invention relates to the isolation or the semisynthesis of novel alkaloids of formula (I) present in different parts of Mappia foetida as well as the pharmaceutical use thereof and the use thereof as novel syntones for the pr...
WO/1997/043287A1	CARBOLINE DERIVATIVES Carboline derivatives of formula (I), are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP specific PDE) and have utility in a variety of therapeutic areas where such inhibition is ...
WO/1997/040833A1	HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS Compounds such as formula (A) or pharmaceutically acceptable salts thereof are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, phar...
WO/1997/040016A1	HETEROCYCLIC COMPOUNDS The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic receptor.
WO/1997/040044A1	HETEROCYCLIC COMPOUNDS The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
WO/1997/040015A1	TRICYCLIC AMINOALKYLCARBOXAMIDES; NOVEL DOPAMINE D3 RECEPTOR SUBTYPE SPECIFIC LIGANDS Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof wherein: R1-R4 represent organic or inorganic groups; A represents an alkylene group of 2 to 6 carbon atoms optionally substituted with...
WO/1997/037992A2	SPIRO[CYCLOPENT[B]INDOLE-PIPERIDINES] AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS Novel spiro[cyclopent[b]indole-piperidines], hydrazone intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and i...
WO/1997/035539A2	ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES Corticotropin releasing factor (CRF) antagonists of formula (I) or formula (II): and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
WO/1997/035854A1	NOVEL PHENANTHRIDINES SUBSTITUTED IN THE 6 POSITION Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.
WO/1997/032865A1	NOVEL ARYL GLYCINAMIDE DERIVATIVES, METHOD OF PRODUCING SAID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS The invention relates to novel aryl glycinamide derivatives of formula (I) and their pharmaceutically acceptable salts, in which R1 and R2 together with the N to which they are bound form a ring of one of the formulae (a), (b), (c) or (d...
WO/1997/030977A1	SELECTIVE D1 DOPAMINE RECEPTOR AGONISTS AND PARTIAL AGONISTS/ANTAGONISTS Disclosed are compounds (1) and (2), and derivatives and analogs thereof, which are agonists for the D1 dopamine receptor. These compounds can be used to treat an individual with Parkinson's disease. Also disclosed are monohydroxy analog...
WO/1997/031003A1	CAMPTOTHECIN DERIVATIVES AND THE USE THEREOF AS ANTITUMOR AGENTS Compounds of formula (I), wherein: R1 is -CN, -CH(CN)-R4, -CH=C(CN)-R4, -CH2-CH(CN)-R4, -C(=NOH)-NH2, -C(=NH)-NH2, -CH=C(NO2)-R4, -CH(CN)-R5, -CH(CH2NO2)-R5; 5-tetrazolyl, 2-(4,5-dihydrooxazolyl), 1,2,4-oxadiazolin-3-yl-5-one; R2 is hydr...
WO/1997/030054A1	PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indol...
WO/1997/029405A1	PHOTOGRAPHIC SYSTEM There is described a photographic system wherein development of an exposed photosensitive element is carried out in the presence of a quaternary pyridinium compound which has a fused 5- to 12-member saturated carbocyclic ring attached to...
WO/1997/028131A1	NEW PHENANTHRIDINES Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents.
WO/1997/027179A2	ANTIRETROVIRAL BASES The invention relates to the use of a compound of formula (I), wherein R1 and R2 are independently amino, N-alkylamino, N,N-dialkylamino, cycloalkylamino, amidino, N-lower alkylamidino, N,N-di-lower alkylamidino, guanidino, N-lower alkyl...
WO/1997/026240A1	CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable sa...
WO/1997/023458A1	SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative d...
WO/1997/019927A1	QUINOLINE DERIVATIVES AS NK3 ANTAGONISTS A method for the treatment and/or prophylaxis of conditions characterized by overstimulation of the tachykinin receptors, which method comprises the administration to a mammal in need thereof of an effective, non-toxic, pharmaceutically ...
WO/1997/019929A1	POLYCYCLIC COMPOUNDS Compounds of Formula (I), methods for their preparation, pharmaceutical formulations and use thereof.
WO/1997/018214A1	HEMOREGULATORY COMPOUNDS The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
WO/1997/015558A1	17-ALKYL-7-SUBSTITUTED-4-AZA STEROID DERIVATIVES The novel compounds of the present invention are those of structural formula (I), or a pharmaceutically acceptable salt, or stereoisomer thereof, which are inhibitors of 5'alpha'-reductase, particularly 5'alpha'-reductase type 1. The com...
WO/1997/014418A1	16-SUBSTITUTED-6-AZA-STEROID 5-ALPHA-REDUCTASE INHIBITORS Compounds of formula (I) are inhibitors of 5'alpha'-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, prostatic carcinoma, prostatitis and ...
WO/1997/014681A1	HETEROCYCLIC COMPOUNDS AS H+-ATPASES This invention relates to a compound of formula (I), wherein R1 is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), A is -CONH- or -NHCO-, n is an integer of 0 or 1, and (II) is a group of form...
WO/1997/014672A1	TRICICLIC COMPOUNDS Triciclic compounds represented by general formula (I) which are useful as a remedy for urinary incontinence, wherein R1 represents hydrogen, etc.; and -X1-X2-X3- represents -CR2=CR3-CR4=CR5- (wherein R2, R3, R4 and R5 represent each hyd...
WO/1997/014683A2	PHENANTHRIDINE DERIVATIVES, METHODS OF PRODUCING THEM AND MEDICAMENTS CONTAINING PHENANTHRIDINE DERIVATIVES Disclosed are novel phenanthridine derivatives of general formul� (I) and (II) and the salts thereof. In the formul�, R1 is a hydrogen atom or aromatic carbocyclic or heterocyclic group, and R2 and R3 can be either identical or diffe...
WO/1997/013754A1	NOVEL POLYCYCLIC AMINOPYRIDINE COMPOUNDS AS ACETYLCHOLINESTERASE INHIBITORS, PREPARATION PROCESS AND USE THEREOF Novel polycylic aminopyridine compounds as inhibitors of acetylcholinesterase, process for their preparation and utilization thereof. The polycylic aminopyridine compounds have formula (I) wherein the various radicals have the meanings i...
WO/1997/012853A1	DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such ...
WO/1997/011940A1	SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
WO/1997/011057A1	ARTHROPODICIDAL 1,4-DIHYDROPYRIDINES AND 1,4-DIHYDROPYRIMIDINES Arthropodicidal compounds, compositions and method of use of compounds of Formula (I) or Formula (II) or mixtures of compounds of Formula (I) and Formula (II) are disclosed, wherein each X is F or C1 and Q, Q1, Q2, A, R1, R3, R4 and R10 ...
WO/1997/010819A1	TREATING NIDDM WITH RXR AGONISTS This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPAR'gamma' agonist such as a thiazolidinedione compound.
WO/1997/010813A1	PPAR GAMMA ANTAGONISTS FOR TREATING OBESITY The present invention relates to a method of treating obesity, diabetes and other metabolic disorders in a mammal by administering to the mammal a pharmaceutical composition containing a compound that antagonizes the activity of PPAR'gam...
WO/1997/010218A1	CYCLIC NITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention is directed to novel cyclic nitrones of the formula (I) in which R1 and R2 are each independently represented by a C1-3 alkyl or R1 and R2 together form a C5-6 alkylene ring or a ring of structure (a), Z represents ...
WO/1997/009294A1	CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE Described are carboxylic acid derivatives of formula (I) in which R1 is a tetrazole or nitrile group, a COOH group or a group which can be hydrolysed to COOH, and the other substituents are as defined in the description.
WO/1997/009044A1	PENTACYCLIC COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS The present invention relates to compounds of formulae (I) and (II) wherein X is -O-, -S-, or -NR5-; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR5-; B is -CH2- or -CO-; R1, R2, and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -...
WO/1997/006799A1	NOVEL FUSED ISOQUINOLINES AS DOPAMINE RECEPTOR LIGANDS The present invention is directed to novel dopamine receptor ligands of formula (I), pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related dysfunction of t...
WO/1997/006146A1	METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE The invention concerns a method of preparing norbenzomorphane in the central intermediate stage in the preparation of pharmaceutically useful benzomorphane derivatives of general formula (1), in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2...
WO/1997/006145A1	FUSED INDAN DERIVATIVES AND SALTS THEREOF Fused indan derivatives represented by general formula (1), salts thereof and medicinal uses of the same, wherein the ring A represents an optionally substituted benzene ring or a benzene ring having lower alkylenedioxy; the ring B repre...
WO/1997/003978A1	NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally ...
WO/1997/003979A1	POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 abd R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally ...
WO/1997/003054A1	BENZO[g]QUINOLINE DERIVATIVES The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3 and R4 are as defined in the description, and a process for preparing them. The compounds of formula (I) are useful as pharmaceuticals.
WO/1997/002228A1	PROCESS TO PREPARE 5-FORMYLVALERIC ACID Process to separate linear 5-formylvaleric acid from a mixture of 5- and 3- and 4-formylvaleric acids, wherein the separation is performed by fractional extraction with two immiscible solvents of which one solvent is an aqueous solvent a...
WO/1997/002248A1	AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE Aromatic acid diamide compounds with antigastrin activity are described which may be represented by general formula (I), in which Ar is a phenyl group or an unsubstituted pyridyl group or a pyridyl group mono- or disubstituted with a gro...

Matches 1,351 - 1,400 out of 4,664	< 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 >