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JP3242140B2 |
PURPOSE: To obtain a bactericidal compsn. having an improved effect. CONSTITUTION: A new bactericidal compsn. comprising one or more compound(s) selected from specified 6-aryl-2-(2-'-alkynyl)pyridazinones and/or 6-aryl-2-(2'- alkynyl)-4,...
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JP2001526274A |
This invention provides substituted 1,2,3,4-tetrahydronaphthalene [3H]-emopamil binding site inhibitors useful in the treatment of neurological disorders. Such inhibitors are compounds of formula (I)wherein R, R1, m, R2 and n are as defi...
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JP2001523732A |
The invention provides compositions that include conjugates of a fatty acid molecule, preferably cis-docosahexaenoic acid, and clozapine. The conjugates are useful in treating psychological disorders such as schizophrenia.
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JP2001328938A |
To obtain a pharmaceutical containing a cyanophenyl derivative as an active ingredient which exhibits antiandrogen activity and is useful in the prophylaxis or treatment for prostatic cancer, prostatic hypertrophy or the like.This cyanop...
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JP2001522849A |
A compound of Formula I: or a pharmaceutically acceptable salt thereof, which is antimicrobial agents, effective against various human and veterinary pathogens, including gram positive aerobic organisms, gram negative organisms, and anae...
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JP2001316379A |
To obtain a compound useful as a functional material, and further to provide a method for producing the compound, and an organic EL element by using the compound.This compound is represented by formula (I) or (II) (wherein, X1 and X2 are...
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JP2001521522A |
Halo-alkoxycarbonyl derivatives are provided as prodrug moieties for pharmaceutical agents containing a basic or polar nitrogen containing functionality. The prodrugs are provided as pharmaceutical compositions as well as in methods of t...
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JP2001520197A |
This invention is concerned with novel compounds represented by structural formula (I) which are useful in the treatment of arrhythmia.
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JP2001520215A |
The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the inv...
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JP3222599B2 |
PURPOSE: To obtain a benzodiazepine derivative, having excellent selective antagonistic action on gastrin receptor and useful as a therapeutic agent for diseases related to the gastrin such as gastric ulcer without any side effects on th...
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JP2001519335A |
A process for the preparation of asymmetric cyclic ureas of Formula (VI) starting from the diamine of Formula (I). In the process, a compound of Formual (I), wherein G is a group selected from -C(-CH2CH2CH2CH2CH2-)-, -C(CH2CH3)2-, -C(CH3...
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JP2001519387A |
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of formulas (I), (II), their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates th...
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JP2001519396A |
Pharmaceutical formulations, particularly suitable for treating chronic and neuropathic pain comprise an opioid-potentiating amount of a CCK antagonist and an analgesic amount of an opioid in a pharmaceutically acceptable biphasic carrie...
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JP2001519763A |
(57) [Summary] The present invention relates to methods useful in combinatorial chemistry. More specifically, the present invention relates to a method for synthesizing a spatially dispersed position-coded combination chemical oligomer l...
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JP2001518507A |
Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
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JP3215910B2 |
PURPOSE: To obtain a benzohetero ring derivative having excellent antagonistic action on vasopressin and oxitocin and operation on vasopressin, useful for preventing and treating a vasopressin dyschylia syndrome, an oxitocin-related dise...
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JP3216136B2 |
Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formulae:
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JP3215338B2 |
To produce a new aminobenzenesulfonic acid derivative monohydrate useful for producing a medicinal composition effective in preventing or treating ischemic cardiopathy, cardiac failure and hypertension, etc. This new aminobenzenesulfonic...
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JP2001261657A |
To provide a cyanophenyl derivative having an anti-androgen activity and useful for the prevention and treatment of prostate cancer, prostate hypertrophy, etc.This cyanophenyl derivative is piperzino-substituted new cyanophenyl derivativ...
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JP3208140B2 |
A compound of formula or a pharmaceutically acceptable salt form thereof, is useful as a retrovial protease inhibitor for treating HIV infections.
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JP2001513565A |
Compounds of structural formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, a...
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JP2001513766A |
PCT No. PCT/EP98/00986 Sec. 371 Date Aug. 25, 1999 Sec. 102(e) Date Aug. 25, 1999 PCT Filed Feb. 20, 1998 PCT Pub. No. WO98/38175 PCT Pub. Date Sep. 3, 1998A 1,4-diazacycloheptane derivative and an oxidative hair colorant containing the ...
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JP2001513107A |
Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits...
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JP3199890B2 |
PURPOSE: To obtain a novel compound having a gastrin receptor-antagonizing action and a histamine H2 receptor-antagonizing action and useful as an ulcer therapeutic agent capable of reducing the relapse of the ulcer after cured. CONSTITU...
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JP3188715B2 |
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, di...
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JP3176365B2 |
A novel benzenesulfonamide derivative of formula (I) which has an action of inhibiting phospholipase A2 and therefore is effective in treating diseases for which this action is used to advantage.
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JP2001507231A |
The present invention involves enantiomerically pure benzodiazepine acetic acid esters and methods of preparing them by resolving a racemic mixture utilizing a lipase.
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JP2001506978A |
The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using suc...
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JP3170292B2 |
A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
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JP2001139562A |
To provide a method for simply and profitably producing a 6- amino-1,4-dialkylhexahydro-1H-1,4-diazepine derivative in a high yield. This method for producing a 6-amino-1,4-dialkylhexahydro-1 H-1,4-diazepine derivative comprises reacting...
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JP2001506606A |
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula:wherein X is O or NR<9 >and R<1>-R<4>, R<6>-R<9>, R<11>, R<12>, R, R, R, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or ...
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JP3167770B2 |
((2-Amino-3,4-dioxo -1-cyclo-buten-1-yl) amino)alkyl)acid derivs. of formula (I) and their salts are new: R1 = H, 1-6C alkyl or 7-12C phenylalkyl; R2 = H, 1-6C alkyl, 2-6C alkenyl or 7-12C phenylalkyl; or R1 + R2 = Z; Z = -CH2CH2-, -CH2C...
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JP3166782B2 |
PURPOSE: To provide a new compd. for fungicide, especially useful for agricultural fungicide. CONSTITUTION: The compd. represented by formula I (the ring formed with D-NR1-A is dihydropyridazin-3-one, pyridazin-3-one, etc.; R1 is a lower...
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JP2001089461A |
To provide a novel production process that can simply obtain a specific tetrahydronaphthodiazepine in high yield and provide a novel production process that can simply obtain a specific squalirium dye. A tetrahydronaphthodiazepine repres...
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JP2001504454A |
Benzodiazepine derivatives of the formula: wherein R1 is heterocyclic(lower)alkyl which may have one or more suitable substituent(s), etc., R2 is lower alkyl, etc., R3 is indolyl, etc., R4 is hydrogen, etc., or a pharmaceutically accepta...
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JP2001072618A |
To produce a halogenated benzene compound useful for producing a compound containing a radioactive halogen in the molecule by reacting a specific organometallic compound with a halide ion in the presence of a specified semiconductor cata...
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JP2001503428A |
The present invention relates to compounds of formulae (I) and (II), or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits co...
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JP2001501951A |
A method for stimulating bone formation by administering integrin binding compounds which cause the release of osteocalcin from osteoblasts is disclosed.
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JP3131767B2 |
To obtain the subject new compound useful as an active ingredient of a pharmaceutical composition used for treating diseases such as myopalmus by substituting a 2,3-benzodiazepine with one or two halo atoms. This new compound is represen...
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JP3128750B2 |
To obtain the subject new benzodiazepine derivative that is prepared by reaction of 2-benzopyrylium perchlorate with a hydrazine, has the anxiolytic effect, neurotropic effect, and antiaggressive effect and is useful for therapy of centr...
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JP2000351768A |
To obtain the subject new compound exhibiting excellent vasopressin antagonism, oxytocin antagonism and vasopressin agonistic action, therefore useful as e.g. a vasodilator, hypotensive, diuretic, platelet coagulation inhibitor.This new ...
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JP3117717B2 |
PCT No. PCT/SE92/00690 Sec. 371 Date Apr. 1, 1994 Sec. 102(e) Date Apr. 1, 1994 PCT Filed Oct. 2, 1992 PCT Pub. No. WO93/07429 PCT Pub. Date Apr. 15, 1993.A foodstuff air treatment device includes a housing (1) with an elongated trough (...
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JP2000516596A |
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.
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JP2000516629A |
Described herein are compounds of general formula (I), a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, wherein: R1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C1-4al...
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JP2000516252A |
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhi...
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JP2000319249A |
To obtain a new compound useful as a medicine for treating or preventing virus infection, especially cytomegalovirus infection. A compound of formula I [R1 is H, a (substituted) 6 to 10C aryl, (five to ten-membered aromatic heterogeneous...
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JP2000515506A |
PCT No. PCT/US97/11564 Sec. 371 Date Apr. 14, 1999 Sec. 102(e) Date Apr. 14, 1999 PCT Filed Jul. 8, 1997 PCT Pub. No. WO98/01132 PCT Pub. Date Jan. 15, 1998The present invention relates to specific adamantyl or adamantyl group derivative...
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JP2000515166A |
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhi...
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JP2000513374A |
The present invention discloses new processes in the preparation of midazolam (VII), a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.
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JP3083842B2 |
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of select...
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