Heterocyclic Compounds

Matches 951 - 1,000 out of 4,506	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >

Document	Document Title
WO/2004/064771A2	GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or ...
WO/2004/065372A1	TETRAZOLE-FUNCTIONALIZED AMINO ACIDS, THEIR PRODUCTION AND USE The present invention relates to novel tetrazole-functionalized amino acids of formula (I) and pharmaceutically acceptable salts thereof as well as their production and use.
WO/2004/063181A1	UREA DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS The present invention provides compositions and their use in the treatment of inflammatory diseases caused by T-cell proliferation such as sepsis, inflammatory bowel diseases, autoimmune encephalomyelitis, or lupus. The compositions comp...
WO/2004/058164A2	ASTHMA AND ALLERGIC INFLAMMATION MODULATORS Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/...
WO/2004/056735A1	2,6-DIHALO-4-(3,3-DICHLORO-ALLYLOXY)-BENZYLALCOHOLE DERIVATIVES HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES Compounds of formula (I), wherein: A1 is, for example, a bond or a C1-C6alkylene bridge; A2 is, for example, a bond or C1-C6alkylene; A3 is, for example, C1-C6alkylene; W is, for example, O or S; T is, for example, a bond, O, NH, NR7, S,...
WO/2004/056744A1	ADAMANTYL ACETAMIDES AS HYDROXYSTEROID DEHYDROGENASE INHIBITORS formulae (I)the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R...
WO/2004/056745A2	ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alky...
WO/2004/056727A2	PROCESS OF MAKING CHALCONE DERIVATIVES This invention is a novel methods of manufacturing chalcones that includes reacting a carbon-linked heteroaryl or heterocyclic substituted benzaldehyde with an acetophenone in a solvent or mixture of solvents in the presence of LiOMe. Al...
WO/2004/052840A1	COMPOUNDS WHICH MODULATE PPAR&gammad TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS The invention relates to novel compounds that correspond to the general formula (I) below and to a method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatolog...
WO/2004/050643A2	NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Disclosed herein are compounds of formula Ar1-X-W-Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl group...
WO/2004/048309A1	VITAMIN D RECEPTOR MODULATORS The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disea...
WO/2004/046095A1	SUBSTITUTED ARYL THIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antivira...
WO/2004/046090A2	ARYL UREIDO DERIVATIVES AND THEIR MEDICAL USE This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are...
WO/2004/039762A1	PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...
WO/2004/039753A2	PHENYL COMPOUNDS Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds an...
WO/2004/035552A1	ALPHA-PHENYL ACETANILIDE DERIVATIVES HAVING AN ACAT INHIBITING ACTIVITY AND THE THERAPEUTIC APPLICATION THEREOF The invention relates to novel derivatives having general formula (I), wherein R1 represents an amino or hydroxyl group, R2 represents hydrogen or a methyl radical, R3 represents hydrogen or a fluorine atom and A represents: group a, for...
WO/2004/031139A1	CYCLOHEXYL SULPHONES AS GAMMA-SECRETASE INHIBITORS Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
WO/2004/031137A1	CYCLOHEXYL SULPHONE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in treatment of Alzheimer's disease.
WO/2004/026847A1	PROCESS FOR THE MANUFACTURE OF VALSARTAN The present invention relates to a process for the manufacture of Valsartan, an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and ...
WO/2004/022525A1	AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS The present invention relates to novel amide derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic disea...
WO/2004/021996A2	BACKBONE-SUBSTITUTED BIFUNCTIONAL DOTA LIGANDS, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING SAME Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N',N'',N''' -tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in diagnostic imaging and treatment of a cellular disor...
WO/2004/022529A2	DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as f...
WO/2004/020445A2	4-(3,3-DIHALO-ALLYLOXY) PHENOL DERIVATIVES HAVING PESTICIDAL PROPERTIES Compounds of formula (I) wherein Ao is a bond or a C1-C6alkylene bridge; A1, A2 and A3 are a C1-C6alkylene bridge; D is CH or N; W is, for example, O, S, SO, S02, -C(=O)-O- or -O-C(=O)-; T is a bond or, for example, O, NH, S, SO or SR2; ...
WO/2004/020393A1	DIBENZYLAMINE COMPOUND AND MEDICINAL USE THEREOF A dibenzylamine compound represented by the general formula (1): (1) (wherein R1 and R2 each is optionally halogenated C1-6 alkyl, etc.; R3, R4, and R5 each is hydrogen, halogeno, etc., provided that R3 and R4 may form an optionally subs...
WO/2004/018386A2	ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders assoc...
WO/2004/018461A2	ANTIBACTERIAL BENZOIC ACID DERIVATIVES The present invention relates to antibacterial agents that are useful for sterilization, sanitation, antisepsis, disinfection, and treatment of antibacterial infections in mammals.
WO/2004/014316A2	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
WO/2004/014317A2	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
WO/2004/014366A1	HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein Rl, Q, S, T, U, V, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprisi...
WO/2004/012726A2	METHODS FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL CONDITIONS Therapeutic methods for the prevention ad treatment of conditions and diseases of the gastrointestinal tract involving an overproduction of nitric oxide by inducible nitric oxide synthase are described, the methods including administerin...
WO/2004/009563A1	5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR The present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a 5-Aryltetrazole Compound, and methods for treating an inflammation disease, a reperfusion disease, or hyperuricemia in an animal...
WO/2004/009533A1	ACETYLAMINO BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by mo...
WO/2004/007439A1	BIARYL DERIVATIVES A compound represented by the following general formula or its salt has an agonistic activity to peroxisome proliferator activated receptor &dgr (PPAR&dgr ) and, therefore, is useful as an agent elevating blood high density lipoprotein (...
WO/2004/006934A2	1,4,7,10-TETRAAZACYCLODODECANES AS MODULATORS OF THE GUANINE-BINDING PROTEIN FOR TREATING TUMOURS The invention relates to substituted and unsubstituted 1,4,7,10-tetraazacyclododecanes of the below mentioned formulae as medical active ingredients and which bind to Ras proteins, thereby causing a conformation change in the protein whi...
WO/2004/007455A1	HETEROCYCLICALLY SUBSTITUTED BENZOYLUREAS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS The invention relates to heterocyclically substituted benzoylureas, in addition to their physiologically compatible salts and physiologically functional derivatives. The invention relates in particular to compounds of formula (I), in whi...
WO/2004/005229A1	MODULATORS OF THE GLUCOCORTICOID RECEPTOR The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of an...
WO/2004/002462A2	USE OF AN ALPHA2DELTA LIGAND SUCH AS GABAPENTIN OR PREGABALIN FOR TREATING TTENTION DEFICIT HYPERACTIVITY DISORDER This invention relates to a method of treating ADHD by administering an alpha2delta ligand such as, for example, gabapentin or pregabalin, or a pharmaceutically acceptable salt thereof.
WO/2004/002549A1	USE OF ORGANIC COMPOUNDS The present invention relates to drug delivery systems, comprising an ARB or a RI, or at least two representatives selected from the group consisting of an ARB, an ACEI and a RI, or, in each case, a pharmaceutically acceptable salt there...
WO/2004/002944A1	INHIBITORS OF HCV NS5B POLYMERASE The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
WO/2004/002940A1	INHIBITORS OF HCV NS5B POLYMERASE The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
WO/2004/000826A1	PROCESSES FOR PRODUCING EPOXYTRIAZOLE DERIVATIVE AND INTERMEDIATE THEREFOR A compound represented by the following formula (I) is reacted with a trimethyloxosulfonium salt, etc. in the presence of a base to obtain a compound (II). The compound (II) is converted into a compound (IV). The compound (IV) is reacted...
WO/2003/105853A1	1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazin...
WO/2003/106436A1	NEMATICIDAL TETRAZOLE-CONTAINING TRIFLUOROBUTENES The present invention relates to novel tetrazole-containing trifluorobutene derivatives of the formula (I) wherein R represents alkyl, alkenyl, haloalkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, optionally substituted phenyl or optional...
WO/2003/103722A1	NEW AGENTS FOR MAGNETIC IMAGING METHOD The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer; m is an integer and p is an integer. The...
WO/2003/097050A2	A SELECTIVE INOS INHIBITOR AND A PDE INHIBITOR IN COMBINATION FOR THE TREATMENT OF RESPIRATORY DISEASES Therapeutic methods for the prevention and treatment of respiratory diseases or conditions are described, the methods including administering to a subject in need thereof a respiratory disease or condition effective amount of a selective...
WO/2003/097163A2	USING A SELECTIVE INOS INHIBITOR FOR THE TREATMENT OF RESPIRATORY DISEASES AND CONDITIONS Therapeutic methods for the prevention and treatment of respiratory diseases or conditions are described, the methods including administering to a subject in need thereof a respiratory disease or condition effective amount of a selective...
WO/2003/097045A1	COMBINATION OF ORGANIC COMPOUNDS The present invention relates to a combination of organic compounds, a pharmaceutical composition and a kit of parts comprising said combination of organic compounds and to a method of treatment or prevention of certain conditions or dis...
WO/2003/097619A1	GLUCAGON ANTAGONISTS/INVERSE AGONISTS A novel class of compounds of the general formula (I), which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the...
WO/2003/095398A2	POLYDIAZENIUMDIOLATED CYCLIC POLYAMINES WITH POLYPHASIC NITRIC OXIDE RELEASE AND RELATED COMPOUNDS, COMPOSITIONS COMPRISING SAME AND METHODS OF USING SAME The present invention provides compound of the Formula (I); in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biol...
WO/2003/092670A1	BOMBESIN ANTAGONISTS Compounds of formula (I): and their salts, solvates, prodrugs, etc., wherein teh substituents have the values mentioned herein, are bombesin antagonists, which have utility in variety of therapeutic areas including male and female sexual...

Matches 951 - 1,000 out of 4,506	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >