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Patent Searching and Data


Matches 1,001 - 1,050 out of 11,171

Document Document Title
WO/2006/110155A1
Novel crystalline forms of Linezolid, designated as Form TIII, Form V, Form VI, Form IX, Form X, Form XII, Form XIV, Form XVII, and Form XVIII, are disclosed. The novel crystalline forms are characterized by powder X-ray diffraction, FTI...  
WO/2006/108493A1
A process for preparing oxazole carboxylic esters of the formula (I) in which Ar is aryl or heteroaryl, Rl is H or alkyl and R2 is alkyl or aryl, which comprises converting an oxazole nitrile of the formula (II) in which Ar and Rl are as...  
WO/2006/108591A1
The present invention relates to l H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as AMPA-receptor ligands, in particular for the treatment of epilepsy or schiz...  
WO/2006/109817A1
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 represents a branched alkyl group having 3 to 9 carbon atoms or the like; R2 represents a 6-membered heteroaryl group having 1 or 2 n...  
WO/2006/106437A3
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinas...  
WO/2006/106437A2
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinas...  
WO/2006/103057A1
The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(C...  
WO/2006/104594A3
Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmac...  
WO/2006/105051A2
Disclosed herein are methods for synthesizing diketopiperazines with enantiomeric excess by inducing cyclization of an α- keto acid with an acid catalyst.  
WO2006059245A3
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing CNS and amyloid associated disease. Also described are methods, compounds, pharmaceutical compositions and kits for detecting, diagnosing, ...  
WO/2006/104755A3
A pretreatment composition for treating a substrate to be subjected to forming a relief pattern thereon by exposure to actinic radiation, the pretreatment composition comprising: (a) at least one compound having Structure (VI), wherein, ...  
WO/2006/105051A3
Disclosed herein are methods for synthesizing diketopiperazines with enantiomeric excess by inducing cyclization of an α- keto acid with an acid catalyst.  
WO/2006/103045A1
The present invention relates to compounds comprising an oxazole or thiazole moiety of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3 -receptor ligands, Formula (I), ...  
WO/2006/105217A2
Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, ...  
WO/2006/102674A2
Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivative are described, as are pharmaceutical compositions containing these compound and their use for preparing medicaments for the treatment of hypercholesterolemia  
WO2005013914A8
The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and met...  
WO/2006/096994A1
The present invention relates generally to perfluoroalkyl chiral auxiliary compounds and methods of manufacture. These compounds have the functionality to effectively support the synthesis of chiral compounds in single reactions, high-th...  
WO/2006/094770A2
The invention relates to an apparatus for the final processing of a forming tool (5, 7) for a sheet-metal body part, in which, in a first operation for identifying a surface region (45) of a tool surface (9, 11) to be reworked, a sheet-m...  
WO/2006/096584A1
The present invention relates to processes for the preparation of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl- benzoxazol-5-ol. The processes include the vinylation of a substituted benzoxaz...  
WO/2006/094682A1
This invention is concerned with compounds of the formula (I) wherein A, B1, B2, R1, R2 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical co...  
WO/2006/094923A1
The invention relates to a sensor element for determining particles in gaseous mixtures, in particular for carbon black sensors. The element comprises a ceramic sensor body, into which a heating element is integrated, in addition to a fi...  
WO2006034296A3
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.  
WO/2006/094602A1
The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, and q have the designations cited in patent claim 1. Said compounds can be used, inter alia, for the treatment of tumours.  
WO/2006/096591A1
The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3- fluoro-4-hydroxyphenyl)-7-vinyl-l,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abno...  
WO/2006/096624A1
The present invention provides processes for the purification of substituted benzoxazole compounds of formla (I), and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl- benzooxazol-5-ol. The processes include recrystallizing the compou...  
WO/2006/094236A1
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treatin and/or preventing a wide variety of diseases and disorders...  
WO/2006/092074A1
A compound of the formula (I) in which X and Y are selected as defined in the description. The compounds have cooling properties and are useful in, for example, foodstuffs , dentifrices and cosmetics .  
WO/2006/093354A1
Disclosed are a novel production intermediate of (S)-2-[3-(N-&lcub [4-(4-fluorophenoxy)phenyl]methyl&rcub carbamoyl)-4-methoxyphenylmethyl]butanoic acid (compound 1), and a method for producing the same. Specifically disclosed is benzyl ...  
WO2006066133A3
Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formula: wherein the variables are as defined herein.  
WO/2006/090792A1
A haloalkylsulfonanilide derivative represented by the formula (I): &lcub wherein R1 represents haloalkyl; R2 represents H, alkylcarbonyl, optionally substituted phenylcarbonyl, alkoxycarbonyl, optionally substituted phenoxycarbonyl, opt...  
WO/2006/091848A2
The present invention provides an isolated linezolid (1) impurity, bis-linezolid (4), preparation thereof and its use as a reference standard.  
WO/2006/090235A1
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, arylox...  
WO/2006/091731A2
The present invention provides improved methods of converting R-N-(4-morpholiyl- 3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl azide (III) to the intermediate S-N-(4- morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine (II) that ...  
WO/2006/090768A1
A process for producing a compound (4) comprising the step of reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1) comprising the step of reacting a compound (2) with a compoun...  
WO/2006/091669A1
Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-canc...  
WO/2006/091777A1
The present invention relates to novel crystalline forms of the linezolid intermediate S-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-meth yl amine referred to herein as Form A, Form B, and Form C.  
WO2005004810A3
N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.  
WO2005108380A3
A process is provided which employs reactive controlled crystallization to produce drug substance having desirable crystal properties which process involves providing reactants A and B in liquid or solution form and adding reactant B to ...  
WO2005116002B1
The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the com...  
WO2005097114A3
The present invention relates to compounds of the Formula (I) wherein R1, R2, R3, R4, m, n and p are as defined. Compounds of the Formula (I) have activity inhibiting production of Aß-peptide. The invention also relates to pharmaceutica...  
WO/2006/086705A1
The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, an...  
WO2005107762A3
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.  
WO/2006/085510A1
A remedy for IBS comprising, as the active ingredient, a dual antagonist for 5-HT2B and 5-HT7 receptors which shows selective binding affinities to 5-HT2B and 5-HT7 receptors. The above-described medicinal composition is superior in the ...  
WO/2006/083271A2
The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhi...  
WO/2006/082597A2
The present invention discloses crystalline Polymorphic Form I of compound 5-(3,5- dimethylphenoxy-) methyl)-2-oxazolidinone, characterized by x-ray diffraction pattern having peaks at 10.355, 14.285,18.625, 19.030, 20.810 and 22.475± 0...  
WO/2006/083781A1
Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-p...  
WO2006044415A3
Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed.  
WO/2006/083924A1
1-Acylamino-2-hydroxy-3-amino-&ohgr -arylalkanes of formula I. and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.  
WO/2006/082495A1
The present invention relates to novel acetic acid derivatives as peroxisome proliferator activated receptor (PPAR) modulators. Compounds described herein can be useful to inhibit or prevent diabetes or diabetes associated complications ...  
WO2005060456A8
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  

Matches 1,001 - 1,050 out of 11,171