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Patent Searching and Data


Matches 1,001 - 1,050 out of 5,609

Document Document Title
WO/2005/116018
The invention provides compounds of the general formula (I), racemic mixtures, optical isomers, pharmaceutically acceptable salts, solvates and pharmaceutical compositions thereof. The definitions of substituents in the general formula (...  
WO/2005/116002
The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the com...  
WO/2005/112945
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among man...  
WO/2005/112913
Dibenz&ogr furan-4,6-dicarboxylic acid core structures having an aromatic substituent appended onto the at the C1 position using three different types of linkages are disclosed herein and shown to afford exceptional amyloidogenesis inhib...  
WO/2005/113490
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfone-c...  
WO/2005/113542
The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer’s Disease. Compounds of particular interest are defined by Formula (I), wherein R4, R5, R6, R7 and R8 are as...  
WO/2005/113522
In accordance with the present invention, compounds of formula (I) that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Ty...  
WO/2005/113521
An improved process of preparing substituted carbamate derivatives, and crystalline forms thereof, useful for the treatment of dyslipidemia and diabetes, and intermediates thereof are provided.  
WO/2005/113523
Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are benzoxazoles and r...  
WO/2005/113520
The present invention relates to trifluorphenyl oxazolidinones of formula (I) and to the process for the synthesis of the same. The compounds of the present invention are useful antimicrobial agents, effective against a number of human a...  
WO/2005/113558
A simple and effective stereocontrolled synthesis of salinosporamide A (1) has been developed which follows the pathway outlined in the Figure. The process, the first total synthesis of salinosporamide A, is capable of providing the comp...  
WO/2005/110990
The invention relates to the compounds of general formula (1), wherein the groups n, A, B, R1, R2 and R3 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of...  
WO/2005/108380
A process is provided which employs reactive controlled crystallization to produce drug substance having desirable crystal properties which process involves providing reactants A and B in liquid or solution form and adding reactant B to ...  
WO/2005/107464
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.  
WO/2005/107762
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.  
WO/2005/105764
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...  
WO/2005/103020
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as...  
WO/2005/103017
A method for preparing a powder being improved in the rate of dissolution, characterized in that it comprises converting a slightly soluble drug having an acidic group (for example, 3-(5-&lcub 2-[5-methyl-2-(4-methylphenyl)-1,3-oxazole-4...  
WO/2005/103012
Compounds represented by the general formula (I) and having cysteine protease inhibiting activity, salts, solvates, or N-oxides thereof, or prodrugs of them; and preventive and/or therapeutic agents for diseases in which cysteine proteas...  
WO/2005/099687
Disclosed herein are analogs of Salinosporamide A, having the Formulae Ia - IVa as follows: [insert chemical formula here] Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzym...  
WO/2005/100329
New protecting reagents are provided that allow for the selective placement of a new protecting group onto a reactive site of a multifunctional compound. The reagents are 2, 3, and 4-trialkylsilylxylyl, triarylsilylxylyl or a combination...  
WO/2005/100334
The invention provides compounds of Formula (I) or prodrugs thereof, or pharmaceutically acceptable salts of said compounds or prodrugs, or solvates of said compounds, prodrugs or salts, wherein A, N, X and R1 are as defined herein; phar...  
WO/2005/100318
The present invention relates to alkanoic acids and their derivatives, which have PPAR agonist activity, and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used for the treatment of diabetes and diabetes-a...  
WO/2005/097765
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. T...  
WO/2005/097114
The present invention relates to compounds of the Formula (I) wherein R1, R2, R3, R4, m, n and p are as defined. Compounds of the Formula (I) have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutica...  
WO/2005/097784
The invention relates to novel phenylthioacetic acid derivatives of formula (I), to a method for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases, in addition to the use thereof in the productio...  
WO/2005/096734
Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.  
WO/2005/095365
The present invention relates to compounds of the Formula (I), wherein R1, R3, R5, R6 and R7 are as defined. Compounds of the Formula (I) have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical co...  
WO/2005/095334
The present invention relates to compounds of the Formula (I), wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula (I) have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical com...  
WO/2005/095364
A novel compound having excellent PPAR&agr /&gammad agonistic activity and having desirable properties required of medicines. It is a peroxisome proliferation-activated receptor &agr /&gammad agonist represented by the following general ...  
WO/2005/095363
A novel compound having excellent PPAR&agr /&gammad agonistic activity and having desirable properties required of medicines. It is a peroxisome proliferator-activated receptor &agr /&gammad agonist represented by the following general f...  
WO/2005/095350
Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.  
WO/2005/092845
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists...  
WO/2005/092899
The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a metho...  
WO/2005/090339
The present invention provides novel compounds of the general formula (I) and their pharmaceutically acceptable salts. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).  
WO/2005/090297
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC is -NR1R2, RA is a group having the formula (A), (B) or (C) RB is h...  
WO/2005/090298
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzo...  
WO/2005/090292
The invention relates to a compound having general formula (I), wherein: A is selected from among one or more X, Y and/or Z groups; X represents an optionally-substituted methylene group; Y represents a C2-alkenylene, optionally substitu...  
WO/2005/090302
The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I); wherein: X, R and R1 are defined here...  
WO/2005/087232
The present invention relates to bicyclic compounds according to formula (I), pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as ...  
WO/2005/087235
A compound of the following formula (I) wherein R1, R2, R3, R4, R5, R6, W, X, Y, Z, m, n, and p are as defined herein. This invention also covers methods for inhibiting dipeptidyl peptidase IV or VIII, or treating Type II diabetes with s...  
WO/2005/087752
The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disord...  
WO/2005/089025
Disclosed is an organic electroluminescent device (organic EL device) which has a simple structure and utilizes phosphorescence. The organic electroluminescent device is improved in luminous efficiency and secured of sufficient driving s...  
WO/2005/085221
The invention relates to $g(b)-ketoamide compounds of general formula (I) wherein the groups and radicals A, B, b, X, Y, Z, R1, R2, R3, R5a and R5b have the designations cited in patent claim 1. The invention also relates to medicaments ...  
WO/2005/085218
The present invention relatesto a novel process for making 4-[5-methyl -3-phenylisoxazol-4-yl] benzenesulphonamide  
WO/2005/084349
Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.  
WO/2005/084349
Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.  
WO/2005/082900
The present invention relates to novel oxazolidinone amidoximes of formula (I) wherein R2, Y1, Y2, Y3, X, W, and Z are as defined herein in the specification. The compounds of the present invention have potent activities against gram-pos...  
WO/2005/082871
The invention relates to guanidine compounds of general formula (I), corresponding enantiomeric, diastereomeric, and/or tautomeric forms thereof, and pharmaceutically acceptable salts thereof. The invention further relates to the use of ...  
WO/2005/083771
An assembly of a semiconductor die attached to a substrate is made with a composition comprising compounds that contain an oxazoline functionality and an electron acceptor or an electron donor functionality. Electron donor functionalitie...  

Matches 1,001 - 1,050 out of 5,609