Heterocyclic Compounds

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Document	Document Title
WO/2013/068554	NEW CYCLOHEXYLAMINE DERIVATIVES HAVING BETA 2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respirato...
WO/2013/068463	SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN N-CYCLIC GROUP AS VANILLOID RECEPTOR LIGANDS The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an N-cyclic group as vanilloid receptor ligands formula (S) to pharmaceutical compositions containing these co...
WO/2013/071093	PYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various dise...
WO/2013/068552	NEW CYCLOHEXYLAMINE DERIVATIVES HAVING β2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respirato...
WO/2013/068470	INHIBITORS OF PHOSPHODIESTERASE TYPE 10A The present invention relates to novel compounds of the formula (I) which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medica...
WO/2013/068935	2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2- yl)picolinamide derivatives of formula (I) Formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their preparation, to ph...
WO/2013/068875	2-THIOPYRIMIDINONES Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.
WO/2013/068489	HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A Novel inhibitor compounds of phosphodiesterase type 10A The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for tr...
WO/2013/071085	PYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various dise...
WO/2013/069765	NITROGENATED HETEROCYCLIC COMPOUND Provided are: a nitrogenated heterocyclic compound represented by formula (I-A)(wherein R1A represents a lower alkyl group which may be substituted by a lower alkoxy group; R3A represents a fluorine-substituted lower alkyl group; and R4A...
WO/2013/070910	REDUCING TRANSMISSION OF SEXUALLY TRANSMITTED INFECTIONS Described herein are compositions and methods for treating or preventing a sexually transmitted infection in a subject
WO/2013/064461	COMPOUNDS WITH NEMATICIDAL ACTIVITY The present invention relates to the use of predominantly known pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.
WO/2013/066684	AMINOPYRIMIDINE KINASE INHIBITORS Disclosed are aminopyrimidine compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK 1, CKIyl, CKIy2, CKIy3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pa...
WO/2013/065063	ANHYDROUS FORM OF DASATINIB, PROCESS FOR ITS PREPARATION AND ITS USE The present invention provides a novel anhydrous form of Dasatinib and process for the preparation thereof. The present invention also provides a process for the preparation of Dasatinib monohydrate using novel anhydrous form.
WO/2013/064518	PESTICIDAL COMPOUNDS A compound of formula (I), wherein R1 to R4 are, for example, each hydrogen, R5 is, for example, an unsubstituted aromatic 6-membered heterocycle; R6 is, for example,hydrogen; R7 is,for example, hydrogen, cyano, hydroxyl, formyl, C1-C4-a...
WO/2013/066869	PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, X3, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of d...
WO/2013/064983	BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-medi...
WO/2013/064984	BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
WO/2013/064231	SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administration of these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present ...
WO/2013/060744	COMPOUNDS HAVING AN ETHR INHIBITING ACTIVITY - USE OF SAID COMPOUNDS AS DRUGS - PHARMACEUTICAL COMPOSITION AND PRODUCT CONTAINING SAID COMPOUNDS The present invention relates to compounds of Formula (I), wherein R1 is chosen among the following radicals : (II); (III); (IV), (V), (VI) (VII) and n= 1 or 2 and m=1 or 2 with the proviso that m=2 when R1 is (VIII). The present inventi...
WO/2013/061081	ANTICANCER BENZOPYRAZINES VIA THE INHIBITION OF FGFR KINASES The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e....
WO/2013/061973	HETEROARYL SULFONAMIDE COMPOUND OR SALT THEREOF Provided is a novel herbicide having excellent herbicidal activity on undesirable plants. The heteroaryl sulfonamide compound or salt thereof has a structure represented by general formula (I): [in the formula, A is an oxygen atom, sulfu...
WO/2013/059928	HIV PROTEASE INHIBITORS Compounds of Formula I are disclosed: wherein A, R1, R2, R3, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors. The compounds and their pharmaceutically...
WO/2013/062065	AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE The objective of the present invention is to provide a compound having inhibitory activity against an intestinal phosphate transporter (NPT-IIb), and useful as an active ingredient in a hyperphosphatemia therapeutic agent and/or preventi...
WO/2013/061285	IMPROVED PROCESS FOR PREPARING AN INTERMEDIATE OF THE MACROCYCLIC PROTEASE INHIBITOR TMC 435 The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS, 2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradeci ne-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-met ho...
WO/2013/060751	NOVEL PYRAZINE DERIVATIVES The invention relates to a compound of formula (I), wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
WO/2013/056915	MICROBIOCIDAL PYRAZOLE DERIVATIVES The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, G1, G2, G3, Y1, Y2, n, and p are as defined in the claims. The invention also relates to methods of using the compo...
WO/2013/058258	BICYCLIC HETEROCYCLIC COMPOUND [Problem] To provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11β-hydroxysteroid dehydrogenase type 1 contributes such as dementia, schizophrenia, depression, pain (particularly neu...
WO/2013/059222	2-PYRIDYLOXY-4-NITRILE OREXIN RECEPTOR ANTAGONISTS The present invention is directed to 2-pyridyloxy-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyl-oxy-4-nitrile compounds described herein in the treatment or...
WO/2013/057013	DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, composi...
WO/2013/056684	THIAZOLE DERIVATIVE AS DHODH INHIBITOR AND USE THEREOF The present invention relates to a thiazole derivative, as represented in formula I, as a DHODH inhibitor and a use thereof. The compound of the present invention can be used for treating or preventing DHODH-mediated diseases, including,...
WO/2013/059666	COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone...
WO/2013/057722	NEW SALT AND MEDICAL USE The invention provides 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2- fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof for the treatment of a disease associated with elevated blood ...
WO/2013/056679	NOVEL HETEROARYL-AMINO DERIVATIVES Disclosed is a compound of formula (I), wherein R1, R2, L, Rm and Rn are as defined herein. The compound of formula (I) may be used in preventing and/or treating acyl CoA-diacylglycerol acyltransferase 1(DGAT-1) related diseases, such as...
WO/2013/058256	NITROGENATED HETEROCYCLIC COMPOUND, AND BACTERICIDAL AGENT FOR AGRICULTURAL AND HORTICULTURAL PURPOSES Provided are: a nitrogenated heterocyclic compound represented by formula (1) or a salt or N-oxide compound thereof; and a bactericidal agent for agricultural and horticultural purposes, which comprises at least one component selected fr...
WO/2013/056911	MICROBIOCIDAL PYRAZOLE DERIVATIVES The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, G1, G2, G3, Y1, Y2, n, and p are as defined in the claims. The invention also relates to methods of using the compo...
WO/2013/055793	SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceut...
WO/2013/055895	APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Disclosed are compounds having Formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
WO/2013/055771	THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 Tdp1 inhibitors of Formula (I) and methods of using those inhibitors to treat cancer are provided in this disclosure. R1 is hydrogen or lower alkyl and G is a substituted phenyl or optionally substituted heteroaryl group. The disclosed T...
WO/2013/055949	PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulate...
WO/2013/053725	2-OXO-PIPERIDINYL DERIVATIVES The present invention relates to 2-oxo-piperidinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
WO/2013/055897	8 - CARBAMOYL - 2 - (2,3- DI SUBSTITUTED PYRID - 6 - YL) -1,2,3,4 -TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS - INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heter...
WO/2013/054291	NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereo...
WO/2013/054822	1 - ARYLCARBONYL - 4 - OXY - PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherei...
WO/2013/056015	ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and are useful in the treatment of diseases ...
WO/2013/055417	THIOPHENE BASED OLIGOMERS AS LIGHT ACTIVATED BIOCIDES Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their abilit...
WO/2013/050270	BENZOXAZINE DERIVATIVES AS CRAC MODULATORS Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calc...
WO/2013/052613	SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unreg...
WO/2013/050527	QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptab...
WO/2013/051769	MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME The present invention relates to a novel coumarin derivative, to a method for preparing same, and to a multi-fluorescent substance which includes the coumarin derivative and is able to emit light using an LED light source. According to t...

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