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Matches 1 - 50 out of 36,757

Document Document Title
WO/2018/189077A1
The invention relates to compounds of formula (I) which are suitable for controlling animal pests, which include arthropods and in particular insects, arachnids, and nematodes, and in which the structural elements R1, p, T, G and U have ...  
WO/2018/189554A1
Compounds having the general structure A - L - B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1 B. Pharmaceutical compositions comprising these compounds and meth...  
WO/2018/191283A1
Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.  
WO/2018/188785A1
The invention concerns a compound, wherein the compound is a substance according to the following formula (I) wherein the ring A is a pyrrolidine, piperidine, morpholine, or imidazole residue or a substituted pyrrolidine, piperidine, mor...  
WO/2018/189340A1
The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (...  
WO/2018/185526A1
What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent i...  
WO/2018/185266A1
The invention relates to compounds of formula: wherein R1 to R7 are as defined in the description. These compounds are useful as inhibitors of the YAP/TAZ-TEAD interaction.  
WO/2018/184115A1
Compounds comprising quinazolinone derivatives and methods of identification and use of imaging agents. The compounds have the general formula I: wherein R2 is selected from halogen, halosubstituted alkyl, alkyl, hydroxyl-alkyl, and amin...  
WO/2018/184392A1
The present invention provides formula I and formula II IDO inhibitors and preparation methods therefor, wherein R1, R2, and X groups are as defined in the specification. The present invention also provides a pharmaceutical composition c...  
WO/2018/185675A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, L and m are as defined herein, which are active as modulators of retinoid-related orphan recept...  
WO/2018/187553A1
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, L and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Fo...  
WO/2018/181883A1
The purpose of the present invention is to provide: a compound having anti-HBV activity or a salt thereof; a pharmaceutical composition; an anti-hepatitis B virus agent; a DNA generation inhibitor of a hepatitis B virus; and a hepatitis ...  
WO/2018/177865A1
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L1- Ar1- L - Ar]2- X, wherein X is selected from the group consisting of SO2, C1 -C4 a lkylene, linear or branched, and wherein Ζ...  
WO/2018/177854A1
The present invention relates to a polymorphic form of masitinib mesylate, processes for its preparation, pharmaceutical compositions comprising it and their medical use.  
WO/2018/178384A1
The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic h...  
WO/2018/181345A1
Provided is a compound which has an Nrf2-activating activity and is expected to be useful as a prophylactic or therapeutic agent for diseases associated with oxidative stress, particularly hepatitis (e.g., non-alcoholic steatohepatitis (...  
WO/2018/177995A1
The invention relates, inter alia, to compounds of general formula (I). The invention also relates to methods for synthesizing the compounds of formula (I). The compounds according to the invention are in particular suitable for controll...  
WO/2018/177781A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, (I). Th...  
WO/2018/178304A1
Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.  
WO/2018/183964A1
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1 -dependent disorders and enhancing an immune response. Also described are methods of inhibiting ...  
WO/2018/183411A1
Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxida...  
WO/2018/172480A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.  
WO/2018/172423A1
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compound...  
WO/2018/170664A1
Disclosed are oxazolidinone compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Disclosed herein also are compositions which comprise at least one oxazolidinone compound and...  
WO/2018/172250A1
The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprisi...  
WO/2018/174476A1
A compound represented by chemical formula 1, and an organic solar cell comprising the same are provided in the present specification. (I) In chemical formula 1: Ra and Rb are the same or different and are respectively and independently ...  
WO/2018/172477A1
The present invention relates to compounds of formula (I) wherein A1, A2, A3, A4, R1, R2, R3, R4 and n are as defined in claim 1; or a tautomer, isomer, enantiomer, salt or N-oxide thereof; to intermediates for preparing compounds of for...  
WO/2018/174288A1
To provide a useful novel compound exhibiting antimicrobial activity on the basis of inhibitory action of DNA gyrase GyrB and topoisomerase IV ParE. Provided is a 2(1h)-quinolinone derivative represented by formula (1), or a pharmaceutic...  
WO/2018/168714A1
Provided is an oxime ester compound represented by general formula (Iα) or (Iβ). (In the formulae: R1 to R6 and R101 to R108 each independently denote a group represented by general formula (II), a hydrogen atom, a halogen atom, a nitr...  
WO/2018/169092A1
There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellen...  
WO/2018/167001A1
The invention provides novel compounds having the general formula (I) wherein R1 is selected from substituted phenyl, pyridinyl or thiophenyl, R2 is selected from optionally substituted aminosulphonylphenyl, aminosulphonylpyridinyl, amin...  
WO/2018/166932A1
The present invention relates to arylamine derivatives which are substituted with diazanaphthalene groups, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according to th...  
WO/2018/166934A1
The present invention relates to dibenzofuran and dibenzothiophene derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compound...  
WO/2018/168818A1
The present invention relates to tetrahydroquinoline derivatives of the present invention or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them an...  
WO/2018/167269A1
The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatm...  
WO/2018/170165A1
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...  
WO/2018/169907A1
The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.  
WO/2018/170182A1
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...  
WO/2018/169038A1
A plant disease control agent which contains a compound represented by formula (1) as an active ingredient.  
WO/2018/164191A1
The present invention provides a substituted pyrrolidine compound having orexin receptor type 2 agonist activity. A compound represented by the formula (in the formula, each symbol is as described in the specification) or a salt thereof ...  
WO/2018/162364A1
The present invention refers to a process for a catalytic aryl transfer to rearrange the backbone of aromatic C-X bonds.  
WO/2018/162581A1
The present invention relates to desmethylanethole trithione ( AOX ) and derivatives thereof, especially derivatives of formula (I), for the prevention and treatment of diseases whose initiation and/or evolution relates to the production...  
WO/2018/163077A1
The invention relates to indanyl compounds, their pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising the same for the treatment, management and /or lessening severity of ...  
WO/2018/161876A1
The present invention relates to a dihydroquinoxaline bromodomain recognition protein inhibitor, a preparation method and a use thereof. The inhibitor of the present invention is a compound represented by general formula (I), or a stereo...  
WO/2018/165516A1
The invention relates to methods of treating cancer or myeloproliferative diseases with a combination of a glutaminase inhibitor and a second anticancer agent such as osimertinib, pazopanib, navitoclax, palbociclib, or olaparib. The inve...  
WO/2018/160022A1
The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure comprises a specific combination of a light-emitting layer and an electron transport zone, thereby pr...  
WO/2018/159835A1
The present invention provides a strigolactone receptor inhibitor for plants, which contains, as effective component, at least one triazole urea compound represented by formula (I); an agricultural composition; a method for using this ag...  
WO/2018/158210A1
The present invention is directed to pyridyl derivatives which are bromodomain inhibitors, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases or cond...  
WO/2018/158212A1
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases  
WO/2018/158365A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  

Matches 1 - 50 out of 36,757