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Matches 1 - 50 out of 37,595

Document Document Title
WO/2019/161010A1
The present invention relates to polycyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R4, R7 to R10, Y and A are as defined herein. The invention also relates to pharmaceutical compositions com...  
WO/2019/158607A1
The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic admini...  
WO/2019/156929A1
The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of using these compounds and compositions.  
WO/2019/156903A1
Disclosed are compounds of Formula 1, wherein J is and R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R14, R15, R16, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for c...  
WO/2019/133770A3
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the en...  
WO/2019/154663A1
The present invention relates to the use of compounds of formula I, wherein the variables are defined as given in the description and claims. The invention further relates to the compounds I and composition for compounds of formula I.  
WO/2019/153216A1
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), Ar is an aryl group, a heteroaryl group, or an aryl or heteroaryl group substituted by one or mo...  
WO/2019/154047A1
The present invention belongs to the field of pharmaceutical chemistry, and relates to an alkoxybenzo-five-membered (six-membered) heterocyclic amine compound as shown in formula I or a pharmaceutically acceptable salt thereof and the ph...  
WO/2019/155400A1
The present invention relates to new maleimides having general formula (I) and their use as herbicides.  
WO/2019/126253A8
Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmace...  
WO/2019/152536A1
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.  
WO/2019/150305A1
Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and compounds (I) for use as inhibitors of the KRAS protein for the tretament of cancer.  
WO/2019/151412A1
One embodiment of the present invention provides an ink set and application thereof. The ink set contains at least an ink containing a compound represented by general formula (Y-1) or (Y-2) and so forth; an ink containing general formula...  
WO/2019/149922A1
Present invention provides compounds that cause specifically the degradation of EGFR via the targeted ubiquitination of EGFR protein and subsequent proteasomal degradation. The present compounds are useful for the treatment of various ca...  
WO/2019/152527A1
The present disclosure relates to chemical compounds that modulate proteasome activity, pharmaceutical compositions containing such compounds, and use of these compounds and compositions for the treatment of disorders of uncontrolled cel...  
WO/2019/149260A1
The present invention relates to the field of pesticide technology, and specifically discloses a pyridazinol compound as represented by general formula I, a derivative thereof, a preparation method therefor, a herbicidal composition ther...  
WO/2019/145919A1
Present invention relates to compounds of formula (1) its enantiomers, diastereomers, racemic mixtures and their pharmaceutically acceptable salts. This invention also directed to antibacterial drug compounds that are capable of treating...  
WO/2019/144842A1
The present invention relates to a thiazole-5-formic acid derivative, a stereoisomer and a pharmaceutically acceptable salt thereof, the structure of the thiazole-5-formic acid derivative being represented by general formula (I). The com...  
WO/2019/148150A1
The present application provides bifunctional compounds of Formula X or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation ind...  
WO/2019/144765A1
Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin com...  
WO/2019/145726A1
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases an...  
WO/2019/144969A1
Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating d...  
WO/2019/146740A1
Provided is a novel compound which has D3 receptor antagonism. A compound represented by formula (I) (wherein: ring A represents a non-aromatic heterocycle, etc. substituted by an optionally substituted aromatic heterocyclic group, etc.;...  
WO/2019/144041A1
Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of ...  
WO/2019/141980A1
The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.  
WO/2019/143678A1
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various d...  
WO/2019/141027A1
The present invention provides a novel indoleamine 2,3-dioxygenase inhibitor, a preparation method thereof, and a pharmaceutical composition, in which the definitions of n, Y, Z, R1, R2, R3, and R4 are as stated in the specification. Als...  
WO/2019/141245A1
Provided are a crystal form of a tricyclic compound and a preparation method thereof. Also provided is an application of the crystal form in preparing a drug for treating a disease related to a sphingosine-1-phosphate subtype 1 (S1P1) re...  
WO/2019/142192A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin γ-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...  
WO/2019/136514A1
A novel class of inhibitors of protein kinases useful in the treatment of proliferative cell diseases and conditions including cancers, and especially those characterised by over-expression of CDK8 and/or one or more aberrant CDK8 activi...  
WO/2019/137985A1
The present invention relates to a novel class of tetrahydroisoquinoline compounds of formula I and to compositions comprising the same. The compounds and compositions of the present invention can be used as medicaments in the treatment ...  
WO/2019/132638A1
The present invention concerns the synthesis of a new class of polyheterocyclic molecules derived from thiazolylbenzimidazole containing the triazole unit, via a plurality of synthesis stages, and the use of these molecules in the field ...  
WO/2019/133445A1
The present disclosure provides compounds of formula (I) and pharmaceutically acceptable salts, solvates and salts of the solvates thereof, pharmaceutical compositions containing compounds of formula (I), as well as the use of compounds ...  
WO/2019/131582A1
Provided are a novel compound which is represented by general formula (1) and which has excellent agonistic activity on EP4 receptors, or a salt thereof, and a medicine that contains the compound or a salt thereof as an active ingredient...  
WO/2019/131922A1
The present invention provides a compound that has β2-adrenergic receptor antagonist activity and carbonic anhydrase-inhibitory activity, and that exhibits excellent ocular antihypertensive activity. Specifically provided is a compound ...  
WO/2019/132639A1
The present invention concerns a method for synthesising novel ionic liquids having antiproliferative activities on cancer cells, and the therapeutic applications of same as anticancer agents. A novel range of organic ionic liquids has b...  
WO/2019/126087A1
The present invention provides compounds of Formula (Ia) or (Ib):Formula (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds ...  
WO/2019/126103A1
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...  
WO/2019/126731A1
The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described ...  
WO/2019/122113A1
The present invention refers to new compounds useful in the treatment of leishmaniasis and, more particularly, to a series of 5-6-5 triazole-phenyl-thiazole heterocycles capable of inhibiting both activity and dimerization of L. infantum...  
WO/2019/121606A1
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glu...  
WO/2019/126094A1
The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA ...  
WO/2019/122418A1
The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma.  
WO/2019/126568A1
Nifuroxazide analogs, and their pharmaceutically acceptable salts and derivatives are described. Methods and uses are also provided that include the administration of an effective amount of the nifuroxazide analogs, or their pharmaceutic...  
WO/2019/121691A1
The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for...  
WO/2019/126253A1
Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmace...  
WO/2019/125849A1
The present invention provides for the treatment of disorders related to TLR7/8 overexpression or abherrant activation, wherein the disorder is selected from multiple sclerosis, Alzheimer's Disease, myositis, stroke, ischemia, CNS neurop...  
WO/2019/121661A1
The present invention relates to radiolabeled compounds of formula (I) wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.  
WO/2019/122320A1
The present disclosure relates to fungicidal active compounds, more specifically to heterocyclic benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, partic...  
WO/2019/122265A1
The present application relates to compounds of formula (I') or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerativ...  

Matches 1 - 50 out of 37,595