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Matches 1 - 50 out of 17,529

Document Document Title
WO/2018/188495A1
The present invention relates to a preparation method for a compound of Mod.I crystal form of 4-(4-chloroanilino)-7-(2-methylaminocarbonyl-4-oxomethyl)pyr idylfuro[2,3-d]pyridazine methanesulfonate (EOC315), crystal form characterization...  
WO/2018/187295A1
Near infrared and shortwave infrared dyes can have polymethine structures.  
WO/2018/177981A1
The invention relates to aromatic compounds which are suitable for synthesizing asymmetrical polydentate ligands. The invention further relates to a method for synthesizing asymmetrical polydentate ligands and metal complexes comprising ...  
WO/2018/176350A1
Disclosed in the present invention is a synthesis method for a spiro hydroxyindole cyclopentane β-intra-ester compound. Specifically, reactions are carried out by using phenyl-unsaturated aldehyde and unsaturated keto ester as reactants...  
WO/2018/181777A1
Provided is a compound which has tyrosine kinase inhibitory activity specific against C797S mutation-type resistant EGFR (particularly, C797S mutation-type tertiary resistant EGFR), and is useful as a C797S mutation-type resistant EGFR (...  
WO/2018/183964A1
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1 -dependent disorders and enhancing an immune response. Also described are methods of inhibiting ...  
WO/2018/182050A1
Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I) : wherein each symbol is as described in the DESCRIPTION, or a salt thereof may...  
WO/2018/178556A1
The invention relates to a crosslinking compound of formula (I). In particular, the present invention relates to a liquid composition comprising a monomer, a (meth)acrylic polymer and at least one crosslinking compound of formula (I). Th...  
WO/2018/182300A1
The present specification relates to a heterocyclic compound of chemical formula 1 and an organic light-emitting device comprising same.  
WO/2018/171684A1
Provided in the present invention are a class of 7H-azulene[1,2,3-i,j]isoquinolin-7-one compounds, a single crystal and a use thereof: a 7H-azulene[1,2,3-i,j]isoquinolin-7-one compound has a structure represented by formula (I), and the ...  
WO/2018/174681A1
The present specification relates to an organic light emitting element comprising a first electrode, a second electrode, and one or more organic material layers provided between the first electrode and the second electrode, wherein at le...  
WO/2018/171164A1
Provided is a camptothecin prodrug. The camptothecin prodrug is a prodrug formed by camptothecin or a derivative thereof and Evans blue, and the structural formula thereof is as shown in formula (I), wherein R1 is camptothecin or a deriv...  
WO/2018/174682A1
The present specification relates to a heterocyclic compound represented by chemical formula 1 and an organic light emitting element comprising the same.  
WO/2018/172984A1
This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed t...  
WO/2018/168232A1
[Problem] A problem was presented in that conventional photochromic compounds cannot be considered adequate in terms of the coloring/decoloring rate and durability, and the production process therefor has many steps. The present inventio...  
WO/2018/167606A1
A novel organic compound is provided. That is, a novel organic compound that is effective in improving reliability of a light-emitting element is provided. The organic compound includes a condensed ring including a pyrimidine ring and is...  
WO/2018/166932A1
The present invention relates to arylamine derivatives which are substituted with diazanaphthalene groups, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according to th...  
WO/2018/168818A1
The present invention relates to tetrahydroquinoline derivatives of the present invention or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them an...  
WO/2018/169260A1
The present invention provides: a compound capable of providing high light-emitting efficiency, low driving voltage, and improved lifespan of a device; an organic electronic element using the same; and an electronic device therefor.  
WO/2018/168292A1
The purpose of the present invention is to provide: an organic EL element material and a compound, each of which has high luminous efficiency; and an organic EL element, a display device and a lighting device, in each of which the organi...  
WO/2018/167269A1
The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatm...  
WO/2018/167690A1
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular t...  
WO/2018/164191A1
The present invention provides a substituted pyrrolidine compound having orexin receptor type 2 agonist activity. A compound represented by the formula (in the formula, each symbol is as described in the specification) or a salt thereof ...  
WO/2018/163216A1
The present invention provides a compound of general formulae I useful as GSK3β inhibitors and their anticancer potential and process for preparation of these spirooxindoles. Formula I wherein Z is hydrogen, halogen, hydroxy, alkoxy, cy...  
WO/2018/164192A1
The present invention provides a substituted pyrrolidine compound having orexin-2 receptor agonistic activity. A compound represented by formula (I) (wherein the symbols are as described in the description) or a salt thereof has orexin-2...  
WO/2018/165240A1
The present invention provides compounds useful as inhibitors of Tyrosine Kinase 2 (Tyk2), solid forms and compositions thereof, methods of producing the same, and methods of using the same in the treatment of Tyk2-mediated diseases.  
WO/2018/161876A1
The present invention relates to a dihydroquinoxaline bromodomain recognition protein inhibitor, a preparation method and a use thereof. The inhibitor of the present invention is a compound represented by general formula (I), or a stereo...  
WO/2018/162312A1
The present invention relates to novel spiro compounds of formula I, wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their ...  
WO/2018/158659A1
A novel organic compound. Specifically, a novel organic compound that is effective in improving element characteristics and reliability. An organic compound that has a condensed ring structure on a carbazole skeleton and is represented b...  
WO/2018/160022A1
The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure comprises a specific combination of a light-emitting layer and an electron transport zone, thereby pr...  
WO/2018/159964A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, it is possible to pro...  
WO/2018/157730A1
The present invention relates to a urea-substituted aromatic ring-linked dioxane-quinazoline compound of formula (1) and a urea-substituted aromatic ring-linked dioxane-quinoline, or a pharmaceutically acceptable salt thereof or a hydrat...  
WO/2018/159970A1
The present disclosure relates to an organic electroluminescent device comprising a light-emitting layer and a hole transport zone. By comprising a specific combination of a light-emitting layer and a hole transport zone, it is possible ...  
WO/2018/157232A1
Compositions comprising modulators of N-terminus activation of the androgen receptor, such as EPI-002 and EPI-506, and a second therapeutic agent are provided. Use of such compositions for treatment of various indications, including pros...  
WO/2018/159961A1
Disclosed are: a compound represented by chemical formula 1; an organic electric element comprising a first electrode, a second electrode, and an organic material layer between the first and second electrodes; and an electronic device co...  
WO/2018/154466A1
Compounds, specifically hepatitis B virus and/or hepatitis D virus inhibitors, more specifically compounds that inhibit HBe antigen and HBs antigen in a subject, for the treatment of viral infections, and methods of preparing and using s...  
WO/2018/153293A1
The present invention relates to dioxanoquinazoline of formula (I) and a dioxanoquinazoline-type compound or a pharmaceutically acceptable salt thereof. The present invention further provides a preparation method of the compound of formu...  
WO/2018/153380A1
The present invention relates to a preparation method for velpatasvir and a derivative thereof. Specifically, in the present invention, velpatasvir and the derivative thereof is prepared by means of an intermediate compound represented b...  
WO/2018/154501A1
The present invention relates to a compound of formula (I), wherein R1, R2, R3 and R4 are each independently hydrogen or Ra, with proviso that a pair of two substituents selected from R1 and R2, R2 and R3, and R3 and R4 is linked to one ...  
WO/2018/151479A2
The present specification relates to a heterocyclic compound represented by chemical formula 1 and an organic light emitting element comprising the same.  
WO/2018/151239A1
The present invention addresses the problem of providing an acid-sensing ion channel inhibitor which is orally administrable. The solution of the present invention is a compound represented by formula (I) or a pharmaceutically acceptable...  
WO/2018/149769A1
The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.  
WO/2018/151949A1
The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quan...  
WO/2018/146008A1
The present invention relates to compounds of general formula (I), wherein the groups R, R1, R2, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its...  
WO/2018/145216A1
An herbal pharmaceutical compositions of California poppy and methods for the treatment of sleep disorders and dream-related disorders is disclosed. The formulation may be in the form of capsules, tablets, caplets or other oral dosage fo...  
WO/2018/144605A1
The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.  
WO/2018/145021A1
The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compou...  
WO/2018/138039A1
The present invention relates to carbazole derivatives, particularly for use in electronic devices. The invention further relates to a method for producing the compounds according to the invention and to electronic devices comprising the...  
WO/2018/137610A1
A substituted 1-(isoxazole-3-yl)-3-(3-fluorine-4-phenyl)urea derivative, and a preparation method therefor and a use thereof, relating to the technical field of organic synthesis of medicines. A substituted 1-(isoxazole-3-yl)-3-(3-fluori...  
WO/2018/137639A1
The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method the...  

Matches 1 - 50 out of 17,529