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WO/2005/085269A1 |
A novel nucleotide derivatives showing a change in the fluorescent signal intensity depending on the relative base species in a partner chain in hybridization which occurs as a member of a single-stranded nucleotide sequence, such as: a ...
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WO/2005/082920A1 |
Described are crystalline forms of the pharmaceutical compound '[9S-(9&agr ,10ß,12&agr )]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-h
ydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',
1'-kl]pyrrolo[3,4-i][1,6]be...
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WO/2005/080351A1 |
The present invention related to a new N4-oxycarbonylcytidine derivative and its preparation. The present invention disclosed a new N4-oxycarbonylcytidine derivation represented by general formula (1), and provided the preparation of the...
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WO/2005/080404A1 |
A silyl linker that can be efficiently introduced in a solid-phase support for use in the synthesis of nucleic acid oligomers such as DNA. There is provided a silyl linker for solid-phase synthesis of nucleic acid, comprised of a compoun...
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WO/2005/079155A2 |
The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhi...
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WO/2005/077966A1 |
The present invention describes an improved hydroxyl protecting group of formula (1), wherein R2 and R7 are specified substituents and Q is O, S, NR10 or N(C=O)R10.
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WO/2005/070947A1 |
Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-2-methox
yadenine, then deprotection of the 9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl...
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WO/2005/070946A1 |
A novel ribonucleic acid compound in a phosphoric triester form. It is important for the liquid-phase synthesis of an oligo RNA. It is a ribonucleic acid compound represented by the following general formula. In the formula, B represents...
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WO/2005/070859A1 |
The invention provides supports which enable mass production of biopolymers such as nucleic acids and can be reutilized at need, namely, fluorous supports represented by the general formula (1a): wherein R1, R2 and R3 are each independen...
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WO/2005/067644A2 |
Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residus of 6-aminohexanoic acid and optionally 7-10 residus of polyethyleneglycol (PEG). The l...
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WO/2005/067960A1 |
Provided are synthetic peptides based on a native sequence of HIV gp41 HR2 except that the synthetic peptides have a plurality of amino acid replacements comprising (a) a helix-promoting amino acid, or (b) a combination of helix-promotin...
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WO/2005/063786A2 |
The present invention provides a process for producing a N4-acyl-5'-deoxy-5-fluorocytidine compound of the formula (I), where R2 is alkyl, cycloalkyl, aralkyl, aryl, or alkoxy.
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WO/2005/063787A2 |
The present teachings relate to nucleobase, nucleoside and nucleotide compounds, methods of synthesis, and uses thereof. The present teachings provide compounds, such as nucleobase, nucleoside and/or nucleotide compounds including a prop...
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WO/2005/063788A1 |
The invention provides benzimidazole derivatives represented by the general formula (I) or pharmacologically acceptable salts or prodrugs thereof which exhibit inhibitory activities against sodium-dependent nucleoside transporter 2 and a...
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WO/2005/058228A2 |
Objects of the present invention are the compounds of formula (I) wherein Rl is H, CN, halogen, COR2; -S(O)xR2, C1-12-alkyl, C2-12-alkenyl, C3-8-cycloalkyl, a heterocyclyl group, an aryl group, a heteroaryl group, C3-8-cycloalkyl(C1-3)al...
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WO/2005/058246A2 |
The invention is a novel method and precursor for preparing radiolabeled nucleosides. In particular, the invention is useful for preparing 3'-[18F]fluorothymidine. The method uses an enol group that is attached to the 2-position on the p...
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WO/2005/059157A2 |
Methods and compositions for producing hRNA, e.g., shRNA, expression modules for specific target nucleic acids are provided. In the subject methods, an initial nucleic acid, e.g., dsDNA, synthetic DNA, etc., corresponding to the target n...
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WO/2005/059097A2 |
This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This inve...
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WO/2005/058247A2 |
The invention is a method and related precursor for preparing 18F-FLT. The precursor has a butoxycarbonyl protecting group at the 5'-position that results in low amounts of chromophoric byproducts being formed during deprotection. The me...
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WO/2005/056571A1 |
Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R = C1-6 alkoxy (straight or branched), a phenoxy group (unsub...
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WO/2005/054268A1 |
Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
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WO/2005/054269A1 |
A method of synthesis of a 2-substituted adenosine of formula I which comprises converting a compound of formula II to a compound of formula (I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-...
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WO2005021568B1 |
Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
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WO/2005/049633A1 |
The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is fu...
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WO/2005/044836A2 |
The invention relates to novel classes of nucleotides that can be used as substrates for enzymes, e.g. for labeling nucleic acids.
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WO/2005/044835A1 |
Disclosed are methods and intermediates for the preparation of 7-(2'-R1-substituted-ß-D-ribofuranosyl)-4-amino-5-(optional
ly substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infec...
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WO/2005/044312A1 |
The present invention is directed to novel chemical agents for compounds and their use for imaging myocardial perfusion. The invention also is directed to a kit for forming such novel agents. The chemical agents for the present invention...
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WO/2005/042557A1 |
A method for producing a purine compound represented by the following formula (3): (3) (wherein X, Y, R2, R3 and R4 are as defined below) is disclosed which includes a step wherein purines represented by the following formula (1): (1) (w...
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WO/2005/042556A1 |
Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
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WO/2005/040184A1 |
A process is described for the preparation of doxifluridine of formula (I) at high yields and with reduced formation of impurities, which comprises the reaction of coupling of a compound of formula (III) with a compound of formula (IV), ...
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WO/2005/039484A2 |
The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of general Formulas (I) and (II) that inhibit topoisomerase I activity.
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WO/2005/040183A2 |
A description is given of a process for the preparation of 9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate starting from 9-beta-D-arabinofuranosyl-2-fluoroadenine by reaction with a mixture composed of triethyl phosphate and phosp...
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WO/2005/040185A1 |
A method for producing a compound represented by the general formula (2) below is characterized in that a compound represented by the general formula (3) below is added when the compound represented by the general formula (1) below is re...
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WO/2005/035545A2 |
Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
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WO/2005/034943A1 |
The present invention provides novel chemical compounds and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivati...
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WO/2005/033121A2 |
Disclosed herein is a process for making aralkoxy- or alkoxyadenosines wherein a sugar protected haloadenosineis synthesized and the intermediate product is alkoxylated and then deprotected.
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WO/2005/030997A1 |
The methods and apparatus disclosed herein concern nucleic acid characterization by enhanced Raman spectroscopy. In certain embodiments of the invention, exonuclease treatment of the nucleic acids results in the release of nucleotides. T...
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WO/2005/028489A2 |
The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5’ position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives ...
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WO/2005/027838A2 |
Methods and compositions are provided for efficiently preparing and manufacturing pentostatin. Also provided are novel precursors of pentostatin, pentostatin analogs and derivatives. In one aspect of the invention, a method is provided f...
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WO/2005/028481A2 |
Disclosed are polycyclic polyether compounds of formula: (I) and pharmaceutical compositions comprising such compounds. Wherein R, OR1 and R2 are as defined herein. Also disclosed are methods of regulating mucus clearance in a cell, and ...
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WO/2005/028494A1 |
A process in which nucleotide monomer synthesis and chain extension utilizing the synthesis can be easily conducted and problems in the H-phosphonate method are overcome. The process comprises reacting a nucleoside (2) with a phosphityla...
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WO/2005/027962A2 |
The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least o...
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WO/2005/026186A1 |
The invention relates to nucleoside analogues, nucleic acids and pharmaceutical agents comprising these, and to the use of the nucleoside analogues, nucleic acids and pharmaceutical agents for diagnosing, preventing or treating a viral, ...
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WO/2005/026318A2 |
The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine rec...
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WO/2005/026187A1 |
A nucleoside, nucleotide, or derivative of either which has a nonnatural base. It is characterized by having as a base a 2-amino-6-(2-thiazolyl)purin-9-yl or 2-amino-6-(2-oxazolyl)purin-9-yl group (wherein the thiazolyl or oxazolyl group...
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WO/2005/026188A1 |
A double-stranded oligonucleotide derivative which contains two oligonucleotide derivatives including at least one nucleotide derivative having been substituted at a nucleotide base part by a metal coordination group being hardly oxidize...
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WO/2005/023826A2 |
The present invention relates to the polymorphic crystalline hydrochloride salts of a nucleoside valinate ester according to formula Ib, methods of treating diseases mediated by Hepatitis C Virus and pharmaceutical composition containing...
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WO/2005/023829A1 |
It is intended to provide a novel structure in which metal atoms can be one-dimensionally aligned and which can exist in a stable state. Namely, a double-stranded oligonucleotide derivative which contains two oligonucleotide derivatives ...
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WO/2005/023827A1 |
Process and novel intermediates for preparing 2-aminocarboxylic acid esters of the 5- hydroxymethyl group of levovirin (1-(3S, 4R-dihydroxy-5S-hydroxymethyl-tetrahydro furan-2S-yl)-IH-[1,2,4]triazole-3-carboxylic acid amide; Id: R1=R2 ...
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WO/2005/021571A1 |
Disclosed is a method for producing a compound represented by the general formula (5) below wherein a compound represented by the general formula (1) below or a salt thereof is reacted with a dimethoxytrityl halide for isolating a compou...
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