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WO/2002/076400A2 |
Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an infammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in nee...
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WO/2002/074781A1 |
An improved process for preparing N6-substituted aminopurine ribofuranose nucleosides. Compounds of this type are known to be useful in the preparation of compounds having activity at adenosine receptors, e.g. Adenosine A1 receptor. The ...
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WO/2002/074911A2 |
A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the steps of: (a) obtaining a sample of nucleic acid isolated form the organism's organ, tissue or cell, wherein the nucleic acid is RN...
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WO/2002/074780A1 |
The present invention is concerned with pharmaceutical compositions containing certain adenosine derivatives having an acetylene group in the 4' position, which are adenosine A1 agonists, and to their use in therapy.
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WO/2002/074910A2 |
The present invention relates to dideoxynucleoside analog compounds containing a dideoxy ribofuranosyl moiety that exhibit selective anti-viral activity coupled with substantially low toxicity toward the host cells. In particular, the co...
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WO/2002/073201A1 |
It is intended to provide reagents for labeling a protein which makes it possible to introduce one molecule of a labeling and one molecule of an affinity substance or a covalent bond-forming reactive group per molecule of a target protei...
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WO/2002/072595A2 |
The invention relates to an improved method for the production of pentopyranosyl nucleosides, in which a significant improvement and simplification of the method steps described in DE-A-19741715 can be achieved. According to the inventio...
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WO/2002/072869A2 |
Novel agents acting as co-factors for replacement of NAD(P)?+¿/NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P)?+¿/NAD(P)H system in enzymatic oxidation/reduction of substrates int...
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WO/2002/072791A2 |
A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar rea...
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WO/2002/072779A2 |
Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a ...
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WO/2002/070534A1 |
The present invention pertains to novel C2,8-disubstituted adenosine derivatives, which are found to be potent adenosine receptor agonist, particularly for the A2A receptor. Further provided by the invention is a process for the preparat...
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WO/2002/070532A2 |
The present invention concerns novel C2,5'-disubstituted and N?6¿',C2,5'-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adenosine receptor agonists and thus are of a th...
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WO/2002/069982A1 |
The present invention relates to the use of adenosine A1 agonists having an agonist action at adenosine A1 receptors in the treatment of emesis.
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WO/2002/069903A2 |
The compounds represented by the formulae (I) wherein X is selected from the group consisting of: O, S, N-R?1¿, and CHR?1¿; Y and Y' is individually selected from H, OR?1¿, NR?1¿R?2¿, and N¿3? Z and Z' is individually selected from...
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WO/2002/070533A2 |
The present invention is an efficient synthetic route to 2',3'-dideoxy-2',3'-didehydro-nucleosides from available precursors with the option of introducing functionality as needed, such as, the 2',3'-dideoxy and 2'- or 3'-deoxyribo-nucle...
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WO/2002/068443A1 |
The present invention relates to the preparation of (E)-5-(2-bromovynyl)-2'-deoxyuridine (Brivudine) characterized in that halogen-free solvents selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2'-deoxyur...
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WO/2002/068442A1 |
A compound of formula wherein X?-¿ is an anion; n is 1, 2, 3 or 4; R¿1? is C¿1?-C¿12?alkyl, C¿3?-C¿8?cycloalkyl; or C¿2?-C¿12?alkenyl; R¿2? is hydrogen, unsubstituted or substituted C¿1?-C¿12?alkyl or C¿2?-C¿12?alkenyl; R¿3...
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WO2001049687A9 |
Replacement of the furanose moiety of, for example, DNA by a cyclohexene ring gives a new nucleic acid structure: cyclohexene nucleic acids or CeNA. Cyclohexene nucleic acids can be obtained by the classical phosphoramidite chemistry sta...
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WO/2002/068537A2 |
The invention relates to fluorescent dyes. More particularly, the invention relates to fluorescent cyanine dyes, and especially to water soluble fluorescent cyanine dyes that contain additional sites for attachment to biomolecules. The i...
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WO/2002/067951A2 |
The invention relates to the use of 5-substituted nucleosides and/or prodrugs thereof together with at least one active substance in order to produce a medicament or combination preparation used in the resistance-free treatment of infect...
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WO/2002/068441A2 |
What is described are a compound of formula (I) in which, R¿1? is C¿1?-C¿12?alkyl, C¿3?-C¿8?cycloalkyl or C¿2?-C¿12?alkenyl; R¿2? is H, unsubstituted or mono- to pentasubstituted C¿1?-C¿12?alkyl or unsubstituted or mono-to pent...
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WO2001010882A9 |
The present invention is directed to novel compounds exhibiting a selective inhibition of the reproduction of HIV and HBV and possessing low toxicity. The present compounds are VI-VIII of formulae (VI, VII and VIII) wherein: Nucleosides ...
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WO/2002/066020A2 |
The present invention concerns the modulation of glycogene synthase kinase 3$g(b) (GSK-3$g(b)) by an adenosine receptor ligand. Depending on the type of ligand, the modulation may be manifested by down-regulation or up-regulation of the ...
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WO/2002/064609A1 |
Crystals of a pyrimidine nucleoside derivative having excellent antitumor activity. They are crystals of the compound represented by the following formula (I).
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WO2000006771A9 |
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivati...
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WO/2002/062815A1 |
The invention relates to photo-labile hybrid protecting groups and the application thereof in the synthesis of protected synthons for the light-controlled synthesis of biopolymers, in particular nucleic acids.
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WO2002016381B1 |
This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject...
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WO/2002/062816A1 |
Nucleotide derivatives of formula (1) are described: wherein: G is a hydrogen atom or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, polycycloaliphatic, aromatic or heteroaromatic group or a non-natural nucleoside ...
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WO/2002/062747A1 |
The invention relates to photolabile protective groups for the synthesis of biopolymers, particularly nucleic acids.
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WO/2002/062811A2 |
The present invention is directed to improved methods and compositions for synthesis of oligonucleotides and other phosphorus-linked oligomers, without the need for phosphoryl protecting groups. The methods involve the reaction of nucleo...
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WO/2002/062123A2 |
The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome...
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WO/2002/062814A1 |
The subject invention provides compounds and methods of producing compounds, which are useful inhibitors of glycosyltransferase enzymes. These compounds represent a new class of glycosyltransferase inhibitors and are potent inhibitors of...
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WO2001028545A9 |
Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring genetically encoded molecules in mammals. M...
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WO/2002/060913A1 |
The invention relates to compounds, which are suitable for use as labelling precursor substances for producing 3'-[?18¿F]-fluoro-3'-deoxy thymidine and are structured as per formula (1). In said formula, R represents triphenylmethyl, tr...
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WO/2002/058740A1 |
Drugs containing as the active ingredient radioactively labeled compounds of the following general formula or pharmaceutically acceptable salts thereof: [wherein R¿1? is hydrogen or linear or branched C¿1-8? alkyl; R¿2? is hydrogen, h...
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WO/2002/059084A2 |
The present invention provides pharmaceutical compositions for inhibiting and treating diseases associated with ADP−ribosyl transferase, ADP−ribosyl cyclase, or ADP−ribosyl hydrolase.
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WO/2002/057287A2 |
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the ...
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WO/2002/057425A2 |
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA...
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WO/2002/057288A1 |
The present invention relates to an acyclic nucleoside phosphonate derivative, which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the prepa...
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WO2002021098B1 |
The present invention relates to methods for the detection of polymorphism in polynucleotides by using hybridization of fragments of segments of a polynucleotide suspected of containing a polymorphism with an oligonucleotide having a seq...
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WO2001005837A9 |
The invention provides a method for assaying compounds that affect smooth muscle cell function by determining the interaction between a cyclic GMP-dependent protein kinase, and a myosin phosphatase myosin-binding subunit.
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WO2000061816A9 |
A method of improving amplification of nucleic acids using a nucleic acid sequence-based amplification ("NASBA") method is provided wherein target nucleic acids and NASBA primers are electronically addressed to electronically addressable...
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WO2002015904B1 |
A method of delivering a drug to a hepatocyte includes a step in which a carboxamidine group-containing compound is provided to a hepatocyte having a transporter that transports the compound across the plasma membrane of the hepatocyte, ...
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WO/2002/051425A1 |
Excellent remedies for hepatitis C which contain as the active ingredients a 3'-deoxy-3'-fluorouridine derivative and a 1-(3'-deoxy-3'-fluoro-$g(b)-L-ribofuranosyl)uracil derivative and show little side effects.
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WO/2002/048166A1 |
The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of following general formulas (I) and (II) that inhibit topoisomerase I activity.
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WO/2002/048331A2 |
The present invention provides mutant nucleotidylyltransferases, such as E¿p?, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyltransferases...
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WO/2002/048165A2 |
The disclosed invention is a composition for and a method of treating Flaviviridae (Hepacivirus, Flavivirus, Pestivirus) infections, including BVDV and HCV, and abnormal cellular proliferation in a host, including animals, and especially...
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WO/2002/044196A1 |
Methods for synthesizing RNA molecules whose 5'-terminus comprises a thiol group are disclosed. The present invention discloses the formation of 5'-HS-PEG-GMP-RNA and 5'-GMPS-RNA which upon alkaline phosphate treatment, independently lea...
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WO/2002/044416A2 |
Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., autom...
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WO/2002/044194A1 |
A novel process for preparing 2,2'-anhydro-1-(ß-L- arabinofuranosyl)thymine which is novel and a useful intermediate; a novel process for preparing L-thymidine from 2,2'-anhydro-1-(ß-L-arabinofuranosyl)thymine; and a novel process for ...
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