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WO/2001/096357A2 |
This invention pertains to solid-phase oligosynthesis, and more particularly to universal solid supports for solid-phase oligonucleotide synthesis, methods for their preparation, and methods for their use. One aspect of the invention per...
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WO/2001/096609A1 |
A simple, nondestructive, and high throughput method for establishing DNA binding affinity and sequence selectivity is based on the loss of fluorescence derived from the displacement of ethidium bromide or thiazole orange from the DNA of...
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WO/2001/096354A1 |
The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. ...
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WO/2001/093903A1 |
The invention relates to a composition comprising: a T cell epitope or a mixture of T cell epitopes, a polycationic peptide and a nucleic acid based on inosin and cytosin and its use as a vaccine.
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WO2000030656A9 |
The present invention is directed to compositions comprising 1-( beta -D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provid...
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WO/2001/093873A1 |
A method for prophylaxis or treatment of obesity that includes providing a patient, particularly a human patient, suffering from or believed to be at risk of suffering from obesity and administering intermittently to the patient a therap...
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WO/2001/094368A1 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses...
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WO/2001/093905A1 |
Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I), wherein any NMP is a 2' deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deox...
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WO/2001/094609A1 |
The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting...
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WO/2001/092282A2 |
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1', 2' or 3'-modified nucleoside or a pharmaceutically acc...
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WO/2001/091737A2 |
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described 2'-deoxy-$g(b)-L-erythropentofuranonucleoside or a pharmaceutically acceptable salt ...
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WO/2001/092284A1 |
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W ...
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WO/2001/090130A1 |
The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS, RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower t...
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WO/2001/090121A2 |
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1', 2' or 3'-modified nucleoside or a pharmaceutically acceptable salt or prodrug th...
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WO/2001/087235A2 |
A method for producing [?18¿F] fluoride ion comprises loading an enclosed chamber (16) of a metal target with [?18¿O]oxygen gas. The [?18¿O] oxygen gas is irradiated in the enclosed chamber (16) to produce [?18¿F] fluoride ion in the...
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WO/2001/085165A2 |
The invention relates to the use of lipoic acid and C¿1? donors, especially S-adenosylmethionine and/or 5-methyltetrahydrofolate, for treating disorders of the central nervous system. The invention also relates to agents containing a co...
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WO/2001/085749A1 |
A compound, which can show potent anti-viral activity against, for example, cytomegalo virus, has the formula (I), wherein R is selected from the group comprising, optionally substituted, C¿5? to C¿20? alkyl and, optionally substituted...
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WO/2001/085751A1 |
Disclosed are polymeric compounds which are useful as prodrugs, comprising a chain of monomeric nucleosides, nucleoside analogs or abasic nucleosides, wherein at least one of the nucleosides or nucleoside analogs or a heterocyclic deriva...
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WO/2001/085750A1 |
The invention concerns compounds of formula (I) wherein: R¿2? is hydrogen, halogen, alkyl, alkenyl or alkynyl, a OH, O-alkyl, OCO-alkyl radical, an O-aryl or OCO-aryl radical; R¿4? is CH¿2?NH¿2?; CH¿2?NHalkyl, CH¿2?N (alkyl1) (alky...
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WO/2001/083502A1 |
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound and separation and detection. For oligonu...
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WO/2001/082965A1 |
Therapeutically effective anti-microbial compositions, useful especially against respiratory diseases caused or mediated by viruses, bacteria, and other respiratory parasites are disclosed, wherein said compositions comprise at least one...
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WO/2001/083501A1 |
The invention pertains for a compound having the formula (I) wherein W, U', U'', Q, Z, X, R¿8?, R¿9? and Ar are as defined in the description. The compounds may be used to treat viral infections.
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WO/2001/084234A1 |
This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as t...
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WO2000066607A9 |
Methods and compositions are provided for detecting DNA sequences, particularly single nucleotide polymorphisms, using a pair of nucleotide sequences, a primer and a snp detection sequence, where the snp detection sequence binds downstre...
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WO/2001/083500A1 |
Compounds of formula (I) and salts thereof, wherein: R?1¿ represents methyl, ethyl, isopropyl or s-butyl; R?2¿ represents hydrogen or alkyl; R?3¿ represents hydrogen, optionally substituted alkanoyl, optionally substituted alkenoyl, o...
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WO/2001/081360A1 |
The invention relates to novel, photo-labile cumarinylmethyl esters of cyclic nucleotides of general formula (I): axial isomer (Ia), equatorial isomer (Ib); wherein R?1¿ represents hydrogen, bromine or p-chlorophenylthio, R?4¿ represen...
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WO/2001/081359A1 |
Ribavirin derivatives represented by the formula (II), pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula (II) for the preparation of a medicament for the treatment of s...
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WO2001060381B1 |
Novel nucleoside analog compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestati...
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WO2000040605A9 |
The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least...
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WO2000053812A9 |
Disclosed are improved methods of making and using immobilized arrays of nucleic acids, particularly methods for producing replicas of such arrays. Included are methods for producing high density arrays of nucleic acids and replicas of s...
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WO/2001/078749A1 |
Novel calcium antagonists containing as the active ingredient nucleoside 5'-alkylphosphate compounds represented by the following general formula: wherein R represents a liner or branched alkyl; and B represents a base constituting a nuc...
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WO/2001/079248A1 |
An efficient process for the preparation of cytidine derivatives in which efficient synthesis of cytidine derivatives is attained by using a tertiary amine to thereby overcome the disadvantages of the prior art.
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WO/2001/079246A2 |
The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a proliferative disorder in a patient using an effecti...
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WO/2001/077103A1 |
The present invention relates to a process for preparing 5'-acetylstavudine, an intermediate which is useful in the preparation of 2',3'-didehydro-3'-deoxythymidine, an active principle with antiviral action which is commonly known as st...
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WO/2001/077075A2 |
The invention provides a novel class of substituted isoindolinone derivatives. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, prodrugs, or mixtures thereof are ...
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WO/2001/077083A1 |
The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.
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WO/2001/075139A1 |
The present invention relates to improved alternatives for hot-start PCR hybridization and amplification methods by using, in an embodiment, a heat-reversible, covalent modification of nucleic acids to disrupt hybridization of primer to ...
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WO/2001/074827A1 |
Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs ...
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WO/2001/073095A2 |
Methods for preparing various different deoxynucleosides from their corresponding ribonucleosides are disclosed which proceed via thiocarbonyl intermediates, which intermediates are subjected to one or more free-radical-initiated deoxyge...
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WO/2001/072294A2 |
A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog or a prodrug or pharmaceutically acceptable salt thereof that suppresses the expre...
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WO/2001/073110A1 |
The present invention discloses the use of quaternary compounds as stabilizing agents for highly-sensitive fluorescent nucleic acid stains in aqueous solvents, their use in gels to give increased usable shelf life, and in compositions of...
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WO/2001/072288A2 |
The invention relates to the use of CDP-Choline or its pharmaceutically acceptable salts for the preparation of a medicinal product for the treatment of alcohol withdrawal syndrome at daily doses equivalent to 0.5-2g of free CDP-Choline.
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WO/2001/072764A1 |
The present invention is directed to a nucleic acid binding compound comprising N?8¿- or C?8¿-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this n...
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WO/2001/068064A2 |
The invention describes the prophylactic treatment of cerebral ischemia with CDP-Choline in patients who have undergone major surgery or are at risk of suffering an acute ischemic event.
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WO/2001/068673A1 |
The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogu...
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WO/2001/068867A1 |
The complete sequence of the gene cluster for the monensin type I polyketide synthase, from S. cinnamonensis, is provided. Thus variant polyketides containing monensin-derived elements can be genetically engineered. Furthermore there are...
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WO/2001/066118A1 |
4'-Thio-L-Xylo furanosyl nucleosides can be used as anti-cancer agents, or antiviral agents or to inhibit DNA replication.
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WO/2001/066556A1 |
Nucleic acids having a novel base whereby nucleic acids can be reversibly ligated to each other by light-irradiation; nucleic acids wherein these nucleic acids have been immobilized; a method of conveniently producing branched nucleic ac...
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WO/2001/064958A2 |
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
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WO/2001/064706A1 |
Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids enc...
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