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WO/1996/034609A1 |
Systematic chemical analysis of glycosphingolipid (GSL) fractions from large quantities of normal human neutrophils and HL60 cells failed to detect GSL's which are binding targets of selectin. A series of long-chain, unbranched polylacto...
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WO/1996/034005A1 |
The present invention provides a process for synthesizing a compound having structure (I), wherein R is H, as well as related oligosaccharides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therap...
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WO/1996/034004A1 |
The invention provides a novel endo-type fucoidan hydrolase and a novel microorganism useful for producing sugar compounds. The sugar compounds refer to the compounds represented by general formula (1), wherein at least one alcoholic hyd...
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WO/1996/033726A1 |
Sulfated oligosaccharides, wherein the oligosaccharide has the general formula (I): R1-(Rx)n-R2, wherein R1 and R2 and each Rx represents a monosaccharide unit, all of which may be the same or different, adjacent monosaccharide units bei...
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WO/1996/031219A1 |
The primary etiology of antibiotic-associated diarrhea (also known as pseudomembranous colitis) has been recognized as Clostridium difficile. It is believed that the indigenous microflora of a healthy individual suppresses the normally p...
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WO/1996/026965A1 |
The present invention is directed to a new process for the production of chitin oligomers, including fragmentation, partial hydrolysis and recovery. This process produces high yields, especially of higher (tetra- to deca-) chitin oligomers.
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WO/1996/023479A2 |
The invention concerns the use of a compound or a number of compounds from the group of the carbohydrates or carbohydrate derivatives as anti-adhesive active principles directed against micro-organisms, parasites and protozoa.
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WO/1996/019988A1 |
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhib...
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WO/1996/017824A2 |
Compounds and methods are provided for use in monosaccharide analysis. The present invention discloses hydrazino monosaccharide derivatives. Methods for preparing and using hydrazino monosaccharide derivatives for structural analysis of ...
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WO/1996/014124A1 |
A method of processing a cheese processing waste stream generated in a cheese-making process is described.
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WO/1996/009309A1 |
A specific ligand for E- and P-selectin was isolated from in vivo[3H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E- or P-selectin rIg-agarose chromatography. The total O-linked oligosaccharides o...
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WO/1996/008257A1 |
Compositions of matter comprising glycosphingolipids useful for suppressing an immune response having formula (I) wherein x is (a) or (b) or H; wherein Y is (c) or H; wherein m is 10 to 20; and wherein n is 1 to 14. Also presented are me...
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WO/1996/006102A1 |
The present invention relates to oligosaccharide mixtures whose individual constituents have an identical core structure which is substituted by at least one sugar and in which all positional isomers are represented, and all isomers with...
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WO/1996/006103A2 |
'alpha'-D-pentofuranoside derivatives have the general formula (D), in which R stands for a (C1-C4)alkyl that is non-substituted or substituted one or several times by halogen, (C1-C4)alkyl, (C1-C4)alkoxy and/or phenyl, and R1 stands for...
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WO/1996/005209A2 |
Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fu...
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WO/1996/003413A2 |
Inter alia, a direct method for the regioselective sulfation of an organic molecule having optionally derivatized hydroxyl groups at least on two adjacent carbon atoms characterised in that it comprises the treatment of a di-(optionally ...
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WO/1996/003418A1 |
The present invention relates to novel soluble combinatorial libraries, comprising a soluble phase in solution attached to a core molecule, and allowing the improved high-yield and efficient production of soluble combinatorial libraries....
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WO/1996/002255A1 |
A medicinal composition containing a sialic acid derivative as the active ingredient and usable as an antiviral agent, diarrhea remedy, antiulcer agent, antiinflammatory agent, antiallergic agent and bifidus growth accelerator. A process...
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WO/1996/002550A1 |
The invention describes 7-O-carbamoyl heptose derivatives of general formula (I) in which R is the substituent R1 or a group of general formula (II) in which R1 is a hydrogen atom, a methyl group or a suitable linker substituent suitable...
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WO/1996/000229A1 |
Compounds including one or more oligosaccharides each of which is covalently bonded to one or more, particularly one, two or three, molecules, matrices or particles, by means of an intermediate molecule having a nitrogen atom on an 'alph...
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WO/1995/034570A1 |
A process for producing a disaccharide by conducting the condensation reaction of 'beta'-glucose-1-phosphate with a monosaccharide in an aqueous medium in the presence of an enzyme source originating in a microorganism of the genus Catte...
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WO/1995/034673A1 |
The invention relates to a process for producing polyvalent polymer-based carbohydrate receptor blockers which in vivo do not, either in their complete form or when broken down, provoke intolerance reactions. The carbohydrate side chain ...
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WO/1995/029927A2 |
Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten...
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WO/1995/025113A1 |
The present invention provides a compound having structure (I), wherein A is selected from the group consisting of (i) an amino acid bearing an 'omega'-amino group or an 'omega'-(C=O)- group, (ii) an amino acid residue of a peptide, whic...
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WO/1995/024437A1 |
The present invention concerns polymer-based polyvalent malonic acid derivatives having anti-adhesive properties and consisting of a polyamino acid which is linked in each case by a spacer of formula (I) -[-Q1-CH2)p-Q2-]r-, in which Q1 m...
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WO/1995/024495A1 |
The invention relates to the milk of a transgenic non-human mammal. The milk is characterized in that it contains heterologous components produced as the secondary gene products of a heterologous gene contained in the genome of the trans...
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WO/1995/023156A1 |
A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3...
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WO/1995/021850A1 |
Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is responsible for the activity can be isolated by f...
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WO/1995/021180A1 |
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In said formula eac...
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WO/1995/018971A1 |
An efficient and versatile method of forming N-linked glycoconjugates is described wherein a glycosyl acceptor, typically comprising an activated carboxyl group, is reacted with a glycosylating agent, typically a glycosylamine, in the pr...
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WO/1995/018864A1 |
Disclosed is a method of producing a compound with 'beta'1-4 linkage which contains the lactosamine structure involving reacting at least one donor substance Gal'beta'OR where R is an organic group, and at least one acceptor substance wh...
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WO/1995/018814A2 |
A method for the synthesis of oligosaccharides on a polymer support that allows to perform glycosylation steps in solution whereas the products are isolated by precipitation with an anhydrous ether and purified by crystallization from an...
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WO/1995/016049A1 |
A stereoselective synthesis of carbohydrates employs two key stereoselective steps, viz. an osmium-catalyzed asymmetric dihydroxylation (AD) of an alkene to form an aldol intermediate and an aldolase-catalyzed aldol addition reaction whe...
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WO/1995/013819A1 |
Sulfated oligosaccharides which bind to L-selectin receptors and act as agonists are formulated into pharmaceutical formulations and administered by injection to treat inflammation. Compounds which act as metabolic inhibitors of carbohyd...
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WO/1995/010616A2 |
A method of preparing the sugar 1,5-D-anhydrofructose is described. The method comprises treating an 'alpha'-1,4-glucan with an 'alpha'-1,4-glucan lyase wherein the enzyme is used in substantially pure form. In a preferred embodiment, if...
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WO/1995/009861A1 |
A method for obtaining lactulose crystals from an aqueous lactulose solution in the form of a syrup containing other sugars, wherein (a) an amount of ethanol is added to said syrup to give a mixture in which the mass of water forms 1.27-...
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WO/1995/009243A1 |
The method for producing crystalline 'alpha','alpha'-trehalose by isolation from baker's yeast consists in the extraction of baker's yeast with ethanol of concentration 70 to 96 volume %, vacuum concentration of the obtained extract to t...
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WO/1995/008553A1 |
The total synthesis of the naturally occurring sulfated Lex and Lea tetrasaccharides, trisaccharide analogs of sulfated Lex and Lea, and multivalent Lex selectin ligands are described.
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WO/1995/007997A1 |
The present invention relates to new Bacillus sp. SY-414 that produced antifungal antibiotic, trihexocin, which was produced by the above Bacillus sp. SY-414 and its manufacturing method. New antifungal antibiotic represented by general ...
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WO/1995/007303A1 |
Method for oxidising carbohydrates having a primary hydroxyl group, such as starch, inulin and fractions and derivatives thereof, by treatment with hypohalite in the presence of a catalytic amount of ditertiary-alkyl nitroxyl, in particu...
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WO/1995/007285A1 |
A novel disaccharide derivative represented by chemical formula (I), stereochemical isomers and salts thereof, and a pharmaceutical composition containing the same as the active ingredient. The compound has various biological activities ...
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WO/1995/005389A1 |
The invention provides glycoconjugates which bind polynucleotides in a sequence-selective manner and/or preferentially displace or inhibit binding of transcription factors to their recognition sites on DNA. The DNA-binding glycoconjugate...
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WO/1995/005155A1 |
Composition for the treatment or prevention of the symptoms of connective tissue ageing, characterized in that it contains one or more oligosaccharides with 2 to 5 oligosaccharide residues or a derivative of said oligosaccharide(s) conta...
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WO/1995/005182A1 |
The present invention relates to bridged oligosaccharide(s) compounds and sulfated derivatives thereof having the structure R1-[X1-R2]n-X2-R3 wherein R1, R2 and R3 are independently one or more saccharide(s); X1 and X2 are independently ...
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WO/1995/003059A1 |
The invention relates to bivalent sialyl lewis X saccharide compounds that inhibit cellular binding to a selectin receptor. Pharmaceutical compositions comprising the compound of Formula (I) and processes for making and using the same ar...
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WO/1995/003315A2 |
A library comprises at least six different sugar-containing molecules selected from (i) carbohydrates each derived from at least two saccharide monomers, and (ii) glycoconjugates. Such a library may comprise disaccharides or linear or br...
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WO/1995/002398A1 |
Pharmaceutical composition for immunomodulating and adjuvant therapy containing a metabolic stressor, 2-deoxy-D-ribose and further active components, i.e. ribose, DL-alanine, nicotonic acid, L-ascorbic acid, thiamin and glutamic acid ami...
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WO/1994/028889A1 |
The present invention relates to individual, well-defined compounds and the uses of these compounds, alone or in conjunction with bioactive molecules such as growth factors or metalloproteinase inhibitors, for the repair of cartilage dam...
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WO/1994/028909A1 |
Anti-cancer compositions containing chiral monosaccharides and methods of their use are disclosed herein. The compositions, exhibiting cytostatic and cytotoxic properties with regard to neoplastic cells are formulated using the L-isomeri...
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WO/1994/028008A1 |
Fluorescent tagging compounds of formula (I), wherein A is a member selected from the group consisting of an aromatic ring, a heteroaromatic ring, and a heterocyclic ring, and R is a linking moiety having from 1 to 20 carbon atoms, optio...
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