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WO/1998/004270A1 |
The invention relates to the use of at least one oligosaccharide comprising from 2 to 6 oside residues, and having a galactose residue in the non-reducing terminal position, or of a derivative of such an oligosaccharide substituted by a ...
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WO/1998/003554A1 |
A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly...
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WO/1998/003528A1 |
Sucrose ester and ether products, useful as food or beverage bulking agents, reduced calorie sweeteners, fat replacement agents, stabilizing agents, thickening agents and emulsifying agents; adhesives; biodegradable plastics and films; s...
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WO/1998/002041A1 |
The present invention provides therapeutic compositions derived from sugar cane which are useful for treating a variety of pathological conditions in animals, particularly humans, including those caused by inflammation; bacterial, viral,...
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WO/1997/048711A1 |
The invention relates to dendrimers comprising an initiator core with at least two functional groups and at least two saccharides. It also relates to the use thereof for various purposes e.g. as a catalyst in enantioselective syntheses, ...
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WO/1997/047634A1 |
The invention discloses the compounds of formula (I): R1 = H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy; R2 = H, Hal; R3 = H, alkyl, Hal, R4 = (a) where Rg and Rh are H, alkyl, an aryl heterocycle; R5 = H or O-alkyl;...
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WO/1997/045436A1 |
The invention relates to carbohydrate derivatives of formula (I), a process for their production and their use.
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WO/1997/042339A1 |
The present invention relates to an improved process for producing D-allose and allite from saccharose via the intermediate stages 3-ketosaccharose, allosaccharose, iso-invert sugar allose, in which the saccharose is oxidised to 3-ketosa...
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WO/1997/034907A1 |
A modified pecting material has a rhamnogalacturan backbone with side chains of neutral sugars dependent therefrom. The first group of side chains comprises relatively short, straight, chains of neutral sugars, and a second group of side...
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WO/1997/034861A1 |
A process is provided for preparing polyhydroxycarboxylic acids by the selective oxidation of di-, tri-, oligo- and polysaccharides in an alkaline medium using an oxygenous gas in the presence of Pd on a carrier as catalyst and Bi as pro...
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WO/1997/034581A1 |
Methods for the preparation of a single phase preparation comprising a hydrophilic species, e.g. a protein, solubilised in a hydrophobic phase are provided. The methods of the invention can be used in the preparation of a pharmaceutical,...
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WO/1997/034584A1 |
Carriers for delivering medicinal, nutritional, plant-protecting or cosmetic active principles are disclosed. One of the essential aims is to provide biocompatible, biodegradable, non-immunogenic, stable, solvent-free active principle de...
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WO/1997/032590A1 |
Breast cancer cells, melanoma cells and other types of cancer cells express the GLUT5 transporter and thus can accumulate significant amounts of fructose within the cell. GLUT5 is not expressed in normal breast cells or melanocytes, and ...
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WO/1997/030984A1 |
Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their...
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WO/1997/031006A1 |
Compounds that possess selection binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or thei...
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WO/1997/030061A1 |
Methods of synthesizing ganglioside GM2 are disclosed. The methods comprise reacting a trisaccharide compound with a glycosyl donor compound in the presence of a catalyst.
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WO/1997/030063A2 |
Methods are described for preparing surface-active lactose derivatives with lactose being aminated reductively, in a one-step process, using a C1-C20 alkylamine and hydrogen in the presence of a transition metal catalyst; or lactose bein...
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WO/1997/028174A1 |
Sialyl-Lewisa and sialyl-Lewisx epitope analogues, in which the natural N-acetyl group of the N-acetylglucosamine monomer is replaced by various hydroxylated aromatic substituents.
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WO/1997/028173A1 |
Sialyl-Lewisx and sialyl-Lewisa epitope analogues in which the naturally occurring N-acetyl group of the N-acetylglucosamine monomer is replaced by various aliphatic or aromatic substituents and the L-fucose naturally present is replaced...
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WO/1997/023637A1 |
The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Gal'alpha'1-3Gal), GlcNAc'beta'1-3Gal, 'alpha'- or 'beta'-glycoside...
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WO/1997/021718A1 |
A process for preparing crystalline 1-kestose which enables crystalline 1-kestose in large fine granulated sugar form to be prepared with high recovery. The process comprises concentrating a high-purity 1-kestose solution to a Brix of no...
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WO/1997/021838A1 |
A composition containing sugar microcrystals is disclosed. Essentially, the crystals are uniform unbroken single crystals with a regular geometrical shape and a grain size following a Gaussian distribution of which the median is of aroun...
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WO/1997/020860A1 |
The invention relates to a process for the alcaline oxidative degradation of an ose, an ulose, polymers or mixtures thereof in aqueous solution and in the presence of a redox couple comprised of a mixture of monosulfonic anthraquinone-2-...
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WO/1997/017464A1 |
There is disclosed the use of O-'beta'-D-galactopyranosyl-D-xyloses, particularly 2-O-'beta'-D-galactopyranosyl-D-xylose and 3-O-'beta'-D-galactopyranosyl-D-xylose, for the preparation of compositions and solutions intended to the evalua...
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WO/1997/016455A1 |
Hypocholesterolemic sugar-substituted 2-azetidinones are dislcosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar-substituted 2-az...
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WO/1997/014707A1 |
The present invention relates to analogues of sialyl (Lex) that inhibit cellular adhesion between a selectin and cells that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates and metho...
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WO/1997/012892A1 |
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte bin...
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WO/1997/010250A1 |
The present invention relates to the discovery and purification of a novel glycophospholipid that contains an antigenic determinant for human thyroid stimulating immunoglobulins (TSI's). Such glycophospholipid has utility as a reagent fo...
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WO/1997/010249A1 |
The present invention relates to a glycoconjugate immunoreactive with Toxoplasma gondii antibodies, (monoclonal) antibodies against these glycoconjugates, and cell lines capable of producing monoclonal antibodies. The invention is furthe...
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WO/1997/007810A1 |
Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further...
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WO/1997/008207A1 |
Sialyl-Lewis X derivatives wherein the 2-hydroxyl group of fucose has been substituted by a fluorine atom as represented by general formula (I-1) and intermediates for use in synthesizing the derivatives.
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WO/1997/008181A1 |
The flowability of crystalline sucralose can be increased by treating the crystalline material in a fluidised bed at ambient temperature with additions of water, followed by a fluidised drying phase. Fluidisation by means of an upward cu...
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WO/1997/007809A1 |
Sulfated disaccharides characterized by the ability to inhibit the binding of selectin to its physiologically-relevant ligand are disclosed. Included are efficient and inexpensive methods for producing the sulfated disaccharides, and met...
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WO/1997/006810A1 |
A peritoneal dialysis solution comprising an effective amount of an acetylate or deacetylated amino sugar and/or combinations thereof.
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WO/1997/006176A2 |
Tyrosine sulfate on PSGL-1, particularly at least one of residues (46, 48) and (51), functions in conjunction with sialylated and fucosylated glycans, most preferably Thr-57, to mediate high affinity binding to P-selectin. PSGL-1 O-glyca...
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WO/1997/004791A1 |
A process for preparing an antiviral agent that can inhibit the growth of viruses, is efficacious against retroviruses, does not adversely affect humans, domestic animals and so forth, and has preventive effects, which comprises extracti...
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WO/1997/003995A1 |
The present invention provides a method of synthesizing an allyl pentasaccharide having structure (I) as well as related oligosaccharide ceramides and other glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer ...
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WO/1997/001568A1 |
The present invention relates to prevention and treatment of thromboembolic diseases by administration of a therapeutically effective dose of an active trisaccharide comprising an iduronic acid, a glucopyranosyl or glucopyranosylamine un...
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WO/1997/000075A1 |
An ameliorant for pruritus cutaneous accompanying renal failure and a remedy for renal failure and complications thereof, both containing as the active ingredient at least one member selected among oligosaccharides including fructooligos...
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WO/1996/041636A1 |
An antiasthmatic agent containing a glycolipid derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein X represents either of the groups of formulae (A) and (B); n is ...
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WO/1996/040225A1 |
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier protein, wherein the resultant conjugate has be...
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WO/1996/040169A1 |
The present invention is directed to a method of treating respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenzae, Burkholderia (Pseudomonas cepacia) and a mixture...
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WO/1996/040700A1 |
Human immunodeficiency viruses (HIV-1 and HIV-2) are known to be the etiological agents of acquired immunodeficiency syndrome (AIDS). The carbohydrate structures on the virus coat proteins, gp120, are necessary for cell-cell fusion. The ...
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WO/1996/040198A1 |
The present invention provides a process for synthesizing a glycopeptide having structure (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are each independently H, OH, ORi, NH2, NHCORi, F, CH2OH, CH2ORi, or a substituted or unsubstituted ...
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WO/1996/039411A1 |
Novel substituted liposaccharides useful in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are method...
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WO/1996/039153A2 |
Adverse inflammatory reactions can be treated by administrating to an organism a composition having diglucosylamine as the active ingredient. The preferred compound is di-Beta-D-glucopyranosylamine. A simple method for making diglucosyla...
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WO/1996/037502A1 |
Neoglycoconjugates and new intermediates for the synthesis thereof are synthesized by use of Endo-'beta'-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) in a medium containing organic solvent. Such methods allow for the ...
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WO/1996/037501A2 |
The invention concerns a complex process for preparing alkyloligoglucosides with a high degree of oligomerization (degree of polymerization = 1.6 to 2.0), wherein: (a) fatty alcohols and glucose are subjected to acidically catalyzed acet...
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WO/1996/035801A1 |
The invention concerns an improved method for the enzymatic galactosylation of monosaccharides and oligosaccharides with in situ regeneration of the nucleotide sugar (or the nucleoside diphosphate sugar) in the presence of saccharose syn...
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WO/1996/035700A1 |
The present invention describes glycomimetic saccharopeptides of formula (I): W-(X)n-Y-[(X)n-W-(X)n-Y]m-(X)n-W, wherein W is independently selected from the group consisting of a) saccharides; b) aryl, aralkyl; c) alkyl of 1 to 8 carbon ...
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