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JPH0469152B2 |
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JPH04505462A |
The present invention concerns steroidic 5 alpha -reductase inhibitors having the formula: As a result of their 5 alpha -reductase inhibiting activity, these compounds are useful in the treatment of androgen dependent conditions and dise...
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JPH0458479B2 |
A novel process for the preparation of a 16-imino-17-aza-steroid of the formula I wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula II wherein A has the above definition...
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JPH04230297A |
PURPOSE: To provide a new compound having testosterone-5α-reductase inhibition activity and as pharmaceutical for preventing androgen excess irritation or reducing its symptom, and used for remedy of such as benign prostatic hypertrophy...
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JPH04230296A |
PURPOSE: To provide a new compound for preventing and reducing symptom of high androgen stimuli as testosterone-5α-reductase inhibitor, and being used as remedy such as acne, seborrhea, female hypertrichosis, male alopecia, prostatic hy...
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JPH04230294A |
PURPOSE: To provide a new compound that is effective for chemotherapy of disease due to androgen excess an anti-androgenic agent, and is locally used in the treatment of acne, seborrhea and female hypertrichosis, and generally used in th...
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JPH04230295A |
PURPOSE: To provide a new compound that prevents and reduces the sign of androgen overstimulation as testosterone reductase inhibitor, and is used for treatment of acne, seborrhea and female rough hair locally, and of benign prostatic hy...
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JPH0451157B2 |
A polycyclic antitumor antibiotic designated herein as anandimycin is produced by fermentation of Streptomyces anandii subsp. araffinosus strain C-22,437 (ATCC 31431). Anandimycin possesses antibacterial activity and inhibits the growth ...
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JPH0413327B2 |
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JPH0380154B2 |
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JPH0379351B2 |
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JPH0374228B2 |
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JPH0362718B2 |
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JPH03169891A |
NEW MATERIAL: A compound of formula I (R means H, methyl or ethyl; and R3 means 4-8C cycloalkyl). EXAMPLE: 17β-(cyclobutylcarbonyl)-4-aza-5α-androst-1-ene-3-one. USE: A 5α-reductase inhibitor useful for treatment of hyperandrogenic sy...
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JPH03163093A |
NEW MATERIAL: Compounds of formula I [R is H, methyl, ethyl; (substituted) monocyclic aryl; R', R", R"' are each H, methyl]. EXAMPLE: 17 β-(phenylcarbonyl)-4-aza-4-methyl-5α-androst-1-ene3-one. USE: Inhibitor of testosterone-5 α reduc...
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JPH03118326A |
NEW MATERIAL: To compounds are represented by formula I [ring D may have a double bond indicated by the broken line, with the proviso that a C16 -C17 double bond is not present when R<2> has a substituent group; X is keto, H or hydroxyl;...
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JPH0246566B2 |
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JPH0150206B2 |
Aromatase-inhibitors are used in a method of prophylaxis and/or treatment by therapy of prostatic hyperplasia. Pharmaceutical preparations suitable for such a use comprise an aromatase-inhibitor. A particularly preferred aromatase-inhibi...
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JPH0149358B2 |
Pregnane cpds. of formula (I) are obtd. from cpd. (II) by oxidn., then either redn., reacting with HX, dehydration, oxidn., reacting R1Y and reducing/RNH2, RNH2/HCO2H or reducing or sequence of corresp. reactions. In the formulas, A=H or...
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JPH0123478B2 |
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JPH0121829B2 |
22R, 23R-Homobrassinolide of the formula: …… which is useful as a plant growth regulator.
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JPS6419094A |
NEW MATERIAL: The compd. of formula I (R1 and R2 are each H, lower alkyl or lower acyl; R3 and R4 are O to which both are together double bonded or H to which both are single bonded or OH). EXAMPLE: The compd. of formula II. USE: An anti...
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JPS6365080B2 |
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JPS6361315B2 |
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JPS6353990B2 |
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JPS63192800A |
4-Aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, processes for their preparation, pharmaceutical compositions contaning them and their use in the...
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JPS63139196A |
17 beta -Acyl-4-aza-5 alpha -androst-1-en-3-ones of the formula: wherein R is selected from hydrogen, methyl and ethyl R<2> is methoxy, a monovalent radical selected from straight and branched chain alkyl of from 1-12 carbons, or monocyc...
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JPS63501217A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6354394A |
NEW MATERIAL:A compound expressed by formula I (R2 is H, OH or trifluoroacetoxy when R1 is methyl; R2 and R3 together form π bond; R1 and R2 together form methylene; R3 is H; R4 and R5 are H or R4 and R5 together form π bond; R6 is H o...
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JPS62242696A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS62167797A |
PURPOSE: To readily obtain the titled compound useful as a phytohormone, by reacting a specific novel steroid with a peracid in an inert solvent. CONSTITUTION: 1mol novel steroid expressed by formula I [R1 and R2 are H or OH-protecting g...
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JPS6224432B2 |
New hexanor-brassinolid-22-ethers are disclosed, of the formula I wherein Z is the group OR2 and OR3 are oriented cis 2 alpha , 3 alpha or 2 beta , 3 beta , R2 and R3 are the same or different and are each hydrogen formyl, C2-C7-alkyl-CO...
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JPS627195B2 |
Novel 28-methyl-brassinosteroid derivatives of the general formula I (in which Z represents -CO-O- CH2- or -O-CO-CH2-, and the 3 symbols R2, R3 and R22 each represents H or acyl, at least 1 of these 3 symbols representing acyl, or R22 re...
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JPS61257996A |
New 4-aza-steroid derivatives of general formula (I): …… wherein the substituents R1, X, = Y and Z have the meanings given in the specification are disclosed. Also provided for are processes for the preparation of compounds of formul...
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JPS6030653B2 |
Novel zootechnical compositions comprising a mixture of an anabolisant steroid of the formula WHEREIN R is alkyl of 1 to 4 carbon atoms, Y is selected from the group consisting of hydrogen and saturated and unsaturated alkyl of 1 to 4 ca...
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JPS6025422B2 |
1417996 Maleopimarimide derivatives ROUSSEL LABORATORIES Ltd 28 Sept 1973 [13 Oct 1972] 47437/72 Heading C2C The invention comprises compounds of formula wherein NR1R2 is an optionally substituted heterocyclic radical and Y is H, NH 2 , ...
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JPS6017794B2 |
Homobrassinolide of the formula:which shows a plant growth promoting activity.
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JPS59163319A |
PURPOSE: To provide a low-toxic antimycotic agent effective to the mycete of mammal, especially to dermatophyte, having higher activity than griseofulvin, and containing dihydrotanshinone I known as a component of TANSHIN (root of Salvia...
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JPS5955887A |
Novel brassinosteroid derivatives of the general formula I (in which R17 represents C8-C10-alkyl or -alkenyl, Z represents -CO-O- CH2- or -O-CO-CH2-, and R2 and R3 each represents H or acyl or together represent X representing H, optiona...
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JPS5824600A |
NEW MATERIAL:8,14-Anti-13,14-trans-9-azaestra-1,3,5(10)-trien-17
-on and an estrone type steroid compound (derivative) shown by the formulaI(X is H, alkyl, protecting group such as OCH3, etc.; R is H or substituent group such as alkyl). ...
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JPS581000A |
4 alpha ,5 alpha -Epoxy-3,20-dioxopregnane-2 alpha ,16 alpha -dicarbonitrile is prepared by decyclizing 4 alpha ,5 alpha -epoxy-20-oxopregn-2-eno-[2,3-d]isoxazole-16 alpha -carbonitrile with strong base and is useful as an inhibitor of m...
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JPS5652920B2 |
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JPS5637991B2 |
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JPS55149300A |
NEW MATERIAL:The titled compound of formula I (R is lower alkoxy group; R1 is H, lower alkyl, or alkoxycarbonyl group; R2 is H or alkoxycarbonyl group; R3 and R4 are H, halogen, acetyl, alkoxycarbonyl, or nitrile group; R2 and R3 may for...
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JPS5448799A |
The invention relates to new 3-amino-17a-aza-D-homo-5 alpha -androstane derivatives of the general formula I I wherein R1 represents a methylene or an >N-CH3 group, and n stands for 1 or 2, and the acid addition salts and the quaternary ...
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JPS5422356A |
D-Homo oxasteroids and processes for their preparation, which can be used as anti-inflammatory agents, the steroids having the formula or the 1,2-dehydro derivative thereof; wherein R1 is hydrogen, alkyl-@-O-, aryl-@-O-, halogen or hydro...
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JPS5262268A |
PURPOSE: Title compounds of formula I (R2 is 1W5C lower alkyl;R2 is H, 1W5C lower alkyl;one of R3 and R4 is OH or 1W5C acyloxy, and the other is H or 1W5C lower alkyl, ethynyl, 7W8C aralkyl, or R3 and R4 in combination is oxo; X is O,X);...
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JPS5125232B1 |
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JPS50151876A |
11 beta -Alkyl-2-azaestratrienes, displaying valuable pharmacological properties, e.g. anti-viral and hypolipemic, are manufactured by a total synthesis originating with dihydroresorcinol.
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JPS5028952B1 |
1309652 4-Oxosteroids F HOFFMANN-LA ROCHE & CO AG 2 April 1970 [4 April 1969] 29521/72 Divided out of 1309651 Heading C2C The invention comprises d-, l- and dl-compounds of formula (wherein M is the remainder of the D-ring of the steroid...
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