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WO/1989/003844A1 |
An artificial peptide having an amino acid sequence which corresponds to a naturally occurring amino acid sequence of an HIV comprising an epitope and which further has two cysteine residues located on each side of said epitope, and furt...
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WO/1989/003849A1 |
Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligon...
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WO/1989/003041A2 |
A tridentate conjugate has three chemical moieties, or tridentate members, attached through an appropriate spacer moiety. At least two of the tridentate members are relatively small molecules, usually less than about 7,000 Daltons in siz...
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WO/1989/001335A1 |
Biocompatible polymers having immobilized biologicals which retain a high specificity for binding pathological effectors, specific groups of pathological effectors or specific body fluid components are disclosed.
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WO/1989/000195A1 |
Immobilization method comprising mixing with polyazetidine, dewatering, sub-dividing and curing. The method is useful for enzymes, cell mass, coenzymes and antibodies. The product is physically strong, and less cross-linking agent can be...
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WO/1988/009346A1 |
There is described a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000 and having the formula (I): B-X-(PS)-X-(H), in which PS is a polysaccharide of molecular weight from about 2,000 to about 2,000...
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WO/1988/008852A1 |
Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to particular regions in the matrix protein of influenza virus. Salts, derivatives, and conjugates of these pol...
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WO/1988/007062A1 |
Azlactone-functional polymer beads are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic su...
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WO/1988/006039A1 |
Peptides which have laminin-like activity are useful in blocking tumor metastases and are active in cell migration and cell adhesion. All of the subject peptides have the amino acid sequence tyrosine-isoleucine-glycine-serine-arginine.
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WO/1988/005307A1 |
Agents appropriate as diagnostic means and as immunization agents (vaccines) of intracellular parasites, said agents being comprised of liposomes sensitized to antigenic molecules specific to intracellular parasites, for example tubercul...
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WO/1988/005074A1 |
A wafer (10) for synthesizing biopolymers includes a retaining ring (16), solid phase support material (22) and porous members (18, 20) at respective ends of the retaining ring (16). The porous members (18, 20) are maintained in position...
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WO/1988/004323A1 |
A method for preparing a 1-amino-1-deoxyoligosaccharide comprising reacting, at a pH of at least 6.5, a glycopeptide or glycoprotein containing one or more Asn-linked oligosaccharides with a beta-aspartylglycosylamine amidohydrolase.
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WO/1988/003950A1 |
DNA fragment containing at the most 315 pairs of nucleotides, characterized in that it codes for a peptide susceptible of being recognized by antibodies which are active both against the ''C'' and ''D'' particles of a same poliovirus and...
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WO/1988/003412A1 |
A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at p...
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WO/1988/003174A1 |
A highly sensitive and specific monoclonal-immuno-radiometric assay (M-IRMA) for hCG, using monoclonal antibodies (Mabs) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl terminus (CTP) of beta-hCG. Accordi...
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WO/1988/002862A1 |
It has been a problem that the known LAL method of endotoxin assay suffers from batch-to-batch differences in sensitivity, does not measure absolute amounts of endotoxin and gives some false positives. The assay of the invention quantita...
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WO/1988/002756A2 |
D�riv� de sucre d'un peptide biologiquement actif, lequel d�riv� pr�sente une dur�e d'action prolong�e par comparaison avec le peptide non modifi� par du sucre, et renferme, au moins sur l'une des unit�s amino-acides, u...
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WO/1988/002776A1 |
A stable activated affinity support having single aldehyde functionalities at the termini of extended spacer arms. The support allows covalent attachment of proteins and ligands under physiological conditions with a maximal retention of ...
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WO/1988/001279A1 |
A surface for the growth of cells is prepared by immobilizing an indole selected from the group containing serotonin, tryptamine, L-tryptophan and analogues thereof to an appropriate substrate and then exposing the indole to adhesive ser...
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WO/1988/000471A1 |
Composition and method for induction of a neutralizing antibody against the viral causative agents of AIDS and ARC. The composition is a conjugate of a polyamide resin and a synthetic peptide, the amino acid sequence of the synthetic pep...
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WO/1988/000055A1 |
Water-soluble macromolecular conjugate of hemoglobin, characterised in that it is comprised of, on the one hand, hemoglobin, and on the other hand a water-soluble polymer P comprising polar groups which macromolecular conjugate has sites...
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WO/1987/007906A1 |
Two variants of LAV viruses capable of causing acquired immunosuppressive syndrome (AIDS), which virus variants have been designated as LAVELI and LAVMAL. Their DNAs and antigens can be used for the diagnostic of AIDs or pre-AIDS.
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WO/1987/006267A1 |
Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the antigen by recovering polysaccharide from cul...
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WO/1987/006007A1 |
Immobilization of a physiologically active material while keeping the function of the physiologically active material on a high level, which is conducted by immobilizing the physiologically active material onto a carrier through an alkyl...
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WO/1987/005515A1 |
A method of making a cytotoxic lectin complex having diminished non-specific toxicity by immobilizing on a solid support by a covalent linkage a ligand which has specific binding capacity for the oligosaccharide-binding sites of lectin t...
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WO/1987/005031A1 |
Conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as ...
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WO/1987/002368A1 |
New protein characterized particularly in that it is present in the serum of pregnant females and normally absent in males; in that it is present in the serum of individuals who develop an inflammatory reaction; in that it migrates in el...
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WO/1987/001120A1 |
A method of attaching a biological substance to a solid-phase substrate for use, for example, in solid-phase immunoassays, comprises the steps of: (i) subjecting the solid-phase substrate to ion bombardment, and (ii) contacting the treat...
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WO/1986/007365A1 |
Product resulting from the conjugation of a hapten and a muramyl-peptide to a macromolecular support, said product having selective immunogenic properties with respect to antigenes having in common an antigenic site or an epitope in comm...
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WO/1986/006635A1 |
A complex of an immunogen with a carrier molecule and a method for presentation of the immunogen to mucosal epithelia of a host vertebrate in order to elicit a systemic, cellular, and/or mucosal immune response in the host vertebrate to ...
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WO/1986/005693A1 |
A diagnostic site-specific imaging reagent in the form of a receptor and an indicating means selectively binds to a specific cell membrance-associated antigen of a blood platelet that is in a stimulated active state but does not substant...
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WO/1986/003136A1 |
A dried alignate-magnetite separation media for use in affinity chromatography and enzyme immobilization. The separation media is also useful in chromatographic separations carried out in a magnetically stablized fluidized bed (1).
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WO/1986/002654A1 |
Aliphatic polyamides are reacted on their surfaces with sulphuryl chloride, either neat or in solution in paraffins or cycloparaffins to give reactive intermediate which may convert into a support capable of reaction with antibodies or e...
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WO/1986/002091A1 |
A product enabling, in the field of immunopurification, the separation of cells comprises a finely divided medium of a density lower than that of the medium wherefrom those cells have to be extracted, covered with macromolecules capable ...
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WO/1986/001902A1 |
A process for producing a polymeric product with specific binding affinity, for an antigen or antibody or member of another specific binding pair, comprising the steps of (a) forming a covalently-linked reaction product which is a deriva...
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WO/1986/001718A1 |
Method for obtaining the complex FVIII/vWF of therapeutic use having both the A hemophilic activity and the Willebrand activity, as well as a high degree of purity, which method is substantially characterized in that it provides for the ...
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WO/1985/004653A1 |
Chemically synthesized polypeptides containing about 6 to about 40 amino acid residues having amino acid residue sequences that substantially correspond to the amino acid residue sequences of antigenic determinants of interleukin-2, (P81...
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WO/1985/004418A1 |
Vector for the cloning and expression in a host cell of hirudine or an analogue of hirudine, characterized in that it comprises the gene coding for hirudine or an analogue of hirudine, and the elements for the expression of this gene in ...
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WO/1985/003934A1 |
Chemically modified proteins wherein a group R-(OCH2CH2)n- (wherein R represents a terminal oxygen-protecting group, and n represents an arbitrary positive integer) is directly bound to at least one primary amino group of a physiological...
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WO/1985/003868A1 |
A chemically modified lymphokine having a group of R(-O-CH2CH2)n- (wherein R is a protective group for the terminal oxygen and n is an arbitrary positive integer) directly bound to at least one primary amino group of the molecule. It can...
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WO/1985/003508A1 |
Toxin conjugates for selective destruction of target cells. Some embodiments employ spacer peptides between the cytotoxic and binding regions of the conjugates to facilitate translocation and intracellular cleavage after binding to the t...
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WO/1985/001941A1 |
A method of isolating a protein from a mixture containing the protein, the method including providing an antibody immobilized on a solid support, which antibody is reactive with the protein complexed with a ligand and substantially unrea...
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WO/1984/004756A1 |
A process for the production of a fusion protein comprising an active portion of a chloramphenicol acetyltransferase (CAT) protein and a polypeptide. The fusion protein may be purified using CAT substrate affinity chromatography. The euc...
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WO/1984/004525A1 |
There is described a method for splitting at least one disulphide bond -S-S-, where each of the sulphur atoms is directly bound covalently to its respective aliphatic carbon atom in an organic substance which contains at least one such d...
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WO/1984/003358A1 |
A composition is set out which has improved selectivity and sensitivity for use in immunoassays. The composition comprises a solid support having a surface partially coated with a polysaccharide and elsewhere not covered by such a coatin...
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WO/1984/003103A1 |
A method of producing and selectively isolating a desired protein or polypeptide or derivative thereof by constructing a recombinant vector comprising a DNA sequence coding for said desired protein or polypeptide operatively linked to a ...
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WO/1984/003053A1 |
A modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly...
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WO/1984/003087A1 |
Synthetic polypeptides and their conjugates bound to a carrier along with antibodies raised thereto, and methods of their use. The amino acid residue sequences of the synthetic polypeptides correspond substantially to an amino acid seque...
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WO/1984/001149A1 |
A novel polypeptide represented by the following formula: H-Lys-Arg-Lys-Arg-Ser-Gln-Met-Leu-Phe-Arg-Gly-Arg-Arg-Ala-Se
r-Gln-OH and a conjugated protein thereof, hybridoma and monoclonal antibody induced from said polypeptide or said con...
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WO/1984/000540A1 |
A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 180 amino acid residues and the formula:$(15,)$The polypeptide or a biologically active fragment thereof, such as$(6,)$can be employed in the preparatio...
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