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WO/2000/012587A2 |
Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble o...
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WO/2000/012536A2 |
The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefold...
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WO/2000/010599A2 |
Novel immunogenic $g(b)-propionamido-linked polysaccharide- and N-propionamido-linked oligosaccharide-protein conjugates are provided as well as method of producing the conjugates. The conjugation procedure is simple, rapid, reproducible...
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WO/2000/009165A1 |
The present invention relates to dextran-leptin conjugate compositions, and related methods of preparation, methods of use, and pharmaceutical compositions.
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WO/2000/009073A2 |
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier and to methods of making and using such conjugates. Amphiphilic drug-oligomer conjugates comprise a therapeutic compound ...
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WO/2000/007019A1 |
The preparation of new water-soluble cross-linked conjugates and cross-linked conjugate complexes improves the detection ability of immunochemical assays, including lateral flow devices, and relies on a 'salting-out' process in which a r...
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WO/2000/006726A2 |
Nucleic acid sequences are disclosed which encode polypeptide members of the Delta family of mammalian membrane surface-bound ligands; such sequences can be used, among other things, for chromosome mapping and analysis and to produce the...
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WO/2000/004863A2 |
Compositions and methods for preventing or treating primary cancer cell growth and tumor metastasis, as well as stimulation of hematopoiesis are described and claimed. The present invention also relates to methods of treating cancer and ...
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WO1999051773A9 |
Disclosed herein are arrays of nucleic acid-protein fusions which are immobilized to a solid surface through capture probes which include a non-nucleosidic spacer group and an oligonucleotide sequence to which the fusion (such as an RNA-...
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WO/2000/004044A1 |
A glycopeptide of the formula A¿1?-A¿2?-A¿3?-A¿4?-A¿5?-A¿6?-A¿7?, in which each dash represents a covalent bond; wherein A¿1? comprises a modified or unmodified -amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkano...
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WO/1999/061912A1 |
The invention concerns molecular rods, their uses in a method for fixing and/or crystallising macromolecules, the resulting products and uses of said products in the field of materials and structural biology, in particular as biosensors ...
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WO/1999/061459A1 |
The invention provides isolated nucleic acids molecules, designated hALG-2LP, sALG-2LP, and mALG-2LP nucleic acid molecules, which encode proteins involved in the modulation of programmed cell death. The invention also provides antisense...
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WO/1999/057564A1 |
The invention concerns a method for immobilising and/or crystallising macromolecules, chemical reagents used in said method, resulting products and uses of said products in the field of materials and structural biology, in particular as ...
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WO1999042597A9 |
The present invention is directed to the field of immunology. In particular, the present invention is directed to the design, production, and use of monovalent, multivalent and multimeric Major Histocompatibility Complex binding domain f...
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WO/1999/056126A2 |
The invention relates to a novel immuno-adsorption matrix, a method for the production thereof, and the utilization thereof for therapeutic, diagnostic, preparative, analytic and medicine technological purposes. By coupling to a supporti...
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WO/1999/055900A2 |
The invention provides gcp polypeptides and polynucleotides encoding gcp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gcp polypeptides to screen for antibacte...
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WO/1999/055309A1 |
The invention concerns novel microspheres particularly useful in pharmaceutics as particulate vectors for carrying biologically active substances, in particular hydrophilic substances, for oral administration. The invention is characteri...
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WO/1999/054729A2 |
The invention relates to a method for fixing substrate molecules in gel matrices. Said method is characterized in that a substrate is covalently linked to a monomeric or oligomeric structural unit of a gel and the resulting product is po...
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WO/1999/052933A1 |
This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one b...
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WO/1999/053321A1 |
The invention concerns a method for fixing a biological molecule, associated with a specific binding site, on the surface of a support made of silica or metal oxide. The invention also concerns a surface functionalised by the method and ...
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WO/1999/048918A1 |
The present invention relates to subtilisin protease conjugates comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a parent amino acid sequence, the parent ami...
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WO/1999/048513A1 |
The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to sy...
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WO1996012802A9 |
The present invention provides neutralizing antitoxin directed against C. difficile toxins. These antitoxins are produced in avian species using soluble recombinant C. difficile toxin proteins. The avian antitoxins are designed so as to ...
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WO/1999/043816A1 |
Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of ...
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WO/1999/042605A1 |
A method for the solid-phase synthesis of combinatorial libraries on a one-dimensional support, such as a thread, is provided. The method involves the cyclic permutation of structural features along the thread, in such a way that differe...
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WO1999028475A9 |
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism...
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WO/1999/042118A2 |
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptide...
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WO/1999/040122A1 |
The invention relates to a method for producing a bead-shaped, cross-linked hydrophilic mixed polymer which actively bonds with ligands with nucleophilic groups, by inversely bead-polymerising a monomer phase. The invention also relates ...
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WO/1999/036552A1 |
The invention relates to a method for producing a purified recombinant TSH receptor preparation (rTSHR preparation). According to said method, a recombinant fusion-TSH-receptor is produced with an additional amino acid sequence inserted ...
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WO/1999/036570A2 |
Methods, products and kits are provided for attaching agents to body tissues using transglutaminase.
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WO1999019363B1 |
The present invention is directed to monoclonal antibodies which specifically bind to a Limulus alpha 2-macroglobulin. Preferred monoclonal antibodies inhibit the enzymatic activation of a Limulus amebocyte lysate to form a gel or to cle...
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WO/1999/035289A1 |
Arrays of polymeric targets stably associated with the surface of a rigid solid support are provided. In the subject arrays, the polymeric targets are arranged at least according to size. The polymeric targets of the subject arrays are g...
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WO/1999/035499A1 |
The present invention is related to a method for the detection and/or the quantification of a target molecule by its binding with a non-cleavable capture molecule fixed on the surface of a disc comprising registered data. The present inv...
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WO/1999/032520A1 |
An assay method commonly usable in the clinical field whereby denatured LDLs such as oxidized LDL contained in the body fluids of patients with arteriosclerosis, hyperlipemia, etc. can be conveniently detected and quantitated in an intac...
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WO/1999/032513A1 |
This invention relates to a protein binding polypeptide not directly derived from a natural ligand binding protein known to bind protein, the protein binding polypeptide comprising 2 to 30 amino acids and the uses of the polypeptide.
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WO/1999/032134A1 |
Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under conditions sufficient to facilitate covalent att...
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WO/1999/027104A1 |
The present invention relates to histamine and serotonin binding molecules that possess a binding site with the precise molecular configuration that is necessary to confer on the molecule a high affinity for histamine. The invention incl...
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WO/1999/024458A1 |
An assembly of a carrier having one or more reporter beads non-covalently attached thereto which may be used in relation of oligomer libraries. The oligomer libraries may be formed by a combinatorial split-process-recombine procedure. Th...
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WO/1999/020649A1 |
Synthetic cell membranes which are bonded to a noble metal support and which comprise novel spacer peptides of formula (I) are disclosed. These membranes can incorporate membrane proteins and can be used in biosensing devices. Peptides o...
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WO/1999/019344A1 |
The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching 'tags' that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded ...
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WO/1999/018131A2 |
The invention relates to anti-heavy chain binding protein antibodies (anti-BiP-antibodies) in the body fluids of patients with rheumatoid arthritis, and a method for their detection. The invention relates in particular to a method for de...
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WO1998051330A9 |
The present invention relates to a method of treating hyperlipidemia and to reducing triacylglycerols, glycerol and cholesterol in a patient. The method includes the step of administering a therapeutically effective amount of a type-5 se...
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WO/1999/012975A1 |
Polymer hybrid composite articles having reversible activity and dispersion stabilities having polymer whiskers either chemical tethered to or physically adsorbed on the surfaces of medically or industrially active and important bioactiv...
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WO/1999/012036A1 |
This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag...
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WO/1999/011777A1 |
The present invention provides novel methods of protein/polypeptide screening based on the provision of libraries of individual proteins/polypeptides, which in turn can be screened for cell binding, biological activity etc. Methods for r...
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WO/1999/010383A1 |
The invention relates to polysaccharide derivatives containing a) at least one hydrophobic agent and b) at least one substituent containing nitrogen. The derivative is especially a cellulose ether which, contains as a substituent, a) a t...
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WO/1999/010494A2 |
Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for tr...
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WO/1999/006440A1 |
A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable $g(a)-helix and has the following structure comprising at least 12 amino acids: R¿1?-R¿2?-A¿1?-B¿1?-(A¿2?-B¿2?-C¿1?-A¿3?)Â...
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WO/1999/006071A1 |
The present invention relates to a modified polypeptide which has an enzymatic activity level of greater than about 70 % of the parent polypeptide and an allergenic response level of less than about 33 % of the parent polypeptide. Embodi...
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WO/1999/006446A2 |
The invention relates to a method for transglutaminase-catalyzed coupling of protein or peptide to a support, while retaining at least 50 % of the biological activity of the protein or peptide. The invention also relates to the immobiliz...
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