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WO/1991/007190A1 |
The present invention relates to chemically modified hemoglobin produced by a novel and efficient method in which stroma-free hemoglobin is first effectively deoxygenated and reduced and then conjugated with a polyalkylene oxide such as ...
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WO/1991/007428A1 |
In a method of recovering proteins, an antibody raised against a peptide comprising at least a fragment of the protein is immobilized on a solid support, a crude preparation of the protein is contacted with the antibody under conditions ...
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WO/1991/006306A1 |
The production of antivenoms in non-mammals and improvements in the effectiveness of both non-mammalian antivenoms and mammalian antivenoms so that they are more suitable for treatment of humans and animals as well as for analytical use.
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WO/1991/005802A1 |
Disclosed are 1) amino acid sequence data, structural features, and various other data characterizing a human osteogenic protein, OP1, 2) osteogenic devices comprising a heat treated xenogenic bone collagen matrix containing osteogenic p...
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WO/1991/005036A2 |
An absorbed protein-independent cell-adhesive surface is disclosed. The treated surface comprises a chemically derivatized material to which small peptides, having less than 12 amino acid residues and including YIGSR, RGD or REDV amino a...
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WO/1991/004050A1 |
Disclosed are methods and compositions for the treatment of HIV infections through the specific elimination of cells which express HIV $i(env) determinants such as gp120. The compositions of the invention include toxin conjugates compose...
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WO/1991/003491A1 |
Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-beta, at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of...
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WO/1991/002768A1 |
This invention relates to radio-derivatized polymers and a method of producing them by contacting non-polymerizable conjugands with radiolysable polymers in the presence of irradiation. The resulting radio-derivatized polymers can be fur...
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WO/1991/002005A1 |
The invention relates to the use of human anti-gamma interferon antibodies in human therapy and to the detection and purification of said antibodies by means of synthetic peptides corresponding to regions of human gamma interferon.
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WO/1991/000109A1 |
An antibody-immobilizing carrier having immobilized thereto a polyclonal antibody or monoclonal antibody capable of selectively removing harmful substances or colored substances from blood or serum is disclosed. This carrier having the a...
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WO/1991/000296A1 |
The invention provides a means for attaching a label, support or bioactive agent to the protein at a site that is remote from the active site of the protein. More specifically the invention is directed to a method for the attachment of a...
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WO/1990/015614A1 |
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. These epitopes are present on IgA-bearing B cells but not the secreted, soluble form of IgA. T...
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WO/1990/015070A1 |
A method and device for preparing desired sequences on a substrate at known locations. Known locations (10) of a substrate (2) are irradiated by way of a mask (8) so as to activate a material (4) for binding. The substrate is then expose...
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WO/1990/015071A1 |
Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, th...
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WO/1990/014361A1 |
Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to particular regions in the matrix protein of influenza virus. Salts, derivatives, and conjugates of these pol...
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WO/1990/013540A1 |
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in...
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WO/1990/013561A1 |
This invention relates to chymopapain, improved pharmaceutical compositions containing chymopapain and to methods of treating damaged, herniated or otherwise abnormal intervertebral mammalian spinal discs which comprise injecting into sa...
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WO/1990/012807A2 |
A method of identifying epitopes to gene products, specifically the human retinoblastoma (Rb) gene and the corresponding antigenic polypeptides. The amino acid sequence has a combination of low solubility and high hydrophilicity. Highly ...
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WO/1990/011778A1 |
Multiple antigen peptide systems are described in which a large number of each of T-cell and B-cell malarial antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low mole...
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WO/1990/012092A1 |
A process is described for the immobilization of proteins, peptides, ligands, coenzymes, redox mediators, etc., on a substrate with amino, mercapto or hydroxy groups. The substrate is reacted with a compound of general formula (I) or (IA...
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WO/1990/011297A1 |
The invention provides a method of attaching peptides containing a RGD adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such ...
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WO/1990/010450A1 |
Methods are described for making specific monoclonal antibodies which may be used in a sensitive immunoassay for detection of synthetic pyrethroids in foods and environmental samples. Appropriate sample preparation and enzyme amplificati...
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WO/1990/009798A1 |
The present invention provides immobilized cytokines comprising cytokines bound to a solid, preferably biologically inert, support. The bound cytokine, for example IL-2, retains comparable biological activity when bound to the support. A...
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WO/1990/010228A1 |
A family of metalloproteinases exist which cleave extracellular matrix molecules. These metalloproteinases are secreted in a latent inactive form and require activation in order to specifically cleave the preferred substrate. A series of...
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WO/1990/009395A1 |
A method for the separation of at least one specific binding entity from a mixture of binding entities, comprises the steps of contacting said mixture of binding entities with an immobilized peptide in which said peptide specifically bin...
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WO/1990/008783A1 |
The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore component...
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WO/1990/008834A1 |
The present invention provides monoclonal antibodies directed against specific domains of fibronectin and vitronectin. These monoclonals may be used in the production of the biomaterial and devices for use in in vitro cell culture. The p...
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WO/1990/007934A1 |
A catalytic molecule comprising a receptor molecule containing an antibody combining site that immunologically binds to a plurality of polyvalent metal ion-containing coordination complexes is disclosed. The coordination complex of a fir...
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WO/1990/006774A1 |
Novel compounds and methods for the formation of disulfide linkages are presented. The novel compounds employed are substituted 2-iminothiolane hydrohalide linking agents of formula (I), wherein X is halogen; R1 is COOR5; halogen; nitro;...
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WO/1990/006952A1 |
This invention provides a chemically modified protein prepared by combining polyethylene glycol with a polypeptide having substantially the following amino acid sequence and comprising the product of manifestation by a host cell of a for...
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WO/1990/006763A1 |
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises ...
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WO/1990/006767A1 |
A conjugate of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, such as hyaluronic acid or chondroitin sulfate is disclosed. Methods of making the conjugate and using it to aid wound healing by providing a te...
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WO/1990/004606A1 |
A process for fractionating a mixture of polyethylene glycol (PEG)-protein adducts comprising partitioning the PEG/protein adducts in a PEG-containing aqueous biphasic system.
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WO/1990/002558A1 |
A polymer of the formula P-(L-R)q, wherein P is a polymer comprising at least one unit of the formula (AmBn), wherein (AmBn) is substantially nonbiodegradable and has an average molecular weight of about 1,000 to 500,000 daltons, m and n...
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WO/1990/000609A1 |
Novel polypeptide compositions and methods for their use are provided comprising fusion proteins capable of binding to a polysaccharide matrix. The compositions may be synthesized or prepared by recombinant DNA technology.
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WO/1989/012459A1 |
The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X1MHC2peptide or MHC2peptide1X, wherein X represents a functional moiety selected from a toxin and a lab...
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WO/1989/011865A1 |
Novel hybrid cell lines produce monoclonal antibody to the light chain region of human factor XII. Three such cell lines, ATCC #HB-9703 through ATCC #HB-9704, are formed by fusing SP2/0-Ag14 myeloma cells with spleen cells from BALB/c An...
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WO/1989/011270A1 |
The invention relates to liposomes coupled to a hormone e.g. a cytokine in which the hormone retains specific binding activity to its cell membrane receptor and to a process for making them. The liposomes of the invention may be used as ...
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WO/1989/010735A1 |
A multi-functional mammalian peptide probursin isolated in purified form, produced synthetically or recombinantly can be used therapeutically for treatment of immune disorders and tumor inhibition.
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WO/1989/010377A1 |
There is disclosed a method for producing extremely tight binding of proteins to surfaces and to a protein surface wherein the protein is tightly bound to the surface.
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WO/1989/010348A1 |
It has been found that by using dimethyl formamide as a part of the solvent, the Albertson method for preparing amino acids can be applied to the preparation, in good yield, of long-chain aliphatic amino acids, previously obtainable only...
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WO/1989/009064A1 |
Synthetic polypeptides from the conserved exposed region of streptococcal M protein are useful to prepare vaccines for oral or intranasal administration which will protect against streptococcal infection.
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WO/1989/009406A1 |
In the process disclosed, the support is a structure consisting of at least one layer of molecules containing identical proteins extending along a flat, curved, cylindrical or vesicular surface, the molecules being arranged in the form o...
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WO/1989/009233A1 |
Methods of stabilizing the three-dimensional conformations of proteins using "molecular sticks" to bridge and constrain tertiary protein structures are disclosed. These "molecular sticks" contain rigid multimeric spacer portions of vario...
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WO/1989/007944A1 |
The invention includes a device and method. The device is a site directed neovascularization device. The device includes a biocompatible support. The device also includes a biological response modifier for inducing neovascularization. Th...
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WO/1989/007111A1 |
Disclosed are novel polypeptide compounds which promote the release and elevation of growth hormone levels in the blood of animals. Also disclosed are methods of promoting the release and elevation of growth hormone levels in the blood o...
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WO/1989/007110A1 |
Disclosed are novel polypeptide compounds which promote the release and elevation of growth hormone levels in the blood of animals. Also disclosed are methods of promoting the release and elevation of growth hormone levels in the blood o...
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WO/1989/007139A1 |
The present invention relates generally to the immobilization or incorporation of polypeptides, especially enzymes or other bioactive polypeptides into polymeric matrixes, especially polyurethane, membranes produced by said polymers, and...
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WO/1989/005305A1 |
New polymer supports containing cleavable cross-links are described which are suitable for solid phase peptide synthesis and can then be solubilised for further chemical or biological manipulation (including immunisation) in solution.
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WO/1989/004675A1 |
Disclosed is a method and a family of materials useful for removing immune complexes from blood preferentially to soluble antibodies. The material comprises analogs of proteins which bind to the Fc region of immunoglobulin. The analogs a...
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