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WO/2020/240197A1 |
An ion guide or ion trap that comprises a plurality of electrodes (102) is disclosed. The ion guide or ion trap includes a detector (205) that can detect light or particles (114) emitted from the ion guide or ion trap due to electrical b...
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WO/2020/242744A1 |
A method for determining in a sample, by liquid chromatography/mass spectrometry, the presence, absence, or amount of one or more or a plurality of analytes selected. The method comprises subjecting the sample to an ionization source und...
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WO/2020/240908A1 |
A mass spectrometry method which performs mass spectrometry by generating product ions from precursor ions derived from a sample component having a hydrocarbon chain, wherein: product ions are generated by irradiating the precursor ions ...
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WO/2020/243643A1 |
Methods and systems for improved sample detection in mass spectroscopy are generally described. These are particularly useful, for example, for identifying a protein, a part of a protein, or a peptide when present in a low amount. In som...
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WO/2020/241098A1 |
Provided in the present disclosure is a spray ionization device comprising: a first tube (21) that has a first flow path (23) in which a liquid can flow, the first tube (21) having a first outlet (21a) on one end thereof from which the l...
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WO/2020/243194A1 |
An apparatus includes multiple levels of ion transport channels, with successive levels coupled by elevator channels. Efficient three dimensional packing provides long path lengths in practical volumes for ion mobility separation with hi...
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WO/2020/240510A1 |
An electrospray probe for use in an electrospray ion source is disclosed, which comprises a cannula extending from a proximal end having an inlet aperture for receiving a liquid sample containing at least one analyte to a discharge emitt...
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WO/2020/242911A1 |
The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve a probe for nano spray desorption electro spray ionization (nano-DESI) with fixed positioning of the channels therein for...
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WO/2020/240153A1 |
A method of mass filtering ions is disclosed comprising: providing a first, AC-only, mass filter (2); providing a second mass filter (4) downstream of the first mass filter; applying a first AC voltage (8) to electrodes of the first mass...
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WO/2020/234621A1 |
This invention has as its object a method of filtering an ion beam to isolate ions having a targeted charge to mass ratio, the method comprising: - providing a quadrupole mass filter device (2), - emitting an ion beam (1') from a source ...
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WO/2020/234145A1 |
Method for producing multiply-charged helium nanodroplets and charged dopant clusters and nanoparticles out of the helium nanodroplets, the method comprising: • producing neutral helium nanodroplets in a cold head (1) via expansion of ...
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WO/2020/234319A1 |
An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce ele...
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WO/2020/237037A1 |
A device including a first surface, a second surface and a controller. The first and the second surfaces define a first ion channel therebetween. The second surface includes a first plurality of electrodes with a first electrode and a se...
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WO/2020/234320A1 |
An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11) defining an ion optical path, a housing (18) for accommodating the electrodes, a voltage source for providing voltages to the electrodes to produce e...
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WO/2020/234318A1 |
An ion optical arrangement (1) for use in a mass spectrometer comprises a collision cell defining an ion optical axis along which ions may pass, electrodes comprising a set of parallel poles (11A, 11B, 11C) arranged in the collision cell...
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WO/2020/230063A1 |
Method and devices for performing top down analysis of an antibody are described which involve utilizing an ion source to generate a plurality of ions from a sample containing at least one intact antibod. Further, transmitting said plura...
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WO/2020/230297A1 |
This ion analyzer 1 is provided with: an ionization chamber 10; an analysis chamber 20 separated from the ionization chamber 10 by a partition wall 21 in which an opening 211 is formed; an ionization part 3 which generates ions from a sa...
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WO/2020/230397A1 |
A representative value is determined among from a theoretical mass group that is a collection of theoretical masses relating to a single protein in a plurality of microorganisms (step S1), a reference sequence that is an amino acid seque...
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WO/2020/228475A1 |
Systems and methods are provided for high-efficiency transport of single particles for inductively coupled plasma mass spectrometry. Single particles may be delivered to the mass spectrometer for quantification of trace elements. The sys...
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WO/2020/229819A1 |
An aperture plate assembly for an analytical instrument comprises a first sub-assembly comprising an aperture plate and a second sub-assembly comprising a guide. The first sub-assembly is configured to be attached to the second sub- asse...
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WO/2020/224005A1 |
A continuous variable pressure sampling device of an Archimedes spiral mass spectrometer, comprising an electric motor (1) and a base (20), wherein the upper surface of the base (20) is fixedly installed with a gas outlet transition cham...
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WO/2020/227541A1 |
The capabilities of a gas or liquid chromatography - molecular rotational resonance (GC/LC-MRR) instrument exceed those of high-resolution mass spectrometry and nuclear magnetic resonance in terms of selectivity, resolution, and compound...
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WO/2020/225715A1 |
Techniques and apparatus for generating encoded representations of compounds are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be conf...
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WO/2020/224006A1 |
A continuous variable-pressure sampling apparatus for a spiral mass spectrometer, comprising a cylindrical outer shell (6) and a mass spectrometry system (17), an inner cylinder (11) provided with a spiral line-type groove (12) on the ou...
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WO/2020/223341A1 |
Disclosed herein are methods and systems for ionizing organic compounds by exposing head space vapors to corona discharge. The methods and systems are suitable for high throughput screening of samples, including biofluids. The methods an...
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WO/2020/223284A1 |
Systems and methods for extracting an analyte from a sample. The system includes a reaction vessel for receiving the sample and a reaction solution, a mixer for mixing the sample with the reaction solution, a filter and a drain for passi...
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WO/2020/219605A1 |
Apparatus and methods for performing charge detection mass spectrometry for measurement of the mass of a single ion of interest are disclosed. The ion of interest is caused to undergo harmonic oscillatory movement in the trapping field o...
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WO/2020/219527A1 |
A method for analyzing charged particles may include generating, in or into an ion source region, charged particles from a sample of particles, causing the charged particles to enter a mass spectrometer from the ion source region at each...
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WO/2020/212856A1 |
The resolution of a TOF mass analyzer is maintained despite a loss of resolution in one or more channels of a multichannel ion detection system by selecting the highest resolution channels for qualitative analysis. Ion packets that impac...
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WO/2020/213283A1 |
According to the present invention, a mass spectrometer is achieved which provides evidence for the shifts of m/z values of the device while maintaining sensitivity necessary for quantitative analysis, and which supplements the ion amoun...
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WO/2020/207801A1 |
The invention relates to a method for producing a three-dimensional ion trap (10), comprising the following steps: providing a first substrate (20) and a second substrate (22); forming an insulation region (34, 36) on a first surface of ...
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WO/2020/210688A1 |
Systems and methods for sample analysis include applying, using a first laser source, a first beam to a sample to desorb organic material from a location of the sample and ionizing the desorbed organic material using a second laser sourc...
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WO/2020/200965A1 |
The invention relates to a method for determining chemical element concentrations and bonding forms in a material (2), comprising a) conveying the material (2), b) extracting a sample (5) of the material (2) conveyed according to step a)...
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WO/2020/205982A1 |
An ion trap (100) includes a first electrode pair (110) and a second electrode pair (130), each including a first conductive member (112) and a second conductive member (120) and facing each other so that the first conductive member (112...
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WO/2020/203134A1 |
Provided is a technology which accurately determines the performance of a detector single body that detects an ion passing through a mass analysis unit. A mass analysis system of the present disclosure is provided with: a first converter...
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WO/2020/202728A1 |
This ionization method comprises a first step of preparing a sample support that includes: an electric insulation substrate having a first surface, a second surface on the side opposite the first surface, and a plurality of through-holes...
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WO/2020/200833A1 |
The invention relates to a mass spectrometer (1 ), comprising: an ion trap (2), which has an interior (2a) for storing ions (4a, 4b), a signal generator (5, 6a, 6b), which is connected to an electrode (3, 7a, 7b) of the ion trap (2), whi...
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WO/2020/202455A1 |
This ion analyzer, which analyzes product ions generated by emitting radicals to precursor ions derived from a sample component, is provided with: a reaction chamber (2) to which the precursor ions are introduced; a radical emission unit...
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WO/2020/202729A1 |
This sample support is for ionization of a sample and comprises a substrate which has a first surface, a second surface opposite the first surface, and a plurality of through holes that opens to the first surface and the second surface, ...
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WO/2020/201732A1 |
A method of selecting ions comprises selecting ions corresponding to a target ion of interest by separating analyte ions according to their ion mobility, isolating first ions of the analyte ions, separating the first ions according to th...
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WO/2020/201734A1 |
A method of newborn screening ("NBS") is disclosed comprising directing ultrasonic energy or ultrasonic waves into a metabolite or analyte sample derived from a newborn, neonate or infant so as to cause a mist of charged sample droplets ...
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WO/2020/205945A1 |
Disclosed herein are methods and apparatus useful for the collection, preservation, and analysis of biological fluids. In some embodiments, a hydrophobic thread is contacted with a biological sample. The hydrophobic thread stabilizes the...
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WO/2020/202008A1 |
Methods and systems that can use a gas comprising a nitrogen center that is introduced upstream of a plasma sustained in a torch are described. In some configurations, the gas comprising the nitrogen center can be introduced as a gas ups...
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WO/2020/194095A1 |
Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of backgrou...
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WO/2020/198688A1 |
Methods, apparatuses and systems are described that are capable of simultaneously determining the presence, identities or levels of multiple analytes present in a single sample, by carrying out steps including denaturation, normalization...
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WO/2020/193726A1 |
A method of operating a collision cell (10) in a mass spectrometer is disclosed. The collision cell comprises an entrance aperture (116), an exit aperture (117) and electrodes (113, 114) for producing electric fields. The method comprise...
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WO/2020/197938A1 |
An ion source is configured to form an ion beam and has an arc chamber enclosing an arc chamber environment. A reservoir apparatus can be configured as a repeller and provides a liquid metal to the arc chamber environment. A biasing powe...
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WO/2020/196450A1 |
A device (10) is provided which provides pre-processing for gas main processing by means of a wire (52) which is heated inside a container (19) into which a gas (9) flows. This device (10) has a wire supply unit (50) which continuously o...
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WO/2020/195062A1 |
The present invention implements an ion detecting device with which it is possible to avoid direct collisions of negative ions with a scintillator, prevent degradation of the scintillator, prolong life of the scintillator, reduce the nee...
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WO/2020/196452A1 |
Provided is a gas analyzing device (1) having: a sample chamber (11) provided with a dielectric wall body structure (12) and into which flows only a sample gas (9) that is a measurement target; a plasma generating mechanism (13) that gen...
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