Title:
虚血損傷を予防または軽減するためのレチノイド似活性を有する置換（５，６）−ジヒドロナフタレニル化合物の用途
Document Type and Number:
Japanese Patent JP2001512484
Kind Code:
A
Abstract:
The present invention relates to methods of preventing, or reducing the severity of, an ischemic injury originating in an animal's dermal tissue by applying to the animal a composition comprising a compound of formula I*: or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -CH=CH-, -C 3BOND C-, -CH2-NH-, -COCH2-, -NHCS-, -CH2S-, -CH2O-, -OCH2-, -NHCH2- or -CR5=CR6-; n is 1 or 0; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; R4 is -(CH2)t-Yb, C1-6 alkyl, or C3-6 cycloalkyl; R1 is -CO2Z, C1-6 alkyl, CH2OH, -CONHRy, or CHO; Ra and Rb are independently hydrogen or C1-6 alkyl, or Ra and Rb together can form a radical of the formula: Yb is naphthyl or phenyl, both radicals can be optionally substituted with one to three of C1-6 alkyl or halogen, which substituents can be the same or different; Z is hydrogen or C1-6 alkyl; R2, R3, R5, R6, and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.
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Inventors:
シャノン，ロナルド・ジェイ
トランポッシュ，ケネス
モント，カリン・エイ
トランポッシュ，ケネス
モント，カリン・エイ
Application Number:
JP53678698A
Publication Date:
August 21, 2001
Filing Date:
February 19, 1998
Export Citation:
Assignee:
ブリストル−マイヤーズ・スクイブ・カンパニー
International Classes:
A61P25/04; A61K31/00; A61K31/192; A61K31/197; A61K31/216; A61P43/00; (IPC1-7): A61K31/216; A61K31/192; A61K31/197; A61P25/04; A61P43/00
Attorney, Agent or Firm:
青山 葆 （外１名）