Title:
癌治療用分子複合体
Document Type and Number:
Japanese Patent JP2004528309
Kind Code:
A
Abstract:
A molecular conjugate is provided having the formula: wherein R1 is a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an analog or derivative thereof, and Z is -O- or -NH-, respectively, Y is a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups; and R2 is -CH-CH(W), -CH(OH)CH(OH)W, or -C(O)H, where W can be H, a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups.
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Inventors:
McChessney, James, Dee
Chandler, Madavi, Sea
Siahan, Teruna, Jay
Shu, Christine, Earl
Ainsworth, Sterling, Case
Chandler, Madavi, Sea
Siahan, Teruna, Jay
Shu, Christine, Earl
Ainsworth, Sterling, Case
Application Number:
JP2002574963A
Publication Date:
September 16, 2004
Filing Date:
March 25, 2002
Export Citation:
Assignee:
Napro Biotherapeutics, Incorporated
International Classes:
A61K31/337; A61K31/352; A61K31/407; A61K31/4375; A61K31/56; A61K31/575; A61K31/704; A61K47/42; A61K47/48; A61P35/00; C07D305/14; C07D311/82; C07D491/22; C07H15/252; C07J9/00; C07K14/79; A61K38/00; (IPC1-7): A61K47/48; A61K31/337; A61K31/352; A61K31/4375; A61K31/575; A61K31/704; A61K47/42; A61P35/00; C07K14/79
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda