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Title:
神経発生を増大させるための組成物および方法
Document Type and Number:
Japanese Patent JP2006514630
Kind Code:
A
Abstract:
The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca<2+> elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.

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Inventors:
Betilson, Goulan
Airlandson, Ricardo
Friesen, Jonas
The Hague Strand, Andaz
Heidrich, Jessica
Health Room, Christina
Hug Blood, Johann
Catalina janson
Corte Smar, Jerkow
Lindquist, Par
Land, Hana
Maguaia, Jacqueline
Mercer, Alex
Karl Nuberg
Osoinac, Amina
Patron, Cesare
Ronholm, Harriet
Sacherisson, Olof
Wixtreme, Lillian
Application Number:
JP2004553032A
Publication Date:
May 11, 2006
Filing Date:
November 20, 2003
Export Citation:
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Assignee:
Neuronova AB
Betilson, Goulan
Airlandson, Ricardo
Friesen, Jonas
The Hague Strand, Andaz
Heidrich, Jessica
Health Room, Christina
Hug Blood, Johann
Catalina janson
Corte Smar, Jerkow
Lindquist, Par
Land, Hana
Maguaia, Jacqueline
Mercer, Alex
Karl Nuberg
Osoinac, Amina
Patron, Cesare
Ronholm, Harriet
Sacherisson, Olof
Wixtreme, Lillian
International Classes:
A61K45/00; A61K31/352; A61K31/4015; A61K31/675; A61K31/7076; A61K35/74; A61K38/00; A61K38/16; A61K38/22; A61P9/10; A61P19/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P37/00; A61P43/00; C07D311/92; C12N15/09
Domestic Patent References:
JP2002518990A2002-07-02
JP2002530067A2002-09-17
Foreign References:
US6284539B12001-09-04
WO2002083877A12002-10-24
WO2002086106A12002-10-31
Other References:
RIAZ,S.S. ET AL: "The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon", BRAIN RES DEV BRAIN RES, vol. 136, no. 1, JPN6010001508, May 2002 (2002-05-01), pages 27 - 34, XP055739822, ISSN: 0001518434, DOI: 10.1016/S0165-3806(02)00310-3
MORRISON,S.J. ET AL: "Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated", J NEUROSCI, vol. 20, no. 19, JPN7010000082, 2000, pages 7370 - 6, XP002552625, ISSN: 0001518435
PERRY,T. ET AL: "A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated", J PHARMACOL EXP THER, vol. 300, no. 3, JPN7010002548, 2002, pages 958 - 66, XP002402955, ISSN: 0001702071, DOI: 10.1124/jpet.300.3.958
PERRY,T. ET AL: "Novel neuroprotective role of glucagon-like peptide-1 (GLP-1): Implications in neurodegenerative dis", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, JPN7010002549, 2001, pages 298, XP008072635, ISSN: 0001702072
PERRY,T. ET AL: "Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 302, no. 3, JPN7010002550, September 2002 (2002-09-01), pages 881 - 8, XP002402954, ISSN: 0001702073, DOI: 10.1124/jpet.102.037481
MONTROSE-RAFIZADEH,C. ET AL: "High potency antagonists of the pancreatic glucagon-like peptide-1 receptor", J BIOL CHEM, vol. 272, no. 34, JPN7010002551, 1997, pages 21201 - 6, XP002247450, ISSN: 0001702074, DOI: 10.1074/jbc.272.34.21201
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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