Title:
脈管系および中枢神経系に作用する三環系化合物および四環系化合物
Document Type and Number:
Japanese Patent JP2013507329
Kind Code:
A
Abstract:
This invention is related to chemistry and pharmacy and, in particular, to the production of novel molecular entities: tricyclic and tetracyclic derivatives of the benzodiazepine, pyridodiazepine, and pyrimidodiazepine type fused with 1,4-dihydropyridine derivatives, acting upon the Vascular and Central Nervous Systems. From derivatives containing a dihydropyridine ring reacting with compounds of the ortho -phenyldiamine, ortho -diaminopyridine, and ortho -diaminopyrimidine type, as well as some subsequent transformations thereof, tricyclic and tetracyclic derivatives of the I-XII general formula can be obtained, with a diazepine or diazepinone nucleus fused to a 1,4-dihydropyridine nucleus, wherein cycle A is a substituted or unsubstituted ring of benzene, pyridine or pyrimidine. Such molecular entities have a GABAergic and modulating action on calcium channels that can be used to treat cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric, and neurologic diseases.
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Inventors:
Verdesia Reyes, Yamira
Ochoa Rodriguez, Estael
Louis Reyes Albert
Nunes Figuered, Janiel
Carillo Dominguez, Carmen
Tacolente Morales, Huang Enrique
Alba Gutierrez, Rivan Lazarus
Pardo Andreu, Gilbert Lazarus
Ochoa Rodriguez, Estael
Louis Reyes Albert
Nunes Figuered, Janiel
Carillo Dominguez, Carmen
Tacolente Morales, Huang Enrique
Alba Gutierrez, Rivan Lazarus
Pardo Andreu, Gilbert Lazarus
Application Number:
JP2012532450A
Publication Date:
March 04, 2013
Filing Date:
October 08, 2010
Export Citation:
Assignee:
CENTRO DE INVESTIGACION Y DESARROLLO DE MEDICAMENTOS(CIDEM)
LABORATORIO DE SINTESIS ORGANICA DE LA FACULTAD DE QUIMICA DE LA UNIVERSIDAD DE LA HABANA
LABORATORIO DE SINTESIS ORGANICA DE LA FACULTAD DE QUIMICA DE LA UNIVERSIDAD DE LA HABANA
International Classes:
C07D471/04; A61K31/5513; A61P9/00; A61P25/00; A61P25/18; A61P25/28; C07D471/14; C07D491/147
Other References:
JPN6014030073; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８, 1991, ｐｐ．１３３９-１３４０
JPN6014030076; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１, 1994, ｐｐ．４９-５２
JPN6014030080; Ｆａｒｍａｃｏ， Ｅｄｉｚｉｏｎｅ Ｓｃｉｅｎｔｉｆｉｃａ Ｖｏｌ．４０， Ｎｏ．６, 1985, ｐｐ．３９１-４０３
JPN6014030073; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８, 1991, ｐｐ．１３３９-１３４０
JPN6014030076; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１, 1994, ｐｐ．４９-５２
JPN6014030080; Ｆａｒｍａｃｏ， Ｅｄｉｚｉｏｎｅ Ｓｃｉｅｎｔｉｆｉｃａ Ｖｏｌ．４０， Ｎｏ．６, 1985, ｐｐ．３９１-４０３
JPN6014030076; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１, 1994, ｐｐ．４９-５２
JPN6014030080; Ｆａｒｍａｃｏ， Ｅｄｉｚｉｏｎｅ Ｓｃｉｅｎｔｉｆｉｃａ Ｖｏｌ．４０， Ｎｏ．６, 1985, ｐｐ．３９１-４０３
JPN6014030073; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８, 1991, ｐｐ．１３３９-１３４０
JPN6014030076; Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１, 1994, ｐｐ．４９-５２
JPN6014030080; Ｆａｒｍａｃｏ， Ｅｄｉｚｉｏｎｅ Ｓｃｉｅｎｔｉｆｉｃａ Ｖｏｌ．４０， Ｎｏ．６, 1985, ｐｐ．３９１-４０３
Attorney, Agent or Firm:
Hitoshi Shinbo