Title:
スピロ-オキシインドールMDM2アンタゴニスト
Document Type and Number:
Japanese Patent JP2014513699
Kind Code:
A
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
More Like This:
Inventors:
Wang, Xiamen
Sun, Way
Angelo, Aguilar
Garcia-Echeveria, Carlos
Sun, Way
Angelo, Aguilar
Garcia-Echeveria, Carlos
Application Number:
JP2014510503A
Publication Date:
June 05, 2014
Filing Date:
May 11, 2012
Export Citation:
Assignee:
The Regents of the University of Michigan
International Classes:
C07D487/10; A61K31/407; A61K31/41; A61K31/438; A61K31/4439; A61K31/4545; A61K31/5377; A61P35/00; A61P35/02; A61P43/00; C07D487/20; C07D491/20
Domestic Patent References:
| JP2008531504A | 2008-08-14 | |||
| JP2010502620A | 2010-01-28 |
Foreign References:
| WO2012121361A1 | 2012-09-13 |
Other References:
LIU, JIE ET AL.: "Direct construction of novel exo'-selective spiropyrrolidine bisoxindoles via a three-component 1,3-", TETRAHEDRON LETTERS, vol. 53(18), JPN6014052498, 2012, pages 2336 - 2340, ISSN: 0002963132
DING, KE ET AL.: "Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2-", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49(12), JPN6014052501, 2006, pages 3432 - 3435, ISSN: 0002963133
DING, KE ET AL.: "Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2-", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49(12), JPN6014052501, 2006, pages 3432 - 3435, ISSN: 0002963133
Attorney, Agent or Firm:
Harakenzo world patent & trademark