Title:
腫瘍または細胞特異的な単純ヘルペスウイルスの複製
Document Type and Number:
Japanese Patent JP3865319
Kind Code:
B2
Abstract:
A method for killing tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with an essential herpes simplex virus gene which is driven by a tumor-specific or cell-specific promoter that specifically destroys tumor cells and is not neurovirulent. Also, a method for producing an animal model, by ablating a specific cell type in vivo, entails providing replication competent herpes simplex virus vectors to the animal. Such a vector, with an essential herpes simplex virus gene driven by a cell- or tissue-specific promoter, specifically destroys the target cell type. This method of viral-mediated gene therapy employs cell-specific viral replication, where viral replication and associated cytotoxicity are limited to a specific cell-type by the regulated expression of an essential immediate-early (IE) viral gene product.
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Inventors:
Martsga Robert El.
Lovekin Samuel Dee.
Miyatake Shinichi
Lovekin Samuel Dee.
Miyatake Shinichi
Application Number:
JP50115797A
Publication Date:
January 10, 2007
Filing Date:
June 06, 1996
Export Citation:
Assignee:
GEORGETOWN UNIVERSITY
International Classes:
C12N15/09; A01K67/027; A61K39/00; A61K39/12; A61K39/245; A61K48/00; A61P35/00; C07H21/04; C07K14/035; C12N5/10; C12N7/00; C12N7/01; C12N15/85; C12N15/869; A61K38/00; C12R1/92
Domestic Patent References:
| JP10506289A |
Foreign References:
| WO1992007945A1 |
Other References:
Gene Ther. Meet Cold Spring Harbor,(1994),p155
Attorney, Agent or Firm:
Hatsushi Shimizu