Title:
HDAC阻害剤の医薬製剤
Document Type and Number:
Japanese Patent JP5108750
Kind Code:
B2
Abstract:
This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine, and meglumine. The present invention also pertains to the use of such compositions, for example, in the inhibition of HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
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Inventors:
Bustin, Richard, Jay.
Hughes, Nicholas, Jay.
Hughes, Nicholas, Jay.
Application Number:
JP2008510642A
Publication Date:
December 26, 2012
Filing Date:
May 11, 2006
Export Citation:
Assignee:
Topo Target UK Limited
International Classes:
A61K31/18; A61K9/08; A61K9/14; A61K9/16; A61K9/19; A61K9/20; A61K47/18; A61P1/04; A61P1/16; A61P3/10; A61P7/06; A61P9/10; A61P11/02; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P33/02; A61P33/06; A61P33/10; A61P35/00; A61P37/00; A61P37/08
Domestic Patent References:
| JP2004511462A | ||||
| JP2003321364A | ||||
| JP2000212088A | ||||
| JP5505813A |
Foreign References:
| WO2005040106A1 | ||||
| WO1997030706A1 |
Other References:
Mura P, et al.,Ternary systems of naproxen with hydroxypropyl-β-cyclodextrin and aminoacids,International Journal of Pharmaceutics,2003年 7月24日,Vol. 260, No. 2,p. 293-302
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai
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