エバーメクチン誘導体

Japanese Patent JP5439464

B2

A compound represented by the general formula (I) or a salt thereof: wherein represents -CH-CH-, -CH₂-CH₂- or the like, between R¹ and the carbon atom at 4'-position represents a single bond or a double bond, between R² and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when represents -CH-CH- or -CH₂-CH₂-, and between R¹ and the carbon atom at 4'-position represents a double bond, R¹ represents -C(R¹¹)(R¹²) (wherein R¹¹ represents a lower alkyl group or the like and R¹² represents a hydrogen atom or the like) or the like, and R² represents a hydroxyl group or the like, or R² may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when represents -CH-CH- or -CH₂-CH₂-, and between R¹ and the carbon atom at 4'-position represents a single bond, R¹ represents -OCH(R^1a)(R^1b) (wherein R^1a represents a lower alkyl or the like and R^1b represents a hydrogen atom or the like) or the like, and R² represents a hydroxyl group or the like.

WO/2015/100420	CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF
JPH07106155	[Title of the Invention] Method for producing an antibiotic compound
JPH05115289	NEW COMPOUND RGT-2, ITS PRODUCTION AND ANTITUMOR AGENT COMPRISING THE SAME COMPOUND AS ACTIVE INGREDIENT

Satoshi Omura
Kenichiro Nagai
Toshiaki Sunatsuka

JP2011265938A

March 12, 2014

December 05, 2011

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Kitasato Institute

C07D493/22; A61K31/35; A61K31/365; A61K31/4433; A61K31/453; A61K31/496; A61K31/5377; A61P33/00; A61P33/10; C07H17/08

JP2078683A
JP5202057A
JP55024165A
JP7505363A
JP8506352A
JP9501950A

US5362863

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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