Title:
磁性粒子含有水分散体の製造方法
Document Type and Number:
Japanese Patent JP5765520
Kind Code:
B2
Abstract:
The present invention relates to a magnetic particle-containing water dispersion wherein the magnetic particles have a primary particle diameter of 5 to 15 nm and an average secondary particle diameter of 10 to 60 nm, and the water dispersion has a zeta potential of not more than -20 mV when a pH value of the water dispersion lies within the range of 6 to 8, and further a surface of the respective magnetic particles is coated with a carboxyl group-containing polymer. The magnetic particle-containing water dispersion is produced by heating an aqueous solution in which the carboxyl group-containing polymer is dissolved, to a temperature of 90 to 100°C in a nitrogen atmosphere; adding a solution of a ferrous (II) salt and a ferric (III) salt and an alkali solution to the aqueous solution to react with each other at the same temperature; adding ethanol to the solution to obtain a precipitate; and removing a supernatant liquid from the solution, and then dispersing the precipitate in water and subjecting the resulting dispersion to dialysis. The magnetic particle-containing water dispersion is useful as a magnetic particle-containing water dispersion capable of producing magnetic particle-containing drugs for diagnosis and therapies which can exhibit a uniform functionality, with a good reproducibility.
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Inventors:
Toshiyuki Hakata
Tomoko Okita
Tomoko Okita
Application Number:
JP2010259432A
Publication Date:
August 19, 2015
Filing Date:
November 19, 2010
Export Citation:
Assignee:
Toda Kogyo Co., Ltd.
International Classes:
A61K47/30; A61K47/32; A61K49/00
Domestic Patent References:
| JP2006028032A |
Foreign References:
| WO1995031220A1 |
Other References:
Journal of Colloid and Interfaces Sciencce,2005年,Vol.291,p.411-420