20-O-ACYL-19,20-ENOL MACROLIDE ANTIBIOTIC SUBSTANCE DERIVATIVE

Title:

20-O-ACYL-19,20-ENOL MACROLIDE ANTIBIOTIC SUBSTANCE DERIVATIVE

Document Type and Number:

Japanese Patent JPS62242694

Kind Code:

A

Abstract:

NEW MATERIAL:A compound of formula I [R is lower alkanoyl or cycloalkyl- lower alkanoyl; R1 is 2W3C alkanoyl; R1 is H, methyl, -COOR4 (R4 is lower alkyl, aryl, aralkyl, etc.), -CONHR5 (R5 is lower alkyl, aryl or aralkyl), -CH2X (X is halogen), etc.; R3 is H or OH; A is single bond or O] or its salt.

EXAMPLE: 3,20-Di-O-propionyl-19,20-enol-23-O-dimethylcarbamoyl-O-mycaminosyl- tylonolide.

USE: An antibacterial agent capable of keeping high concentration in blood by oral administration.

PREPARATION: The objective compound can be produced e.g. by reacting a 19-formyl-macrolide antibiotic substance of formula II with a carboxylic acid anhydride of formula ROR in the presence of a base.

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Inventors:

FUJIWARA TATSURO
WATANABE HIDEYUKI
SAKAKIBARA HIDEO

Application Number:

JP8679186A

Publication Date:

October 23, 1987

Filing Date:

April 15, 1986

Export Citation:

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Assignee:

TOYO JOZO KK

International Classes:

A61K31/70; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): A61K31/70; C07H17/08

Attorney, Agent or Firm:

Miyuki Ariga (2 outside)

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