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Title:
3-N SUBSTITUTED CARBAMOYL-INDOLE DERIVATIVE
Document Type and Number:
Japanese Patent JPH02292281
Kind Code:
A
Abstract:

NEW MATERIAL: A compd. represented by formula I or II [wherein R0 is a 1-4C alkyl, an alkoxy, OH or a halogen, R2 and R3 are each H, a 1-4C alkyl, a 3-6C alkenyl, a cycloalkyl or benzyl, R1 is H, a 1-8C alkyl, a 3-7C cycloalkyl or phenyl, Z forms a 5-8-membered heterocycle along with C, N and intermeidate C and, at this time, secondary heteroatoms of N, O and S may be present and A is groups represented by formulae III, IV (one of R11-R13 is H or a 1-6C alkyl and the other two of them are each H or a 1-4C alkyl)].

EXAMPLE: N-Methyl, N-[(5-methyl-1H-imidazol-4-yl)methyl]-4-methyl-5,6-dihydro-4 H-pyrrolo[3,2,1-ij]quinoline-1-carboxamide.HCl.

USE: An antagonist against 5-hydroxytriptamine.

PROCESS: Compds. represented by formulae V, VI and a compd. represented by formula VII are reacted.


Inventors:
INEKE FUAN UIENGAARUDEN
DERUKU HAMINGA
HANSU HAINTSU HAEKU
UOOTERU UOOTERUSU
Application Number:
JP9950490A
Publication Date:
December 03, 1990
Filing Date:
April 17, 1990
Export Citation:
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Assignee:
DUPHAR INT RES
International Classes:
A61K31/415; A61P43/00; C07D223/16; C07D225/06; C07D403/12; C07D471/06; C07D487/04; C07D215/58; C07D487/06; C07D513/06; (IPC1-7): A61K31/415; C07D215/58; C07D223/16; C07D225/06; C07D403/12; C07D487/04; C07D513/06
Attorney, Agent or Firm:
Akihide Sugimura (5 outside)