Title:
がんおよび糖尿病の治療に有用な６−ヘテロシクリル−４−モルホリン−４−イルピリジン−２−オン化合物
Document Type and Number:
Japanese Patent JP6858984
Kind Code:
B2
Abstract:
The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections;wherein R1, R2, R3 and A are as defined in the specification.
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Inventors:
Jessica Martinson
Martin Andesion
Ioan Lindstrom
Ricardo force bloom
Fred Rick Ram
Tobias Ginman
Yanne Biklund
Martin Andesion
Ioan Lindstrom
Ricardo force bloom
Fred Rick Ram
Tobias Ginman
Yanne Biklund
Application Number:
JP2018562702A
Publication Date:
April 14, 2021
Filing Date:
February 17, 2017
Export Citation:
Assignee:
Sprint Bioscience Actie Borrag
International Classes:
A61K31/5377; C07D413/14; A61K31/5386; A61K31/541; A61K38/21; A61K45/00; A61P1/18; A61P3/10; A61P9/00; A61P11/00; A61P15/14; A61P17/00; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P43/00; C07D401/04; C07D413/04; C07D417/14
Domestic Patent References:
| JP2015525236A |
Foreign References:
| US20140275003 | ||||
| WO2015030057A1 |
Other References:
Roedig, Alfred; Grohe, Klaus; Sommer, Herbert,Nucleophilic substitutions of (Z)-perchloro-1,3-butadiene-1-carbonitrile with sodium phenolate and secondary aliphatic amines,Chemische Berichte ,1982年,115(5),1733-8
Coffman, Karen; Brodney, Michael; Cook, James; Lanyon, Lorraine; Pandit, Jayvardhan; Sakya, Subas; Schachter, Joel; Tseng-Lovering, Elaine; Wessel, Matthew,6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors,Bioorganic & Medicinal Chemistry Letters ,2011年,21(5),1429-1433
Coffman, Karen; Brodney, Michael; Cook, James; Lanyon, Lorraine; Pandit, Jayvardhan; Sakya, Subas; Schachter, Joel; Tseng-Lovering, Elaine; Wessel, Matthew,6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors,Bioorganic & Medicinal Chemistry Letters ,2011年,21(5),1429-1433
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Sachiko Okabe
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Sachiko Okabe