Title:
陽イオン性脂質を含む陰イオン性薬物伝達体およびその製造方法
Document Type and Number:
Japanese Patent JP5836394
Kind Code:
B2
Abstract:
Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase thein vivostability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.
More Like This:
Inventors:
Choi, Songwon
La Munho
Son, Jiyoung
Seo, Minhyo
La Munho
Son, Jiyoung
Seo, Minhyo
Application Number:
JP2013547365A
Publication Date:
December 24, 2015
Filing Date:
December 30, 2011
Export Citation:
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
International Classes:
A61K47/18; A61K9/10; A61K9/107; A61K9/127; A61K31/7088; A61K31/7105; A61K47/34; A61K47/48; A61K48/00
Domestic Patent References:
| JP2007056427A | ||||
| JP61500729A | ||||
| JP8183979A |
Foreign References:
| US4551505 | ||||
| WO2008042973A1 | ||||
| US5744335 |
Attorney, Agent or Firm:
Ryu Iwatani