Title:
ANNEXIN 1 ANTIBODY
Document Type and Number:
Japanese Patent JP2017061459
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a specific binding molecule having an increased affinity to the human Anx-A1 protein having a specific amino acid sequence.SOLUTION: The present invention provides a monoclonal antibody against the human Anx-A1 protein and a hybridoma cell line deposited with ECACC as Accession No. 10060301, which is of cells that produce the antibody. The antibody is therapeutically effective to a T cell-mediated disease selected from transplant vs host disease, transplant rejection, atherosclerosis, HIV, AIDS, psoriasis, abortion, and autoimmune diseases.SELECTED DRAWING: None
More Like This:
Inventors:
FULVIO D'ACQUISTO
PERRETTI MAURO
PERRETTI MAURO
Application Number:
JP2016197324A
Publication Date:
March 30, 2017
Filing Date:
October 05, 2016
Export Citation:
Assignee:
UNIV LONDON QUEEN MARY
International Classes:
C07K16/18; A61K39/395; A61P1/04; A61P3/10; A61P17/00; A61P19/02; A61P21/00; A61P27/02; A61P29/00; A61P37/02; A61P43/00; C12N5/16; C12N15/02; C12P21/08
Domestic Patent References:
| JP2013534914A | 2013-09-09 |
Foreign References:
| WO2010064012A2 | 2010-06-10 |
Other References:
TANG, D. ET AL., NATURE, vol. 356, JPN6015025123, 1992, pages 152 - 154, ISSN: 0003629979
D'ACQUISTO, F. ET AL., BR. J. PHARMACOL., vol. 155, JPN6015025128, 2008, pages 152 - 169, ISSN: 0003629980
BLOOD, vol. 109, no. 3, JPN6013054352, 2007, pages 1095 - 1102, ISSN: 0003629981
YANG, Y. ET AL., ARTHRITIS RHEUMATISM, vol. 42, JPN6015025129, 1999, pages 1538 - 1544, ISSN: 0003629982
FEBS LETTERS, vol. 261, no. 2, JPN6013054347, 1990, pages 247 - 252, ISSN: 0003629983
免疫学辞典, vol. 第2版, JPN6017032431, 2001, pages 384, ISSN: 0003629984
EUR.J.IMMUNOL., vol. 37, JPN6013054350, 2007, pages 3131 - 3142, ISSN: 0003629985
CROXTALL, J.D. ET AL., BIOCHEM. PHARMACOL., vol. 52, JPN6017032433, 1996, pages 351 - 356, ISSN: 0003629986
CROXTALL, J.D. ET AL., BIOCHEM. PHARMACOL., vol. 50, no. 4, JPN6017032434, 1995, pages 465 - 474, ISSN: 0003629987
石田博, 日本内科学会雑誌, vol. 87, JPN6017032436, 1998, pages 1595 - 1600, ISSN: 0003629988
SUN, J. ET AL., CELL. MOL. IMMUNOL., vol. 8, JPN6017032438, 2011, pages 348 - 358, ISSN: 0003629989
BOYLE, J.S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, JPN6015025124, 1997, pages 14626 - 14631, ISSN: 0003629990
TIGHE, H. ET AL., IMMUNOL. TODAY, vol. 19, no. 2, JPN6015025125, 1998, pages 89 - 97, ISSN: 0003629991
D'ACQUISTO, F. ET AL., BR. J. PHARMACOL., vol. 155, JPN6015025128, 2008, pages 152 - 169, ISSN: 0003629980
BLOOD, vol. 109, no. 3, JPN6013054352, 2007, pages 1095 - 1102, ISSN: 0003629981
YANG, Y. ET AL., ARTHRITIS RHEUMATISM, vol. 42, JPN6015025129, 1999, pages 1538 - 1544, ISSN: 0003629982
FEBS LETTERS, vol. 261, no. 2, JPN6013054347, 1990, pages 247 - 252, ISSN: 0003629983
免疫学辞典, vol. 第2版, JPN6017032431, 2001, pages 384, ISSN: 0003629984
EUR.J.IMMUNOL., vol. 37, JPN6013054350, 2007, pages 3131 - 3142, ISSN: 0003629985
CROXTALL, J.D. ET AL., BIOCHEM. PHARMACOL., vol. 52, JPN6017032433, 1996, pages 351 - 356, ISSN: 0003629986
CROXTALL, J.D. ET AL., BIOCHEM. PHARMACOL., vol. 50, no. 4, JPN6017032434, 1995, pages 465 - 474, ISSN: 0003629987
石田博, 日本内科学会雑誌, vol. 87, JPN6017032436, 1998, pages 1595 - 1600, ISSN: 0003629988
SUN, J. ET AL., CELL. MOL. IMMUNOL., vol. 8, JPN6017032438, 2011, pages 348 - 358, ISSN: 0003629989
BOYLE, J.S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, JPN6015025124, 1997, pages 14626 - 14631, ISSN: 0003629990
TIGHE, H. ET AL., IMMUNOL. TODAY, vol. 19, no. 2, JPN6015025125, 1998, pages 89 - 97, ISSN: 0003629991
Attorney, Agent or Firm:
Hisashi Tsuji
Previous Patent: Organic compound
Next Patent: Use of isothiazole Carboxamide for bringing about a host's potential defense in a plant
Next Patent: Use of isothiazole Carboxamide for bringing about a host's potential defense in a plant