Title:
ANTI-GITR ANTIBODIES AND USE METHODS THEREOF
Document Type and Number:
Japanese Patent JP2023021446
Kind Code:
A
Abstract:
To provide anti-GITR antibodies and methods of use thereof.SOLUTION: The disclosure provides an antibody that specifically binds to a human glucocorticoid-induced TNFR family related receptor (GITR) and a composition comprising such an antibody. In a specific aspect, an antibody that specifically binds to human GITR is used to modulate GITR activity, for example, activating GITR, or enhancing or inducing its activity. The disclosure also provides a method for treating disorders such as cancer and infections by administering an antibody that specifically binds to human GITR to modulate GITR activity, for example, activating GITR, or enhancing or inducing its activity.SELECTED DRAWING: None
Inventors:
Dennis Jay. Underwood
Olivier Leger
Volker Sievert
Marc van Dijk
David Skael
Takemasa Tsuji
Gelt Ritter
Anna M. Gonzales
Nicholas S. Wilson
Roberta Zappasody
Taha Melgoub
Jed David Wolchok
Olivier Leger
Volker Sievert
Marc van Dijk
David Skael
Takemasa Tsuji
Gelt Ritter
Anna M. Gonzales
Nicholas S. Wilson
Roberta Zappasody
Taha Melgoub
Jed David Wolchok
Application Number:
JP2022202168A
Publication Date:
February 10, 2023
Filing Date:
December 19, 2022
Export Citation:
Assignee:
Agenus Incorporated
Memorial Sloan Kettering Cancer Center
Ludwig Institute for Cancer Research RTD
Memorial Sloan Kettering Cancer Center
Ludwig Institute for Cancer Research RTD
International Classes:
C07K16/28; A61K31/405; A61K31/4188; A61K31/4245; A61K31/47; A61K35/17; A61K39/395; A61K45/00; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P37/02; A61P37/04; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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