To obtain a new compound having a significant activity in an action potential duration time extension method exhibiting an antiarrhythmic activity and useful as a medicine for treating cardiac arrhythmia in mammalian.
A compound of formula I {R1 is imidazol-1-yl, pyrazol-3-yl, pyrimidin-4-yl, etc.; X is O, S, SO, SO2; D is a group of the formula: (CH2)n ((n) is 3-10), a group of the formula: (CH2)k-CH=CH-(CH2)m[(k), (m) are each 1-4; the double bond exhibits a cis-isomer or a trans-isomer), etc.; Y is a group of the formula: COR2 {R2 is phenyl[substituted by one to three of a 1-4C (branched) alkyl, CF3, a halogen, etc.]], thiophen-2-yl, etc.}, a group of the formula: SO2R2}, its salt. For example, 4-t-butyl-N-{4-[4-(imidazol-1-yl) phenoxy]butyl}benzenesulfonamide. The compound of formula I is obtained by reacting a compound of formula II with a compound of the formula: YCl.
JIYOZEFU UIRIAMU HINSON
