Title:
BISISOXAZOLINE DERIVATIVE, PRODUCTION THEREFOR AND METALLIC COMPLEX CATALYST THEREFROM
Document Type and Number:
Japanese Patent JP3896774
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide an asymmetric synthesis catalyst having higher activity in order to obtain optically active compounds useful as a synthetic intermediate for medicines, agrochemicals and the like.
SOLUTION: The objective compound is a bisisoxazoline derivative represented by general formula [I] (R is H, an alkyl, an alkenyl, an aralkyl which may be substituted, or an aryl which may be substituted; the four Rs may be all identical or at least one may differ from the others; R' is a single bond or an alkylene). In a preferred embodiment, all of the Rs are Hs or methyls and R' is methylene. In addition, an optically active bisisoxazoline derivative of formula [I] is provided as an asymmetric synthesis catalyst and the asymmetric synthesis catalyst is the complex of the optically active bisisoxazoline derivative of formula [I] including a transition metal as a ligand.
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| JPH11116564 | CHROMONE DERIVATIVE |
Inventors:
Arai green
Takayoshi Arai
Hiroaki Sasai
Takayoshi Arai
Hiroaki Sasai
Application Number:
JP2000236406A
Publication Date:
March 22, 2007
Filing Date:
August 04, 2000
Export Citation:
Assignee:
Daiso Co., Ltd.
International Classes:
C07D309/24; C07D498/10; C07B53/00; C07B61/00; C07C29/159; C07C29/36; C07C33/02; C07C33/28; C07C35/21; C07C45/29; C07C45/69; C07C47/21; C07C47/238; C07C49/403; C07C249/08; C07C251/40; C07D493/08; (IPC1-7): C07D498/10; C07B53/00; C07C29/159; C07C29/36; C07C33/02; C07C33/28; C07C35/21; C07C45/29; C07C45/69; C07C47/21; C07C47/238; C07C49/403; C07C249/08; C07C251/40; C07D309/24; //C07B61/00; C07D493/08
Domestic Patent References:
| JP10287663A |
Other References:
Urs LEUTENEGGER et al.,"5-Aza-Semicorrins: A New Class of Bidentate Nitrogen Ligands for Enantioselective Catalysis",Tetrahedron,1992年 3月13日,vol.48, no.11,p.2143-2156
David A. EVANS et al.,"Bis(oxazolines) as Chiral Ligands in Metal-Catalyzed Asymmetric Reactions. Catalytic, Asymmetric Cyclopropanation of Olefins",J. Am. Chem. Soc.,1991年 1月16日,vol.113, no.2,p.726-728
E. J. COREY et al.,"Designed Catalyst for Enantioselective Diels-Alder Addition from a C2-Symmetric Chiral Bis(oxazoline)-Fe(III) Complex",J. Am. Chem. Soc.,1991年 1月16日,vol.113, no.2,p.728-729
TIETZE, Lutz F. et al.,"Palladium-catalyzed allylic substitution on solid support",Chemical Communications,1998年 4月 7日,no.7,p.793-794
SAMU, Erika et al.,"Enantiomerically pure chiral phenazino-crown ethers: synthesis, preliminary circular dichroism spectroscopic studies and complexes with the enantiomers of 1-arethyl ammonium salts",Tetrahedron: Asymmetry,1999年 7月16日,vol.10, no.14,p.2775-2795
NUGENT, William A. et al.,"Zirconium-mediated ring construction from dienes: remarkable effect of ligands on stereochemistry",Journal of the American Chemical Society,1989年 8月 2日,vol.111, no.16,p.6435-6437
David A. EVANS et al.,"Bis(oxazolines) as Chiral Ligands in Metal-Catalyzed Asymmetric Reactions. Catalytic, Asymmetric Cyclopropanation of Olefins",J. Am. Chem. Soc.,1991年 1月16日,vol.113, no.2,p.726-728
E. J. COREY et al.,"Designed Catalyst for Enantioselective Diels-Alder Addition from a C2-Symmetric Chiral Bis(oxazoline)-Fe(III) Complex",J. Am. Chem. Soc.,1991年 1月16日,vol.113, no.2,p.728-729
TIETZE, Lutz F. et al.,"Palladium-catalyzed allylic substitution on solid support",Chemical Communications,1998年 4月 7日,no.7,p.793-794
SAMU, Erika et al.,"Enantiomerically pure chiral phenazino-crown ethers: synthesis, preliminary circular dichroism spectroscopic studies and complexes with the enantiomers of 1-arethyl ammonium salts",Tetrahedron: Asymmetry,1999年 7月16日,vol.10, no.14,p.2775-2795
NUGENT, William A. et al.,"Zirconium-mediated ring construction from dienes: remarkable effect of ligands on stereochemistry",Journal of the American Chemical Society,1989年 8月 2日,vol.111, no.16,p.6435-6437
Attorney, Agent or Firm:
Einosuke Kishimoto
Moriichi Kishimoto
Akira Watanabe
Norihiko Hibi
Kiyosue Yasuko
Moriichi Kishimoto
Akira Watanabe
Norihiko Hibi
Kiyosue Yasuko