カスパーゼのインヒビター - VERTEX PHARMACEUTICALS INCORPORATED

Title:

カスパーゼのインヒビター

Document Type and Number:

Japanese Patent JP4594520

Kind Code:

B2

Abstract:

The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1² converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1- ("IL-1"), apoptosis-, interferon-³ inducing factor-(IGIF), or interferon-³-("IFN-³") mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-³ production and methods for treating interieukin-1, apoptosis-, and interferon-³ mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.

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Inventors:

Wannamaker, Marion W.
Bemis, Guy W.
Charifson, Paul S.
Raffer, David Jay.
Murican, Michael Dee.
Murco, Mark A.
Wilson, Keith Pee.
Janetka, James W.
Davis, Robert Jay.
Grilot, Anne-Laura
Shi, Zan
Forster, Cornelia Jay.

Application Number:

JP2000536738A

Publication Date:

December 08, 2010

Filing Date:

March 19, 1999

Export Citation:

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Assignee:

VERTEX PHARMACEUTICALS INCORPORATED

International Classes:

C07D207/273; A61K31/47; C07K5/083; A61K38/00; A61K38/03; A61K38/04; A61P5/48; A61P7/00; A61P9/00; A61P17/00; A61P19/00; A61P19/08; A61P19/10; A61P25/00; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07D401/12; C07K5/02; C07K5/023

Domestic Patent References:

JP5255218A
JP7089951A
JP2006206600A
JP2001501923A
JP9165360A
JP6340691A

Foreign References:

WO1995035308A1
WO1997022619A1
GB2292149A

Other References:

Bioorg.Med.Chem.Lett.,Vol.8,No.19(1998.Oct.)p.2757-2762
Int.J.Pept.Protein Res.,Vol.44,No.2(1994)p.173-182
Bioorg.Med.Chem.Lett.,Vol.4,No.19(1994)p.2359-2364

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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